Single cell type - TCERG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TCERG1
Gene descriptionⁱ Full gene name according to HGNC.	Transcription elongation regulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TCERG1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.99
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RBM25	RNA binding motif protein 25	0.6090	52
CCAR1	Cell division cycle and apoptosis regulator 1	0.6045	10
CDK12	Cyclin dependent kinase 12	0.5942	10
HNRNPA3	Heterogeneous nuclear ribonucleoprotein A3	0.5924	10
PRPF40A	Pre-mRNA processing factor 40 homolog A	0.5894	10
SMC1A	Structural maintenance of chromosomes 1A	0.5811	10
ZNF207	Zinc finger protein 207	0.5805	52
SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein	0.5803	10
NOP14	NOP14 nucleolar protein	0.5702	10
SREK1	Splicing regulatory glutamic acid and lysine rich protein 1	0.5602	52
HNRNPR	Heterogeneous nuclear ribonucleoprotein R	0.5576	10
UBE3A	Ubiquitin protein ligase E3A	0.5557	10
HNRNPA2B1	Heterogeneous nuclear ribonucleoprotein A2/B1	0.5447	10
PARP2	Poly(ADP-ribose) polymerase 2	0.5374	10
C5orf34	Chromosome 5 open reading frame 34	0.5366	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	35.8 nTPM
Adipose tissue	43.6 nTPM
Breast	27.9 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Alveolar cells type 2	49.8 nTPM
Lung	49.8 nTPM

Astrocytes	50.6 nTPM
Brain	50.6 nTPM

B-cells	49.5 nTPM
Lymph node	68.7 nTPM
Spleen	64.4 nTPM
Stomach	63.6 nTPM
Adipose tissue	63.2 nTPM
Bone marrow	56.4 nTPM
Liver	44.6 nTPM
PBMC	37.1 nTPM
Colon	36.7 nTPM
Breast	32.1 nTPM
Kidney	28.5 nTPM

Dendritic cells	42.9 nTPM
Adipose tissue	55.8 nTPM
PBMC	43.8 nTPM
Breast	29.2 nTPM

Endothelial cells	37.6 nTPM
Endometrium	57.6 nTPM
Lung	56.1 nTPM
Prostate	48.4 nTPM
Esophagus	42.3 nTPM
Ovary	41.4 nTPM
Skeletal muscle	40.5 nTPM
Heart muscle	36.8 nTPM
Placenta	36.4 nTPM
Breast	31.5 nTPM
Pancreas	30.9 nTPM
Skin	29.6 nTPM
Testis	26.6 nTPM
Eye	25.9 nTPM
Liver	22.0 nTPM

Fibroblasts	43.3 nTPM
Lung	92.8 nTPM
Ovary	47.7 nTPM
Prostate	47.5 nTPM
Heart muscle	43.1 nTPM
Skeletal muscle	40.2 nTPM
Placenta	40.0 nTPM
Adipose tissue	38.4 nTPM
Esophagus	34.1 nTPM
Stomach	32.7 nTPM
Skin	30.0 nTPM
Breast	29.9 nTPM

Intestinal goblet cells	36.9 nTPM
Colon	39.3 nTPM
Small intestine	35.9 nTPM
Rectum	35.5 nTPM

Macrophages	36.5 nTPM
Lung	63.1 nTPM
Adipose tissue	60.8 nTPM
Endometrium	53.3 nTPM
Esophagus	50.4 nTPM
Stomach	43.9 nTPM
Skeletal muscle	42.3 nTPM
Bone marrow	36.3 nTPM
Spleen	36.3 nTPM
Kidney	31.8 nTPM
Breast	31.4 nTPM
Ovary	27.9 nTPM
Prostate	27.5 nTPM
Testis	27.4 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	25.3 nTPM
Rectum	36.3 nTPM
Small intestine	26.3 nTPM
Colon	13.2 nTPM

Plasma cells	61.9 nTPM
Spleen	86.5 nTPM
Bone marrow	79.1 nTPM
Esophagus	55.5 nTPM
Adipose tissue	47.1 nTPM
Stomach	41.4 nTPM

Respiratory ciliated cells	33.8 nTPM
Lung	43.7 nTPM
Bronchus	23.8 nTPM

Smooth muscle cells	51.1 nTPM
Bronchus	142.7 nTPM
Endometrium	56.2 nTPM
Heart muscle	56.0 nTPM
Skeletal muscle	48.8 nTPM
Prostate	48.7 nTPM
Esophagus	43.4 nTPM
Ovary	40.9 nTPM
Adipose tissue	38.0 nTPM
Pancreas	31.8 nTPM
Skin	29.6 nTPM
Breast	26.0 nTPM

T-cells	42.8 nTPM
Lung	83.6 nTPM
Lymph node	71.7 nTPM
Bone marrow	59.8 nTPM
Adipose tissue	58.2 nTPM
Stomach	56.5 nTPM
Spleen	51.5 nTPM
Endometrium	49.1 nTPM
Skeletal muscle	45.3 nTPM
Colon	40.4 nTPM
PBMC	39.7 nTPM
Esophagus	32.8 nTPM
Breast	32.6 nTPM
Liver	26.1 nTPM
Skin	24.4 nTPM
Ovary	22.3 nTPM
Kidney	19.1 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	44.9 nTPM
Skin	44.9 nTPM

Basal respiratory cells	35.6 nTPM
Bronchus	35.6 nTPM

Basal squamous epithelial cells	54.7 nTPM
Esophagus	54.7 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Undifferentiated cells	47.5 nTPM
Colon	52.0 nTPM
Rectum	45.8 nTPM
Small intestine	44.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC