Single cell type - ELMOD3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELMOD3
Gene descriptionⁱ Full gene name according to HGNC.	ELMO domain containing 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ELMOD3 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NHLRC3	NHL repeat containing 3	0.7508	52
ZNF224	Zinc finger protein 224	0.7131	52
TTC14	Tetratricopeptide repeat domain 14	0.6818	52
ZNF169	Zinc finger protein 169	0.6780	52
ZFP14	ZFP14 zinc finger protein	0.6491	52
POLR2J2	RNA polymerase II subunit J2	0.6391	52
ATF6B	Activating transcription factor 6 beta	0.6158	40
ZNF500	Zinc finger protein 500	0.6111	52
C19orf25	Chromosome 19 open reading frame 25	0.6021	52
CARF	Calcium responsive transcription factor	0.5964	52
N4BP2L2	NEDD4 binding protein 2 like 2	0.5873	52
POLM	DNA polymerase mu	0.5835	52
TRMT13	TRNA methyltransferase 13 homolog	0.5741	52
SLC25A45	Solute carrier family 25 member 45	0.5672	63
DDX17	DEAD-box helicase 17	0.5670	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.0 nTPM
Breast	10.7 nTPM
Adipose tissue	7.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	8.4 nTPM
Lung	8.4 nTPM

Astrocytes	36.9 nTPM
Brain	36.9 nTPM

B-cells	15.7 nTPM
PBMC	34.3 nTPM
Colon	22.3 nTPM
Bone marrow	19.6 nTPM
Liver	19.1 nTPM
Kidney	14.3 nTPM
Breast	13.4 nTPM
Stomach	11.8 nTPM
Spleen	10.0 nTPM
Adipose tissue	6.6 nTPM
Lymph node	5.9 nTPM

Dendritic cells	9.8 nTPM
Breast	11.7 nTPM
Adipose tissue	9.6 nTPM
PBMC	8.0 nTPM

Endothelial cells	9.5 nTPM
Testis	21.4 nTPM
Ovary	14.2 nTPM
Liver	12.8 nTPM
Pancreas	11.6 nTPM
Placenta	11.3 nTPM
Skeletal muscle	9.5 nTPM
Prostate	8.3 nTPM
Breast	8.3 nTPM
Esophagus	8.2 nTPM
Eye	7.3 nTPM
Heart muscle	7.2 nTPM
Skin	6.6 nTPM
Endometrium	5.6 nTPM
Lung	0.0 nTPM

Fibroblasts	10.0 nTPM
Placenta	16.2 nTPM
Ovary	14.5 nTPM
Stomach	11.9 nTPM
Skeletal muscle	11.4 nTPM
Breast	11.1 nTPM
Esophagus	11.0 nTPM
Adipose tissue	9.6 nTPM
Prostate	9.3 nTPM
Skin	8.9 nTPM
Lung	3.4 nTPM
Heart muscle	2.7 nTPM

Intestinal goblet cells	11.4 nTPM
Small intestine	16.1 nTPM
Rectum	10.3 nTPM
Colon	7.8 nTPM

Macrophages	9.5 nTPM
Testis	15.7 nTPM
Prostate	13.8 nTPM
Bone marrow	13.8 nTPM
Pancreas	12.8 nTPM
Breast	11.9 nTPM
Ovary	11.8 nTPM
Kidney	11.4 nTPM
Skeletal muscle	8.9 nTPM
Stomach	8.8 nTPM
Esophagus	7.9 nTPM
Lung	7.8 nTPM
Spleen	7.2 nTPM
Adipose tissue	6.1 nTPM
Endometrium	4.4 nTPM
PBMC	0.0 nTPM

Paneth cells	15.3 nTPM
Rectum	17.7 nTPM
Small intestine	15.0 nTPM
Colon	13.2 nTPM

Plasma cells	7.7 nTPM
Bone marrow	13.2 nTPM
Stomach	9.8 nTPM
Spleen	8.5 nTPM
Adipose tissue	7.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	11.7 nTPM
Bronchus	16.2 nTPM
Lung	7.3 nTPM

Smooth muscle cells	8.0 nTPM
Breast	13.0 nTPM
Ovary	10.5 nTPM
Pancreas	9.6 nTPM
Skeletal muscle	8.9 nTPM
Adipose tissue	8.5 nTPM
Skin	8.0 nTPM
Esophagus	7.8 nTPM
Heart muscle	6.1 nTPM
Endometrium	6.0 nTPM
Prostate	5.6 nTPM
Bronchus	3.7 nTPM

T-cells	14.0 nTPM
PBMC	32.4 nTPM
Liver	27.0 nTPM
Kidney	23.3 nTPM
Ovary	20.1 nTPM
Colon	20.0 nTPM
Bone marrow	18.8 nTPM
Skeletal muscle	12.7 nTPM
Breast	11.4 nTPM
Stomach	10.7 nTPM
Lung	10.6 nTPM
Skin	9.7 nTPM
Spleen	9.6 nTPM
Adipose tissue	7.4 nTPM
Lymph node	7.0 nTPM
Esophagus	6.6 nTPM
Endometrium	5.4 nTPM
Prostate	4.7 nTPM

Basal squamous epithelial cells	8.6 nTPM
Esophagus	8.6 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Cytotrophoblasts	15.2 nTPM
Placenta	15.2 nTPM

Distal enterocytes	17.3 nTPM
Rectum	19.7 nTPM
Colon	14.9 nTPM

Undifferentiated cells	12.7 nTPM
Colon	12.8 nTPM
Small intestine	12.8 nTPM
Rectum	12.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC