Single cell type - BIRC6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BIRC6
Gene descriptionⁱ Full gene name according to HGNC.	Baculoviral IAP repeat containing 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BIRC6 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.97
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
INTS9	Integrator complex subunit 9	0.6060	59
EXOC2	Exocyst complex component 2	0.5554	8
SSH2	Slingshot protein phosphatase 2	0.5222	59
SPAST	Spastin	0.5212	44
TRPC4AP	Transient receptor potential cation channel subfamily C member 4 associated protein	0.4961	59
SCAF8	SR-related CTD associated factor 8	0.4957	42
FOXJ3	Forkhead box J3	0.4929	44
EED	Embryonic ectoderm development	0.4900	59
SP3	Sp3 transcription factor	0.4870	59
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.4826	8
XKRX	XK related X-linked	0.4822	8
AP4E1	Adaptor related protein complex 4 subunit epsilon 1	0.4763	59
MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1	0.4693	8
XPO4	Exportin 4	0.4674	58
BACH2	BTB domain and CNC homolog 2	0.4643	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.9 nTPM
Adipose tissue	63.6 nTPM
Breast	44.4 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	30.5 nTPM
Lung	30.5 nTPM

Astrocytes	239.3 nTPM
Brain	239.3 nTPM

B-cells	74.8 nTPM
Lymph node	106.3 nTPM
Bone marrow	103.8 nTPM
Adipose tissue	97.3 nTPM
Stomach	95.4 nTPM
Spleen	93.4 nTPM
Kidney	66.6 nTPM
PBMC	54.3 nTPM
Colon	51.1 nTPM
Breast	45.4 nTPM
Liver	34.2 nTPM

Dendritic cells	93.4 nTPM
Adipose tissue	108.0 nTPM
PBMC	103.6 nTPM
Breast	68.5 nTPM

Endothelial cells	49.8 nTPM
Heart muscle	81.1 nTPM
Skeletal muscle	70.2 nTPM
Ovary	70.0 nTPM
Endometrium	62.4 nTPM
Prostate	58.7 nTPM
Testis	57.5 nTPM
Esophagus	54.3 nTPM
Skin	51.5 nTPM
Breast	42.2 nTPM
Placenta	42.0 nTPM
Eye	36.4 nTPM
Lung	31.2 nTPM
Liver	23.8 nTPM
Pancreas	15.5 nTPM

Fibroblasts	39.7 nTPM
Skeletal muscle	52.8 nTPM
Skin	46.1 nTPM
Adipose tissue	43.2 nTPM
Ovary	42.2 nTPM
Stomach	41.6 nTPM
Breast	39.3 nTPM
Prostate	39.0 nTPM
Esophagus	37.1 nTPM
Heart muscle	32.7 nTPM
Lung	31.3 nTPM
Placenta	31.0 nTPM

Intestinal goblet cells	43.3 nTPM
Small intestine	47.2 nTPM
Rectum	44.9 nTPM
Colon	37.8 nTPM

Macrophages	59.1 nTPM
Stomach	114.3 nTPM
Bone marrow	96.2 nTPM
Spleen	95.4 nTPM
Adipose tissue	82.1 nTPM
Esophagus	80.3 nTPM
Skeletal muscle	79.9 nTPM
Ovary	59.5 nTPM
Endometrium	54.7 nTPM
Breast	44.9 nTPM
Kidney	44.7 nTPM
Lung	33.8 nTPM
Testis	32.6 nTPM
Prostate	27.5 nTPM
PBMC	27.3 nTPM
Pancreas	12.8 nTPM

Paneth cells	30.3 nTPM
Rectum	42.5 nTPM
Colon	29.6 nTPM
Small intestine	18.8 nTPM

Plasma cells	70.9 nTPM
Adipose tissue	122.6 nTPM
Bone marrow	75.8 nTPM
Spleen	67.7 nTPM
Stomach	57.9 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	30.6 nTPM
Bronchus	49.6 nTPM
Lung	11.7 nTPM

Smooth muscle cells	49.1 nTPM
Adipose tissue	61.6 nTPM
Skeletal muscle	59.9 nTPM
Heart muscle	59.1 nTPM
Endometrium	57.6 nTPM
Esophagus	54.3 nTPM
Bronchus	50.2 nTPM
Skin	49.1 nTPM
Prostate	44.7 nTPM
Ovary	42.3 nTPM
Breast	38.4 nTPM
Pancreas	23.0 nTPM

T-cells	72.4 nTPM
Skeletal muscle	112.7 nTPM
Adipose tissue	102.4 nTPM
Bone marrow	95.6 nTPM
Spleen	95.0 nTPM
Endometrium	94.1 nTPM
Stomach	83.5 nTPM
Lymph node	82.1 nTPM
Esophagus	78.6 nTPM
Breast	77.0 nTPM
PBMC	71.6 nTPM
Skin	64.4 nTPM
Liver	63.4 nTPM
Colon	61.8 nTPM
Ovary	57.8 nTPM
Kidney	37.6 nTPM
Prostate	28.4 nTPM
Lung	24.3 nTPM

Basal keratinocytes	46.0 nTPM
Skin	46.0 nTPM

Basal prostatic cells	28.6 nTPM
Prostate	28.6 nTPM

Basal respiratory cells	34.7 nTPM
Bronchus	34.7 nTPM

Basal squamous epithelial cells	41.5 nTPM
Esophagus	41.5 nTPM

Undifferentiated cells	45.3 nTPM
Colon	52.3 nTPM
Rectum	45.6 nTPM
Small intestine	38.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC