Single cell type - SPR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPR
Gene descriptionⁱ Full gene name according to HGNC.	Sepiapterin reductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic cells - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal enterocytes, Exocrine glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, classical monocyte, intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal enterocytes, Exocrine glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SPR is part of cluster 1 Pancreatic cells - Digestion with confidenceⁱ 1
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NEURL3	Neuralized E3 ubiquitin protein ligase 3	0.6403	1
AC114490.2	Novel protein	0.5831	1
CFTR	CF transmembrane conductance regulator	0.5819	1
ACOT2	Acyl-CoA thioesterase 2	0.5724	59
TRIM47	Tripartite motif containing 47	0.5586	1
TMED6	Transmembrane p24 trafficking protein 6	0.5550	1
UBD	Ubiquitin D	0.5518	1
MMP7	Matrix metallopeptidase 7	0.5450	1
KCNK16	Potassium two pore domain channel subfamily K member 16	0.5423	1
NPPB	Natriuretic peptide B	0.5350	1
ADH1C	Alcohol dehydrogenase 1C (class I), gamma polypeptide	0.5348	1
CD151	CD151 molecule (Raph blood group)	0.5279	1
SPRR5	Small proline rich protein 5	0.5275	1
HTR3A	5-hydroxytryptamine receptor 3A	0.5237	1
TMEM51	Transmembrane protein 51	0.5213	1

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.8 nTPM
Breast	20.1 nTPM
Adipose tissue	7.7 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	7.3 nTPM
Lung	7.3 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	1.1 nTPM
Colon	4.8 nTPM
Liver	3.3 nTPM
Breast	2.6 nTPM
Spleen	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	0.4 nTPM
Breast	1.1 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	16.7 nTPM
Pancreas	34.7 nTPM
Heart muscle	30.5 nTPM
Liver	28.4 nTPM
Testis	23.4 nTPM
Prostate	20.3 nTPM
Breast	19.2 nTPM
Skin	18.2 nTPM
Esophagus	17.5 nTPM
Placenta	9.7 nTPM
Skeletal muscle	7.8 nTPM
Endometrium	7.6 nTPM
Ovary	7.4 nTPM
Eye	6.5 nTPM
Lung	3.1 nTPM

Fibroblasts	13.9 nTPM
Heart muscle	36.9 nTPM
Esophagus	22.3 nTPM
Skin	16.4 nTPM
Adipose tissue	14.7 nTPM
Prostate	14.1 nTPM
Skeletal muscle	13.9 nTPM
Breast	12.1 nTPM
Stomach	7.4 nTPM
Placenta	5.9 nTPM
Ovary	5.1 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	39.6 nTPM
Small intestine	42.7 nTPM
Rectum	40.3 nTPM
Colon	35.8 nTPM

Macrophages	9.7 nTPM
Pancreas	43.4 nTPM
Kidney	21.9 nTPM
Testis	15.7 nTPM
Ovary	13.4 nTPM
Prostate	9.1 nTPM
Skeletal muscle	6.5 nTPM
Spleen	6.2 nTPM
Lung	5.9 nTPM
Endometrium	5.4 nTPM
Breast	5.4 nTPM
Bone marrow	3.7 nTPM
Adipose tissue	3.4 nTPM
Esophagus	3.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	50.4 nTPM
Colon	59.3 nTPM
Rectum	58.1 nTPM
Small intestine	33.8 nTPM

Plasma cells	1.4 nTPM
Stomach	3.5 nTPM
Spleen	2.6 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	11.2 nTPM
Bronchus	15.2 nTPM
Lung	7.3 nTPM

Smooth muscle cells	8.6 nTPM
Pancreas	19.1 nTPM
Heart muscle	15.0 nTPM
Prostate	14.0 nTPM
Esophagus	14.0 nTPM
Breast	9.4 nTPM
Skin	7.7 nTPM
Adipose tissue	5.4 nTPM
Bronchus	3.8 nTPM
Skeletal muscle	2.7 nTPM
Ovary	2.2 nTPM
Endometrium	1.4 nTPM

T-cells	1.9 nTPM
Prostate	9.5 nTPM
Esophagus	6.6 nTPM
Kidney	6.2 nTPM
Skin	1.9 nTPM
Liver	1.6 nTPM
Breast	1.5 nTPM
Colon	1.4 nTPM
Endometrium	1.2 nTPM
PBMC	0.5 nTPM
Skeletal muscle	0.5 nTPM
Spleen	0.5 nTPM
Adipose tissue	0.2 nTPM
Bone marrow	0.1 nTPM
Lung	0.0 nTPM
Ovary	0.0 nTPM
Lymph node	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	8.4 nTPM
Skin	8.4 nTPM

Basal prostatic cells	23.0 nTPM
Prostate	23.0 nTPM

Basal respiratory cells	14.8 nTPM
Bronchus	14.8 nTPM

Basal squamous epithelial cells	20.5 nTPM
Esophagus	20.5 nTPM

Undifferentiated cells	57.8 nTPM
Small intestine	62.3 nTPM
Rectum	55.9 nTPM
Colon	55.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC