Single cell type - DHCR24 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHCR24
Gene descriptionⁱ Full gene name according to HGNC.	24-dehydrocholesterol reductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Hepatocytes - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Alveolar cells type 2, Theca cells, Alveolar cells type 1)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Alveolar cells type 2, Theca cells, Alveolar cells type 1)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DHCR24 is part of cluster 15 Hepatocytes - Hemostasis with confidenceⁱ 1
129 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C4BPA	Complement component 4 binding protein alpha	0.8981	15
PCSK9	Proprotein convertase subtilisin/kexin type 9	0.8367	15
F11	Coagulation factor XI	0.8355	15
SCD	Stearoyl-CoA desaturase	0.7781	15
SAA2	Serum amyloid A2	0.7467	15
MSMO1	Methylsterol monooxygenase 1	0.7383	15
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	0.7350	15
SAA1	Serum amyloid A1	0.7327	15
SAA2-SAA4	SAA2-SAA4 readthrough	0.7181	15
CFHR1	Complement factor H related 1	0.7062	15
CFHR3	Complement factor H related 3	0.7036	15
CFHR4	Complement factor H related 4	0.6989	15
ANGPTL8	Angiopoietin like 8	0.6953	15
CRP	C-reactive protein	0.6942	15
FGG	Fibrinogen gamma chain	0.6930	15

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.2 nTPM
Breast	6.6 nTPM
Adipose tissue	5.7 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	13.3 nTPM
Liver	108.9 nTPM
Colon	12.8 nTPM
Breast	5.3 nTPM
Stomach	1.8 nTPM
Bone marrow	1.7 nTPM
PBMC	1.4 nTPM
Spleen	0.7 nTPM
Adipose tissue	0.5 nTPM
Lymph node	0.4 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	31.5 nTPM
Skin	31.5 nTPM

Basal prostatic cells	17.3 nTPM
Prostate	17.3 nTPM

Dendritic cells	6.4 nTPM
PBMC	8.0 nTPM
Breast	5.8 nTPM
Adipose tissue	5.3 nTPM

Endothelial cells	13.5 nTPM
Liver	36.7 nTPM
Placenta	29.6 nTPM
Lung	28.1 nTPM
Ovary	19.2 nTPM
Heart muscle	17.1 nTPM
Breast	14.7 nTPM
Skin	10.9 nTPM
Esophagus	10.8 nTPM
Endometrium	7.3 nTPM
Skeletal muscle	6.1 nTPM
Prostate	3.5 nTPM
Eye	2.4 nTPM
Testis	2.1 nTPM
Pancreas	0.0 nTPM

Fibroblasts	17.5 nTPM
Lung	50.3 nTPM
Ovary	40.0 nTPM
Placenta	32.2 nTPM
Stomach	16.3 nTPM
Skin	15.8 nTPM
Esophagus	9.3 nTPM
Adipose tissue	7.0 nTPM
Breast	7.0 nTPM
Prostate	6.2 nTPM
Heart muscle	6.1 nTPM
Skeletal muscle	2.8 nTPM

Intestinal goblet cells	39.2 nTPM
Rectum	41.0 nTPM
Small intestine	40.2 nTPM
Colon	36.4 nTPM

Macrophages	9.4 nTPM
Lung	51.1 nTPM
Ovary	46.7 nTPM
Pancreas	12.8 nTPM
Endometrium	5.4 nTPM
Prostate	4.6 nTPM
Breast	4.1 nTPM
Kidney	3.8 nTPM
Esophagus	3.1 nTPM
Stomach	2.9 nTPM
Testis	2.3 nTPM
Skeletal muscle	2.3 nTPM
Adipose tissue	1.1 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	27.7 nTPM
Colon	39.6 nTPM
Rectum	28.7 nTPM
Small intestine	15.0 nTPM

Plasma cells	1.8 nTPM
Spleen	4.2 nTPM
Adipose tissue	1.9 nTPM
Bone marrow	1.7 nTPM
Stomach	1.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	136.3 nTPM
Bronchus	169.1 nTPM
Lung	103.5 nTPM

Smooth muscle cells	23.2 nTPM
Ovary	126.0 nTPM
Bronchus	74.7 nTPM
Pancreas	23.6 nTPM
Heart muscle	11.8 nTPM
Breast	4.2 nTPM
Endometrium	4.0 nTPM
Skin	3.8 nTPM
Prostate	2.8 nTPM
Esophagus	1.5 nTPM
Adipose tissue	1.4 nTPM
Skeletal muscle	1.2 nTPM

T-cells	10.6 nTPM
Lung	79.0 nTPM
Liver	42.2 nTPM
Ovary	8.9 nTPM
Kidney	7.5 nTPM
Skin	7.4 nTPM
Endometrium	7.0 nTPM
Esophagus	6.6 nTPM
Colon	5.7 nTPM
Breast	4.6 nTPM
Stomach	2.9 nTPM
Spleen	2.2 nTPM
Adipose tissue	1.7 nTPM
Skeletal muscle	1.5 nTPM
Bone marrow	1.5 nTPM
PBMC	1.2 nTPM
Lymph node	0.4 nTPM
Prostate	0.0 nTPM

Cholangiocytes	145.8 nTPM
Liver	145.8 nTPM

Collecting duct cells	68.0 nTPM
Kidney	68.0 nTPM

Cytotrophoblasts	35.2 nTPM
Placenta	35.2 nTPM

Distal enterocytes	133.3 nTPM
Rectum	147.7 nTPM
Colon	118.9 nTPM

Undifferentiated cells	35.2 nTPM
Colon	51.6 nTPM
Rectum	34.6 nTPM
Small intestine	19.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC