Single cell type - SIPA1L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SIPA1L2
Gene descriptionⁱ Full gene name according to HGNC.	Signal induced proliferation associated 1 like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22, NTERA-2, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SIPA1L2 is part of cluster 68 Oligodendrocytes - Mixed function with confidenceⁱ 1
161 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLOCK	Clock circadian regulator	0.5475	52
MCU	Mitochondrial calcium uniporter	0.5210	8
RNF150	Ring finger protein 150	0.5176	8
LARP4B	La ribonucleoprotein 4B	0.4698	44
MARK1	Microtubule affinity regulating kinase 1	0.4636	8
SCYL2	SCY1 like pseudokinase 2	0.4610	59
SERINC5	Serine incorporator 5	0.4526	22
PHACTR4	Phosphatase and actin regulator 4	0.4504	44
RALGAPA2	Ral GTPase activating protein catalytic subunit alpha 2	0.4490	44
CA8	Carbonic anhydrase 8	0.4488	68
CSMD2	CUB and Sushi multiple domains 2	0.4476	8
PTPRG	Protein tyrosine phosphatase receptor type G	0.4463	68
NOS1	Nitric oxide synthase 1	0.4446	8
TRAK1	Trafficking kinesin protein 1	0.4429	46
MFHAS1	Malignant fibrous histiocytoma amplified sequence 1	0.4416	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	53.7 nTPM
Adipose tissue	70.7 nTPM
Breast	36.7 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	1.8 nTPM
Lung	1.8 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	0.8 nTPM
Colon	3.2 nTPM
Breast	2.6 nTPM
Adipose tissue	1.5 nTPM
Liver	0.4 nTPM
Lymph node	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	4.4 nTPM
PBMC	12.0 nTPM
Adipose tissue	0.9 nTPM
Breast	0.4 nTPM

Endothelial cells	22.7 nTPM
Ovary	42.9 nTPM
Prostate	34.9 nTPM
Skeletal muscle	31.7 nTPM
Eye	28.3 nTPM
Placenta	27.8 nTPM
Endometrium	26.6 nTPM
Lung	24.9 nTPM
Breast	24.7 nTPM
Pancreas	23.1 nTPM
Skin	17.7 nTPM
Esophagus	17.1 nTPM
Heart muscle	15.0 nTPM
Testis	2.4 nTPM
Liver	0.9 nTPM

Fibroblasts	15.2 nTPM
Ovary	28.9 nTPM
Breast	21.1 nTPM
Heart muscle	19.1 nTPM
Adipose tissue	17.3 nTPM
Skin	15.5 nTPM
Placenta	14.1 nTPM
Lung	13.4 nTPM
Esophagus	11.9 nTPM
Prostate	11.7 nTPM
Skeletal muscle	11.5 nTPM
Stomach	3.0 nTPM

Intestinal goblet cells	29.5 nTPM
Rectum	42.6 nTPM
Colon	32.2 nTPM
Small intestine	13.8 nTPM

Macrophages	19.5 nTPM
Ovary	36.7 nTPM
Lung	31.2 nTPM
Stomach	29.4 nTPM
Adipose tissue	27.3 nTPM
Esophagus	26.8 nTPM
Skeletal muscle	22.0 nTPM
Spleen	20.7 nTPM
Testis	17.4 nTPM
Breast	16.6 nTPM
Endometrium	15.1 nTPM
Bone marrow	15.0 nTPM
Pancreas	12.8 nTPM
Kidney	11.4 nTPM
Prostate	10.3 nTPM
PBMC	0.0 nTPM

Paneth cells	39.9 nTPM
Rectum	62.5 nTPM
Small intestine	37.6 nTPM
Colon	19.7 nTPM

Plasma cells	0.5 nTPM
Adipose tissue	1.3 nTPM
Spleen	0.7 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	7.7 nTPM
Bronchus	9.5 nTPM
Lung	5.8 nTPM

Smooth muscle cells	23.9 nTPM
Ovary	48.0 nTPM
Endometrium	44.0 nTPM
Heart muscle	31.1 nTPM
Skin	26.2 nTPM
Esophagus	24.8 nTPM
Breast	22.7 nTPM
Adipose tissue	22.6 nTPM
Prostate	22.2 nTPM
Skeletal muscle	18.0 nTPM
Bronchus	2.9 nTPM
Pancreas	1.0 nTPM

T-cells	2.0 nTPM
Adipose tissue	7.6 nTPM
Endometrium	5.6 nTPM
Skeletal muscle	4.2 nTPM
Colon	3.3 nTPM
Breast	2.6 nTPM
Ovary	2.2 nTPM
Skin	1.9 nTPM
PBMC	1.7 nTPM
Lung	1.5 nTPM
Kidney	1.4 nTPM
Liver	1.1 nTPM
Spleen	1.0 nTPM
Stomach	0.3 nTPM
Lymph node	0.2 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	8.8 nTPM
Skin	8.8 nTPM

Basal prostatic cells	9.8 nTPM
Prostate	9.8 nTPM

Basal respiratory cells	8.7 nTPM
Bronchus	8.7 nTPM

Basal squamous epithelial cells	15.4 nTPM
Esophagus	15.4 nTPM

Undifferentiated cells	23.4 nTPM
Rectum	29.3 nTPM
Colon	27.9 nTPM
Small intestine	13.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC