Single cell type - PIK3R3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIK3R3
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoinositide-3-kinase regulatory subunit 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Metabolic proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Adipocytes, Endothelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Adipocytes, Endothelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIK3R3 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
JAG2	Jagged canonical Notch ligand 2	0.7895	14
C1QTNF9	C1q and TNF related 9	0.7602	14
FABP9	Fatty acid binding protein 9	0.7550	14
TPO	Thyroid peroxidase	0.7439	14
TNFRSF10D	TNF receptor superfamily member 10d	0.7288	14
CYYR1	Cysteine and tyrosine rich 1	0.7019	14
GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.6990	14
FAM107A	Family with sequence similarity 107 member A	0.6987	14
PTPRB	Protein tyrosine phosphatase receptor type B	0.6763	14
MMRN2	Multimerin 2	0.6755	14
SEMA3G	Semaphorin 3G	0.6748	14
CLEC14A	C-type lectin domain containing 14A	0.6719	14
PALMD	Palmdelphin	0.6706	14
MEOX1	Mesenchyme homeobox 1	0.6663	14
EMCN	Endomucin	0.6653	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	8.4 nTPM
Lung	8.4 nTPM

Astrocytes	15.7 nTPM
Brain	15.7 nTPM

B-cells	3.1 nTPM
Breast	18.7 nTPM
Colon	4.8 nTPM
Lymph node	2.7 nTPM
Stomach	2.7 nTPM
Spleen	1.7 nTPM
Adipose tissue	0.5 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	2.5 nTPM
Skin	2.5 nTPM

Adipocytes	199.0 nTPM
Adipose tissue	259.7 nTPM
Breast	138.3 nTPM

Dendritic cells	13.9 nTPM
Breast	25.5 nTPM
Adipose tissue	16.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	83.3 nTPM
Esophagus	263.0 nTPM
Skeletal muscle	251.7 nTPM
Heart muscle	149.7 nTPM
Eye	82.5 nTPM
Testis	81.2 nTPM
Breast	66.7 nTPM
Endometrium	50.9 nTPM
Ovary	48.2 nTPM
Lung	46.8 nTPM
Skin	43.1 nTPM
Prostate	41.9 nTPM
Placenta	36.4 nTPM
Pancreas	3.9 nTPM
Liver	0.0 nTPM

Fibroblasts	16.2 nTPM
Stomach	41.6 nTPM
Esophagus	41.5 nTPM
Breast	24.3 nTPM
Ovary	19.2 nTPM
Heart muscle	17.0 nTPM
Prostate	11.0 nTPM
Skeletal muscle	8.5 nTPM
Lung	7.8 nTPM
Skin	5.5 nTPM
Placenta	1.5 nTPM
Adipose tissue	0.4 nTPM

Intestinal goblet cells	8.6 nTPM
Colon	22.8 nTPM
Small intestine	2.1 nTPM
Rectum	0.9 nTPM

Macrophages	8.4 nTPM
Breast	44.9 nTPM
Esophagus	17.3 nTPM
Prostate	11.5 nTPM
Skeletal muscle	11.1 nTPM
Endometrium	10.6 nTPM
Stomach	8.8 nTPM
Spleen	7.2 nTPM
Adipose tissue	4.2 nTPM
Ovary	3.9 nTPM
Kidney	2.3 nTPM
Lung	2.0 nTPM
Testis	1.7 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	1.5 nTPM
Colon	3.3 nTPM
Rectum	1.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	10.1 nTPM
Stomach	22.5 nTPM
Esophagus	18.4 nTPM
Adipose tissue	7.8 nTPM
Spleen	1.9 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	26.7 nTPM
Bronchus	34.4 nTPM
Lung	19.0 nTPM

Smooth muscle cells	18.0 nTPM
Esophagus	40.3 nTPM
Heart muscle	28.1 nTPM
Breast	27.2 nTPM
Endometrium	25.3 nTPM
Bronchus	19.7 nTPM
Skin	15.7 nTPM
Prostate	14.0 nTPM
Skeletal muscle	14.0 nTPM
Ovary	9.2 nTPM
Adipose tissue	3.1 nTPM
Pancreas	1.2 nTPM

Cone photoreceptor cells	45.9 nTPM
Eye	45.9 nTPM

Cytotrophoblasts	4.4 nTPM
Placenta	4.4 nTPM

Distal enterocytes	21.7 nTPM
Colon	37.6 nTPM
Rectum	5.8 nTPM

Early spermatids	11.8 nTPM
Testis	11.8 nTPM

T-cells	15.7 nTPM
Prostate	85.2 nTPM
Esophagus	45.9 nTPM
Skeletal muscle	21.4 nTPM
Stomach	19.6 nTPM
Breast	16.0 nTPM
Endometrium	13.9 nTPM
Colon	13.8 nTPM
Spleen	12.7 nTPM
Lymph node	8.2 nTPM
Kidney	7.5 nTPM
Adipose tissue	5.7 nTPM
Bone marrow	5.4 nTPM
Ovary	4.5 nTPM
Skin	3.6 nTPM
Lung	1.5 nTPM
PBMC	1.4 nTPM
Liver	0.0 nTPM

Undifferentiated cells	6.6 nTPM
Colon	16.6 nTPM
Small intestine	1.9 nTPM
Rectum	1.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC