Single cell type - PROX1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PROX1
Gene descriptionⁱ Full gene name according to HGNC.	Prospero homeobox 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Horizontal cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells, Hepatocytes, Bipolar cells, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Hep G2, RH-30, SH-SY5Y)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells, Hepatocytes, Bipolar cells, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PROX1 is part of cluster 62 Horizontal cells - Visual perception with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CHRNA4	Cholinergic receptor nicotinic alpha 4 subunit	0.6241	62
TMEM179	Transmembrane protein 179	0.5708	62
KCNJ2	Potassium inwardly rectifying channel subfamily J member 2	0.5577	62
SCG3	Secretogranin III	0.5436	62
DRD1	Dopamine receptor D1	0.5369	62
DHODH	Dihydroorotate dehydrogenase (quinone)	0.5336	15
IGLON5	IgLON family member 5	0.5176	62
STAB2	Stabilin 2	0.5161	14
CCL21	C-C motif chemokine ligand 21	0.5161	14
JPH4	Junctophilin 4	0.5131	62
DTX1	Deltex E3 ubiquitin ligase 1	0.5114	62
SEZ6	Seizure related 6 homolog	0.5114	56
MMRN1	Multimerin 1	0.5108	14
CRMP1	Collapsin response mediator protein 1	0.5007	62
DRD2	Dopamine receptor D2	0.4987	62

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.3 nTPM
Adipose tissue	19.9 nTPM
Breast	8.8 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	2.3 nTPM
Lung	2.3 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	1.9 nTPM
Breast	5.3 nTPM
Liver	4.2 nTPM
Spleen	3.1 nTPM
Adipose tissue	3.0 nTPM
Lymph node	1.8 nTPM
Stomach	1.4 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	0.1 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	36.5 nTPM
Lung	171.5 nTPM
Skin	113.9 nTPM
Endometrium	41.6 nTPM
Breast	35.4 nTPM
Esophagus	33.7 nTPM
Placenta	25.0 nTPM
Testis	19.3 nTPM
Heart muscle	17.0 nTPM
Prostate	16.9 nTPM
Skeletal muscle	14.0 nTPM
Pancreas	11.6 nTPM
Ovary	7.0 nTPM
Eye	2.4 nTPM
Liver	0.9 nTPM

Fibroblasts	8.7 nTPM
Heart muscle	31.2 nTPM
Skin	11.8 nTPM
Esophagus	11.3 nTPM
Ovary	9.6 nTPM
Lung	8.9 nTPM
Prostate	7.6 nTPM
Stomach	7.4 nTPM
Skeletal muscle	4.2 nTPM
Adipose tissue	2.2 nTPM
Breast	1.5 nTPM
Placenta	0.1 nTPM

Intestinal goblet cells	16.5 nTPM
Small intestine	22.1 nTPM
Rectum	16.6 nTPM
Colon	10.7 nTPM

Macrophages	2.2 nTPM
Esophagus	9.4 nTPM
Breast	6.1 nTPM
Prostate	4.6 nTPM
Skeletal muscle	4.5 nTPM
Adipose tissue	4.4 nTPM
Testis	1.2 nTPM
Lung	1.1 nTPM
Spleen	1.0 nTPM
Ovary	0.9 nTPM
Endometrium	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	130.6 nTPM
Small intestine	277.9 nTPM
Rectum	87.6 nTPM
Colon	26.4 nTPM

Plasma cells	0.1 nTPM
Spleen	0.3 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	0.9 nTPM
Lung	1.5 nTPM
Bronchus	0.4 nTPM

Smooth muscle cells	3.7 nTPM
Ovary	13.6 nTPM
Heart muscle	8.2 nTPM
Skin	6.4 nTPM
Adipose tissue	3.7 nTPM
Prostate	3.2 nTPM
Skeletal muscle	1.7 nTPM
Endometrium	1.6 nTPM
Breast	1.6 nTPM
Pancreas	0.9 nTPM
Bronchus	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	1.9 nTPM
Esophagus	19.7 nTPM
Liver	5.4 nTPM
Skeletal muscle	4.4 nTPM
Skin	2.3 nTPM
Endometrium	0.4 nTPM
Breast	0.3 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	5.9 nTPM
Skin	5.9 nTPM

Basal squamous epithelial cells	5.7 nTPM
Esophagus	5.7 nTPM

Cholangiocytes	102.9 nTPM
Liver	102.9 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	10.5 nTPM
Small intestine	13.6 nTPM
Colon	9.7 nTPM
Rectum	8.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC