Single cell type - OSBPL9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSBPL9
Gene descriptionⁱ Full gene name according to HGNC.	Oxysterol binding protein like 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OSBPL9 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAGED1	MAGE family member D1	0.4642	47
SLC35B4	Solute carrier family 35 member B4	0.4620	47
PDSS2	Decaprenyl diphosphate synthase subunit 2	0.4604	42
BEX3	Brain expressed X-linked 3	0.4422	47
SORCS2	Sortilin related VPS10 domain containing receptor 2	0.4419	56
SERPINI1	Serpin family I member 1	0.4406	56
USP48	Ubiquitin specific peptidase 48	0.4383	40
TCEAL9	Transcription elongation factor A like 9	0.4293	47
TRPC1	Transient receptor potential cation channel subfamily C member 1	0.4207	40
XPA	XPA, DNA damage recognition and repair factor	0.4126	52
RASA1	RAS p21 protein activator 1	0.4112	18
FUT8	Fucosyltransferase 8	0.4083	42
USP27X	Ubiquitin specific peptidase 27 X-linked	0.4007	47
TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1	0.3984	56
HHATL	Hedgehog acyltransferase like	0.3980	56

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.5 nTPM
Adipose tissue	34.5 nTPM
Breast	30.3 nTPM

Alveolar cells type 1	80.1 nTPM
Lung	80.1 nTPM

Alveolar cells type 2	56.8 nTPM
Lung	56.8 nTPM

Astrocytes	75.4 nTPM
Brain	75.4 nTPM

B-cells	39.2 nTPM
Stomach	62.2 nTPM
Lymph node	57.9 nTPM
Bone marrow	51.5 nTPM
Spleen	47.1 nTPM
Adipose tissue	36.0 nTPM
PBMC	35.7 nTPM
Liver	33.6 nTPM
Breast	28.1 nTPM
Colon	20.8 nTPM
Kidney	19.0 nTPM

Dendritic cells	30.4 nTPM
Adipose tissue	37.7 nTPM
PBMC	35.8 nTPM
Breast	17.5 nTPM

Endothelial cells	30.1 nTPM
Lung	53.0 nTPM
Endometrium	39.0 nTPM
Testis	36.4 nTPM
Heart muscle	35.1 nTPM
Esophagus	34.9 nTPM
Placenta	34.1 nTPM
Ovary	31.9 nTPM
Skeletal muscle	29.7 nTPM
Eye	26.7 nTPM
Breast	24.4 nTPM
Pancreas	23.1 nTPM
Prostate	21.0 nTPM
Skin	19.2 nTPM
Liver	12.8 nTPM

Fibroblasts	48.6 nTPM
Heart muscle	97.7 nTPM
Adipose tissue	60.7 nTPM
Esophagus	54.1 nTPM
Lung	50.3 nTPM
Prostate	45.6 nTPM
Placenta	44.2 nTPM
Breast	42.0 nTPM
Stomach	41.6 nTPM
Skeletal muscle	40.5 nTPM
Ovary	31.6 nTPM
Skin	26.1 nTPM

Intestinal goblet cells	18.3 nTPM
Rectum	25.1 nTPM
Small intestine	16.3 nTPM
Colon	13.6 nTPM

Macrophages	25.3 nTPM
Adipose tissue	40.6 nTPM
Ovary	37.7 nTPM
Skeletal muscle	32.9 nTPM
Lung	30.2 nTPM
Spleen	29.0 nTPM
Esophagus	28.3 nTPM
Bone marrow	27.5 nTPM
Breast	24.9 nTPM
Endometrium	24.3 nTPM
Prostate	24.1 nTPM
Testis	22.1 nTPM
Kidney	21.9 nTPM
Stomach	20.5 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	14.3 nTPM
Rectum	25.4 nTPM
Colon	9.9 nTPM
Small intestine	7.5 nTPM

Plasma cells	81.4 nTPM
Stomach	126.7 nTPM
Bone marrow	92.3 nTPM
Spleen	81.0 nTPM
Esophagus	61.7 nTPM
Adipose tissue	45.2 nTPM

Respiratory ciliated cells	32.1 nTPM
Lung	37.9 nTPM
Bronchus	26.3 nTPM

Smooth muscle cells	62.9 nTPM
Heart muscle	115.6 nTPM
Endometrium	81.5 nTPM
Esophagus	76.0 nTPM
Breast	70.5 nTPM
Adipose tissue	65.4 nTPM
Ovary	61.3 nTPM
Bronchus	54.1 nTPM
Skin	46.7 nTPM
Pancreas	42.1 nTPM
Prostate	39.7 nTPM
Skeletal muscle	38.7 nTPM

T-cells	32.0 nTPM
Lymph node	47.2 nTPM
Stomach	45.9 nTPM
Adipose tissue	42.2 nTPM
Spleen	40.1 nTPM
Lung	38.0 nTPM
Bone marrow	37.1 nTPM
Endometrium	33.1 nTPM
Kidney	30.7 nTPM
Skeletal muscle	29.8 nTPM
Prostate	28.4 nTPM
PBMC	27.5 nTPM
Breast	27.5 nTPM
Ovary	26.7 nTPM
Colon	25.6 nTPM
Liver	24.8 nTPM
Skin	20.2 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	17.7 nTPM
Skin	17.7 nTPM

Basal prostatic cells	33.8 nTPM
Prostate	33.8 nTPM

Basal respiratory cells	25.7 nTPM
Bronchus	25.7 nTPM

Cholangiocytes	38.6 nTPM
Liver	38.6 nTPM

Undifferentiated cells	21.2 nTPM
Rectum	26.4 nTPM
Small intestine	22.0 nTPM
Colon	15.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC