Single cell type - CSF3R - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CSF3R
Gene descriptionⁱ Full gene name according to HGNC.	Colony stimulating factor 3 receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Syncytiotrophoblasts - Pregnancy hormone signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Alveolar cells type 2, monocytes, Kupffer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (BEWO, NB-4, THP-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Alveolar cells type 2, monocytes, Kupffer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CSF3R is part of cluster 18 Syncytiotrophoblasts - Pregnancy hormone signaling with confidenceⁱ 1
186 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC19A1	Solute carrier family 19 member 1	0.8948	18
SLC43A2	Solute carrier family 43 member 2	0.8634	18
SLC13A4	Solute carrier family 13 member 4	0.8607	18
NFE2L3	Nuclear factor, erythroid 2 like 3	0.8569	18
ERVW-1	Endogenous retrovirus group W member 1, envelope	0.8551	18
SLC22A11	Solute carrier family 22 member 11	0.8543	18
DACT2	Dishevelled binding antagonist of beta catenin 2	0.8480	18
MLLT1	MLLT1 super elongation complex subunit	0.8384	18
SLC19A3	Solute carrier family 19 member 3	0.8343	18
GSTA3	Glutathione S-transferase alpha 3	0.8322	18
SLC52A1	Solute carrier family 52 member 1	0.8272	18
INSL4	Insulin like 4	0.8233	18
CALHM4	Calcium homeostasis modulator family member 4	0.8232	18
LGALS14	Galectin 14	0.8102	18
KCNN4	Potassium calcium-activated channel subfamily N member 4	0.8073	18

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.7 nTPM
Adipose tissue	0.7 nTPM
Breast	0.7 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	3.3 nTPM
Breast	13.4 nTPM
Colon	9.6 nTPM
Liver	3.3 nTPM
PBMC	2.8 nTPM
Spleen	2.1 nTPM
Lymph node	0.8 nTPM
Bone marrow	0.8 nTPM
Kidney	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	1.0 nTPM
Skin	1.0 nTPM

Dendritic cells	2.9 nTPM
PBMC	8.0 nTPM
Adipose tissue	0.7 nTPM
Breast	0.0 nTPM

Endothelial cells	4.8 nTPM
Eye	29.1 nTPM
Placenta	17.6 nTPM
Lung	12.5 nTPM
Liver	3.7 nTPM
Heart muscle	1.6 nTPM
Skin	1.0 nTPM
Breast	1.0 nTPM
Skeletal muscle	0.6 nTPM
Prostate	0.1 nTPM
Endometrium	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Fibroblasts	8.0 nTPM
Lung	45.8 nTPM
Placenta	32.4 nTPM
Prostate	3.4 nTPM
Heart muscle	3.3 nTPM
Breast	1.5 nTPM
Skeletal muscle	1.1 nTPM
Skin	0.4 nTPM
Adipose tissue	0.3 nTPM
Esophagus	0.1 nTPM
Ovary	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	111.5 nTPM
Stomach	228.5 nTPM
Skeletal muscle	180.3 nTPM
Kidney	155.8 nTPM
Spleen	155.5 nTPM
Bone marrow	148.7 nTPM
Lung	132.2 nTPM
Testis	125.0 nTPM
Adipose tissue	113.0 nTPM
Prostate	97.4 nTPM
Endometrium	87.5 nTPM
Ovary	74.1 nTPM
Breast	69.2 nTPM
Esophagus	53.5 nTPM
Pancreas	38.3 nTPM
PBMC	13.6 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.7 nTPM
Adipose tissue	3.3 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	6.6 nTPM
Lung	13.1 nTPM
Bronchus	0.2 nTPM

Smooth muscle cells	1.0 nTPM
Heart muscle	4.1 nTPM
Esophagus	3.1 nTPM
Breast	1.3 nTPM
Skeletal muscle	0.7 nTPM
Endometrium	0.5 nTPM
Prostate	0.4 nTPM
Skin	0.3 nTPM
Adipose tissue	0.2 nTPM
Pancreas	0.0 nTPM
Bronchus	0.0 nTPM
Ovary	0.0 nTPM

T-cells	4.0 nTPM
Lung	48.6 nTPM
PBMC	9.2 nTPM
Skeletal muscle	2.5 nTPM
Spleen	1.5 nTPM
Kidney	1.4 nTPM
Breast	1.0 nTPM
Liver	0.7 nTPM
Bone marrow	0.6 nTPM
Skin	0.5 nTPM
Endometrium	0.5 nTPM
Adipose tissue	0.3 nTPM
Lymph node	0.2 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Cytotrophoblasts	423.8 nTPM
Placenta	423.8 nTPM

Endometrial stromal cells	6.4 nTPM
Endometrium	6.4 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC