Single cell type - IFI27L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IFI27L2
Gene descriptionⁱ Full gene name according to HGNC.	Interferon alpha inducible protein 27 like 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IFI27L2 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 0.98
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RTL3	Retrotransposon Gag like 3	0.5267	50
PDZD11	PDZ domain containing 11	0.5021	39
TYRP1	Tyrosinase related protein 1	0.4896	48
ITGB1BP1	Integrin subunit beta 1 binding protein 1	0.4866	50
POLR3GL	RNA polymerase III subunit GL	0.4816	63
COX6B1	Cytochrome c oxidase subunit 6B1	0.4674	39
SP5	Sp5 transcription factor	0.4669	50
UBE2L6	Ubiquitin conjugating enzyme E2 L6	0.4562	63
IGLL5	Immunoglobulin lambda like polypeptide 5	0.4529	48
DCD	Dermcidin	0.4463	48
EID1	EP300 interacting inhibitor of differentiation 1	0.4433	39
VEGFB	Vascular endothelial growth factor B	0.4428	50
MLANA	Melan-A	0.4387	48
DCT	Dopachrome tautomerase	0.4364	48
QPCT	Glutaminyl-peptide cyclotransferase	0.4344	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	86.5 nTPM
Breast	114.6 nTPM
Adipose tissue	58.4 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	50.9 nTPM
Lung	50.9 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	71.8 nTPM
Liver	134.1 nTPM
Breast	108.2 nTPM
Colon	100.6 nTPM
PBMC	77.1 nTPM
Kidney	76.1 nTPM
Adipose tissue	62.1 nTPM
Spleen	55.4 nTPM
Stomach	45.4 nTPM
Lymph node	30.8 nTPM
Bone marrow	27.8 nTPM

Basal squamous epithelial cells	111.0 nTPM
Esophagus	111.0 nTPM

Dendritic cells	79.3 nTPM
Breast	96.9 nTPM
Adipose tissue	85.1 nTPM
PBMC	55.8 nTPM

Endothelial cells	70.1 nTPM
Testis	137.8 nTPM
Liver	123.8 nTPM
Breast	99.1 nTPM
Heart muscle	95.3 nTPM
Eye	91.4 nTPM
Skin	66.9 nTPM
Skeletal muscle	62.9 nTPM
Placenta	60.8 nTPM
Lung	56.1 nTPM
Pancreas	50.2 nTPM
Endometrium	38.9 nTPM
Ovary	33.3 nTPM
Esophagus	32.5 nTPM
Prostate	32.0 nTPM

Enteroendocrine cells	99.6 nTPM
Rectum	106.8 nTPM
Colon	92.4 nTPM

Fibroblasts	133.0 nTPM
Breast	251.9 nTPM
Esophagus	214.3 nTPM
Skin	212.1 nTPM
Adipose tissue	188.0 nTPM
Stomach	139.6 nTPM
Heart muscle	123.4 nTPM
Skeletal muscle	112.4 nTPM
Ovary	96.1 nTPM
Placenta	76.5 nTPM
Prostate	31.3 nTPM
Lung	17.9 nTPM

Intestinal goblet cells	193.8 nTPM
Colon	252.3 nTPM
Small intestine	207.0 nTPM
Rectum	122.2 nTPM

Macrophages	119.1 nTPM
Kidney	227.6 nTPM
Pancreas	191.4 nTPM
Testis	173.1 nTPM
PBMC	163.7 nTPM
Lung	117.3 nTPM
Ovary	116.2 nTPM
Prostate	99.7 nTPM
Breast	98.5 nTPM
Skeletal muscle	94.2 nTPM
Adipose tissue	94.2 nTPM
Endometrium	88.5 nTPM
Stomach	85.0 nTPM
Spleen	80.9 nTPM
Bone marrow	78.8 nTPM
Esophagus	77.1 nTPM

Paneth cells	150.2 nTPM
Small intestine	206.5 nTPM
Colon	141.6 nTPM
Rectum	102.6 nTPM

Plasma cells	104.4 nTPM
Stomach	157.4 nTPM
Esophagus	141.5 nTPM
Spleen	82.6 nTPM
Adipose tissue	76.2 nTPM
Bone marrow	64.2 nTPM

Respiratory ciliated cells	61.8 nTPM
Bronchus	103.3 nTPM
Lung	20.4 nTPM

Cholangiocytes	50.1 nTPM
Liver	50.1 nTPM

Collecting duct cells	178.4 nTPM
Kidney	178.4 nTPM

Cone photoreceptor cells	20.9 nTPM
Eye	20.9 nTPM

Cytotrophoblasts	2.3 nTPM
Placenta	2.3 nTPM

Smooth muscle cells	87.7 nTPM
Pancreas	174.0 nTPM
Breast	111.7 nTPM
Heart muscle	110.0 nTPM
Esophagus	99.2 nTPM
Skin	86.1 nTPM
Ovary	82.0 nTPM
Adipose tissue	81.1 nTPM
Endometrium	76.8 nTPM
Skeletal muscle	70.7 nTPM
Prostate	40.0 nTPM
Bronchus	32.9 nTPM

T-cells	92.2 nTPM
Kidney	145.1 nTPM
Colon	138.3 nTPM
Liver	122.0 nTPM
Stomach	105.6 nTPM
Skin	98.9 nTPM
PBMC	93.3 nTPM
Adipose tissue	92.8 nTPM
Breast	92.5 nTPM
Lung	86.6 nTPM
Endometrium	86.6 nTPM
Bone marrow	86.0 nTPM
Skeletal muscle	84.1 nTPM
Esophagus	78.6 nTPM
Ovary	75.7 nTPM
Spleen	71.7 nTPM
Prostate	71.1 nTPM
Lymph node	39.5 nTPM

Undifferentiated cells	82.8 nTPM
Small intestine	101.3 nTPM
Colon	74.3 nTPM
Rectum	72.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC