Single cell type - KIAA1217 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KIAA1217
Gene descriptionⁱ Full gene name according to HGNC.	KIAA1217
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KIAA1217 is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 1
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GRIK3	Glutamate ionotropic receptor kainate type subunit 3	0.8658	8
ROBO2	Roundabout guidance receptor 2	0.8541	8
SMIM17	Small integral membrane protein 17	0.8254	8
VWC2L	Von Willebrand factor C domain containing 2 like	0.8201	8
QRFPR	Pyroglutamylated RFamide peptide receptor	0.8134	8
TMEM178A	Transmembrane protein 178A	0.7908	21
PCDH11X	Protocadherin 11 X-linked	0.7902	8
PCLO	Piccolo presynaptic cytomatrix protein	0.7902	8
FAM189A1	Family with sequence similarity 189 member A1	0.7782	8
EPHA7	EPH receptor A7	0.7713	8
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.7658	8
SYT3	Synaptotagmin 3	0.7581	8
PCDH11Y	Protocadherin 11 Y-linked	0.7580	8
GRM8	Glutamate metabotropic receptor 8	0.7569	8
MYRIP	Myosin VIIA and Rab interacting protein	0.7496	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	149.7 nTPM
Adipose tissue	192.4 nTPM
Breast	106.9 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	34.4 nTPM
Lung	34.4 nTPM

Astrocytes	27.4 nTPM
Brain	27.4 nTPM

B-cells	1.0 nTPM
Breast	4.0 nTPM
Liver	2.8 nTPM
Adipose tissue	2.0 nTPM
Colon	1.6 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Basal squamous epithelial cells	145.1 nTPM
Esophagus	145.1 nTPM

Dendritic cells	0.4 nTPM
Breast	1.1 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	34.4 nTPM
Heart muscle	119.1 nTPM
Skeletal muscle	85.6 nTPM
Breast	61.8 nTPM
Lung	37.4 nTPM
Endometrium	35.4 nTPM
Ovary	35.3 nTPM
Esophagus	32.9 nTPM
Skin	19.0 nTPM
Prostate	16.8 nTPM
Pancreas	11.6 nTPM
Placenta	10.2 nTPM
Liver	7.3 nTPM
Testis	5.4 nTPM
Eye	4.1 nTPM

Fibroblasts	23.3 nTPM
Lung	48.0 nTPM
Breast	37.1 nTPM
Skeletal muscle	29.3 nTPM
Adipose tissue	28.3 nTPM
Stomach	28.2 nTPM
Skin	23.6 nTPM
Heart muscle	18.2 nTPM
Esophagus	16.5 nTPM
Prostate	14.1 nTPM
Ovary	8.2 nTPM
Placenta	4.6 nTPM

Intestinal goblet cells	22.8 nTPM
Rectum	29.4 nTPM
Small intestine	19.7 nTPM
Colon	19.3 nTPM

Macrophages	1.3 nTPM
Lung	4.1 nTPM
Endometrium	4.1 nTPM
Skeletal muscle	3.0 nTPM
Kidney	2.3 nTPM
Prostate	2.2 nTPM
Breast	1.9 nTPM
Esophagus	1.6 nTPM
Adipose tissue	0.3 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	22.7 nTPM
Colon	36.2 nTPM
Rectum	24.4 nTPM
Small intestine	7.5 nTPM

Plasma cells	3.1 nTPM
Esophagus	12.3 nTPM
Stomach	1.5 nTPM
Adipose tissue	1.3 nTPM
Spleen	0.6 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	36.9 nTPM
Bronchus	38.7 nTPM
Lung	35.0 nTPM

Smooth muscle cells	20.4 nTPM
Esophagus	38.8 nTPM
Adipose tissue	31.7 nTPM
Heart muscle	29.8 nTPM
Skin	25.8 nTPM
Breast	20.5 nTPM
Skeletal muscle	20.2 nTPM
Bronchus	17.2 nTPM
Endometrium	13.8 nTPM
Prostate	13.1 nTPM
Ovary	8.9 nTPM
Pancreas	5.3 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Cytotrophoblasts	50.2 nTPM
Placenta	50.2 nTPM

T-cells	2.2 nTPM
Endometrium	8.8 nTPM
Esophagus	6.6 nTPM
Skin	6.0 nTPM
Lung	3.0 nTPM
Breast	2.6 nTPM
Colon	2.4 nTPM
Ovary	2.2 nTPM
Liver	1.1 nTPM
Lymph node	0.9 nTPM
Adipose tissue	0.8 nTPM
Kidney	0.7 nTPM
Stomach	0.7 nTPM
Skeletal muscle	0.5 nTPM
Bone marrow	0.3 nTPM
Spleen	0.3 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM

Undifferentiated cells	19.4 nTPM
Rectum	25.0 nTPM
Colon	21.0 nTPM
Small intestine	12.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC