Single cell type - ZMYM2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZMYM2
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger MYM-type containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZMYM2 is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DHX57	DExH-box helicase 57	0.6024	25
CCNY	Cyclin Y	0.5785	25
FANCM	FA complementation group M	0.5514	25
LPIN1	Lipin 1	0.5493	25
AZIN2	Antizyme inhibitor 2	0.5481	25
SLC25A28	Solute carrier family 25 member 28	0.5467	25
HABP4	Hyaluronan binding protein 4	0.5447	25
ALMS1	ALMS1 centrosome and basal body associated protein	0.5340	25
RNF38	Ring finger protein 38	0.5269	25
HIP1	Huntingtin interacting protein 1	0.5268	25
CSNK1G2	Casein kinase 1 gamma 2	0.5244	25
FAM163A	Family with sequence similarity 163 member A	0.5203	25
USP34	Ubiquitin specific peptidase 34	0.5197	52
ANKRD53	Ankyrin repeat domain 53	0.5179	25
ST7L	Suppression of tumorigenicity 7 like	0.5114	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.1 nTPM
Adipose tissue	46.5 nTPM
Breast	33.7 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	39.3 nTPM
Lung	39.3 nTPM

Astrocytes	140.7 nTPM
Brain	140.7 nTPM

B-cells	85.3 nTPM
Adipose tissue	161.9 nTPM
Colon	124.6 nTPM
Stomach	99.0 nTPM
Lymph node	98.2 nTPM
Bone marrow	83.4 nTPM
Spleen	81.6 nTPM
Breast	70.9 nTPM
Kidney	57.1 nTPM
PBMC	49.9 nTPM
Liver	26.3 nTPM

Dendritic cells	71.2 nTPM
PBMC	99.6 nTPM
Adipose tissue	68.9 nTPM
Breast	45.2 nTPM

Endothelial cells	38.5 nTPM
Endometrium	54.2 nTPM
Heart muscle	51.2 nTPM
Ovary	47.5 nTPM
Eye	46.9 nTPM
Prostate	45.5 nTPM
Skin	41.3 nTPM
Skeletal muscle	40.4 nTPM
Testis	38.2 nTPM
Breast	32.6 nTPM
Esophagus	32.5 nTPM
Lung	31.2 nTPM
Liver	30.2 nTPM
Placenta	27.3 nTPM
Pancreas	19.3 nTPM

Fibroblasts	43.0 nTPM
Prostate	68.8 nTPM
Skin	54.3 nTPM
Stomach	44.6 nTPM
Heart muscle	42.0 nTPM
Breast	41.9 nTPM
Ovary	40.2 nTPM
Skeletal muscle	38.6 nTPM
Adipose tissue	38.4 nTPM
Esophagus	36.1 nTPM
Placenta	36.0 nTPM
Lung	32.4 nTPM

Intestinal goblet cells	28.4 nTPM
Rectum	36.2 nTPM
Colon	25.0 nTPM
Small intestine	24.1 nTPM

Macrophages	53.6 nTPM
Adipose tissue	94.9 nTPM
Spleen	83.9 nTPM
Bone marrow	74.9 nTPM
Breast	67.9 nTPM
Prostate	67.6 nTPM
Skeletal muscle	66.2 nTPM
Ovary	62.5 nTPM
Testis	51.2 nTPM
Esophagus	50.4 nTPM
Endometrium	45.8 nTPM
Stomach	41.0 nTPM
Lung	40.1 nTPM
Kidney	33.3 nTPM
PBMC	13.6 nTPM
Pancreas	10.2 nTPM

Paneth cells	41.4 nTPM
Colon	56.0 nTPM
Rectum	34.4 nTPM
Small intestine	33.8 nTPM

Plasma cells	42.1 nTPM
Adipose tissue	81.9 nTPM
Esophagus	49.4 nTPM
Stomach	34.8 nTPM
Bone marrow	23.0 nTPM
Spleen	21.4 nTPM

Respiratory ciliated cells	51.7 nTPM
Bronchus	63.9 nTPM
Lung	39.4 nTPM

Smooth muscle cells	38.3 nTPM
Skin	58.9 nTPM
Adipose tissue	56.6 nTPM
Ovary	54.3 nTPM
Endometrium	49.0 nTPM
Heart muscle	43.3 nTPM
Skeletal muscle	36.6 nTPM
Prostate	34.4 nTPM
Breast	32.2 nTPM
Esophagus	20.1 nTPM
Bronchus	18.9 nTPM
Pancreas	17.6 nTPM

T-cells	68.0 nTPM
Skin	119.7 nTPM
Breast	96.1 nTPM
Lymph node	93.7 nTPM
Colon	84.6 nTPM
Adipose tissue	84.5 nTPM
Prostate	71.1 nTPM
PBMC	70.8 nTPM
Endometrium	64.2 nTPM
Skeletal muscle	64.2 nTPM
Spleen	60.9 nTPM
Stomach	59.6 nTPM
Bone marrow	57.5 nTPM
Liver	53.0 nTPM
Kidney	49.3 nTPM
Ovary	48.9 nTPM
Esophagus	39.3 nTPM
Lung	38.0 nTPM

Basal keratinocytes	55.1 nTPM
Skin	55.1 nTPM

Basal prostatic cells	47.1 nTPM
Prostate	47.1 nTPM

Basal respiratory cells	51.4 nTPM
Bronchus	51.4 nTPM

Basal squamous epithelial cells	55.2 nTPM
Esophagus	55.2 nTPM

Undifferentiated cells	29.6 nTPM
Rectum	32.9 nTPM
Colon	28.6 nTPM
Small intestine	27.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC