Single cell type - PFDN5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PFDN5
Gene descriptionⁱ Full gene name according to HGNC.	Prefoldin subunit 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PFDN5 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EEF1D	Eukaryotic translation elongation factor 1 delta	0.6860	32
RPL32	Ribosomal protein L32	0.6767	32
RPS15	Ribosomal protein S15	0.6568	32
RPL34	Ribosomal protein L34	0.6510	32
RPL10	Ribosomal protein L10	0.6419	32
COMMD6	COMM domain containing 6	0.6310	32
RPL13	Ribosomal protein L13	0.6171	32
RPL38	Ribosomal protein L38	0.6134	32
RPS27	Ribosomal protein S27	0.6111	32
ZNF581	Zinc finger protein 581	0.6105	32
RPS9	Ribosomal protein S9	0.6079	32
RPL21	Ribosomal protein L21	0.6074	32
RPL12	Ribosomal protein L12	0.6039	32
RPL11	Ribosomal protein L11	0.6031	32
RPS27A	Ribosomal protein S27a	0.6027	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	711.6 nTPM
Breast	920.3 nTPM
Adipose tissue	502.9 nTPM

Alveolar cells type 1	262.8 nTPM
Lung	262.8 nTPM

Alveolar cells type 2	501.5 nTPM
Lung	501.5 nTPM

Astrocytes	27.7 nTPM
Brain	27.7 nTPM

B-cells	1274.1 nTPM
Kidney	1985.3 nTPM
PBMC	1835.9 nTPM
Adipose tissue	1526.8 nTPM
Lymph node	1243.4 nTPM
Spleen	1209.6 nTPM
Stomach	1147.2 nTPM
Breast	1115.4 nTPM
Bone marrow	988.4 nTPM
Liver	874.3 nTPM
Colon	814.7 nTPM

Basal squamous epithelial cells	900.3 nTPM
Esophagus	900.3 nTPM

Dendritic cells	862.2 nTPM
Breast	992.5 nTPM
PBMC	805.0 nTPM
Adipose tissue	789.3 nTPM

Endothelial cells	734.7 nTPM
Skin	1707.6 nTPM
Breast	1045.0 nTPM
Liver	1035.5 nTPM
Testis	978.4 nTPM
Prostate	965.3 nTPM
Placenta	768.5 nTPM
Esophagus	635.5 nTPM
Skeletal muscle	550.3 nTPM
Ovary	499.8 nTPM
Heart muscle	493.2 nTPM
Eye	475.8 nTPM
Pancreas	401.5 nTPM
Lung	380.5 nTPM
Endometrium	348.4 nTPM

Enteroendocrine cells	659.9 nTPM
Rectum	715.9 nTPM
Colon	604.0 nTPM

Erythroid cells	587.9 nTPM
Liver	764.7 nTPM
Bone marrow	411.1 nTPM

Fibroblasts	708.4 nTPM
Skin	1439.0 nTPM
Placenta	964.0 nTPM
Breast	936.4 nTPM
Prostate	691.0 nTPM
Ovary	628.1 nTPM
Adipose tissue	616.4 nTPM
Heart muscle	593.8 nTPM
Esophagus	561.2 nTPM
Lung	555.1 nTPM
Stomach	439.5 nTPM
Skeletal muscle	368.3 nTPM

Intestinal goblet cells	892.0 nTPM
Colon	1094.2 nTPM
Rectum	911.4 nTPM
Small intestine	670.5 nTPM

Macrophages	1235.9 nTPM
Kidney	2635.6 nTPM
Ovary	1855.9 nTPM
Adipose tissue	1608.5 nTPM
Spleen	1379.0 nTPM
Prostate	1333.2 nTPM
Stomach	1265.8 nTPM
Testis	1249.0 nTPM
Breast	1146.9 nTPM
Bone marrow	1108.3 nTPM
Skeletal muscle	1087.8 nTPM
Pancreas	1023.5 nTPM
Lung	885.3 nTPM
Endometrium	875.4 nTPM
Esophagus	838.7 nTPM
PBMC	245.5 nTPM

Paneth cells	990.6 nTPM
Small intestine	1073.7 nTPM
Colon	1060.6 nTPM
Rectum	837.3 nTPM

Plasma cells	582.9 nTPM
Stomach	774.0 nTPM
Esophagus	720.5 nTPM
Adipose tissue	563.9 nTPM
Spleen	476.9 nTPM
Bone marrow	379.0 nTPM

Cholangiocytes	684.9 nTPM
Liver	684.9 nTPM

Collecting duct cells	566.4 nTPM
Kidney	566.4 nTPM

Cone photoreceptor cells	102.2 nTPM
Eye	102.2 nTPM

Cytotrophoblasts	899.8 nTPM
Placenta	899.8 nTPM

Respiratory ciliated cells	862.7 nTPM
Bronchus	1068.0 nTPM
Lung	657.4 nTPM

Smooth muscle cells	902.4 nTPM
Skin	1693.9 nTPM
Breast	1297.2 nTPM
Prostate	1075.3 nTPM
Bronchus	883.9 nTPM
Heart muscle	877.7 nTPM
Ovary	849.5 nTPM
Adipose tissue	816.3 nTPM
Esophagus	669.8 nTPM
Skeletal muscle	650.6 nTPM
Pancreas	588.6 nTPM
Endometrium	523.7 nTPM

T-cells	1147.0 nTPM
Skin	2556.6 nTPM
PBMC	1930.9 nTPM
Kidney	1681.8 nTPM
Adipose tissue	1282.5 nTPM
Lymph node	1267.0 nTPM
Breast	1214.8 nTPM
Liver	1168.9 nTPM
Prostate	1107.7 nTPM
Spleen	1084.2 nTPM
Skeletal muscle	910.3 nTPM
Stomach	906.9 nTPM
Ovary	885.3 nTPM
Bone marrow	814.3 nTPM
Lung	733.5 nTPM
Esophagus	707.4 nTPM
Colon	688.5 nTPM
Endometrium	558.5 nTPM

Undifferentiated cells	849.4 nTPM
Colon	880.8 nTPM
Small intestine	845.5 nTPM
Rectum	822.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC