Single cell type - LPGAT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LPGAT1
Gene descriptionⁱ Full gene name according to HGNC.	Lysophosphatidylglycerol acyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LPGAT1 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
APPBP2	Amyloid beta precursor protein binding protein 2	0.6204	29
PIBF1	Progesterone immunomodulatory binding factor 1	0.5780	29
USP46	Ubiquitin specific peptidase 46	0.5707	29
NDRG3	NDRG family member 3	0.5446	29
FAM200A	Family with sequence similarity 200 member A	0.5438	29
AGAP5	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	0.5438	29
AGAP4	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	0.5327	29
TP53TG5	TP53 target 5	0.5308	29
WRN	WRN RecQ like helicase	0.5276	29
POLK	DNA polymerase kappa	0.5255	23
ARID2	AT-rich interaction domain 2	0.5250	29
TTYH2	Tweety family member 2	0.5218	42
NSUN3	NOP2/Sun RNA methyltransferase 3	0.5185	29
SENP2	SUMO specific peptidase 2	0.5156	29
ZNF790	Zinc finger protein 790	0.5117	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.0 nTPM
Adipose tissue	54.0 nTPM
Breast	46.0 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	21.0 nTPM
Lung	21.0 nTPM

Astrocytes	28.7 nTPM
Brain	28.7 nTPM

B-cells	42.2 nTPM
Adipose tissue	68.6 nTPM
Bone marrow	67.0 nTPM
Stomach	61.7 nTPM
Spleen	52.6 nTPM
Lymph node	52.4 nTPM
PBMC	37.1 nTPM
Colon	31.9 nTPM
Breast	28.1 nTPM
Kidney	14.3 nTPM
Liver	8.1 nTPM

Dendritic cells	73.2 nTPM
PBMC	83.7 nTPM
Adipose tissue	79.2 nTPM
Breast	56.5 nTPM

Endothelial cells	31.6 nTPM
Eye	54.2 nTPM
Skeletal muscle	47.9 nTPM
Prostate	42.5 nTPM
Ovary	39.7 nTPM
Endometrium	39.3 nTPM
Esophagus	39.2 nTPM
Heart muscle	34.9 nTPM
Testis	31.7 nTPM
Lung	28.1 nTPM
Breast	27.3 nTPM
Skin	24.1 nTPM
Liver	22.0 nTPM
Placenta	10.8 nTPM
Pancreas	0.0 nTPM

Fibroblasts	30.9 nTPM
Ovary	73.9 nTPM
Heart muscle	56.5 nTPM
Prostate	30.2 nTPM
Stomach	29.7 nTPM
Adipose tissue	28.0 nTPM
Skeletal muscle	27.3 nTPM
Esophagus	22.3 nTPM
Breast	21.1 nTPM
Skin	17.5 nTPM
Placenta	17.4 nTPM
Lung	15.7 nTPM

Intestinal goblet cells	14.6 nTPM
Small intestine	16.9 nTPM
Rectum	14.8 nTPM
Colon	12.1 nTPM

Macrophages	44.9 nTPM
Spleen	80.9 nTPM
Skeletal muscle	75.1 nTPM
Adipose tissue	69.7 nTPM
Bone marrow	63.7 nTPM
Stomach	55.7 nTPM
Endometrium	45.5 nTPM
Breast	43.4 nTPM
Esophagus	42.5 nTPM
Testis	40.1 nTPM
Ovary	40.0 nTPM
Kidney	37.8 nTPM
Prostate	31.0 nTPM
Lung	25.3 nTPM
Pancreas	23.0 nTPM
PBMC	0.0 nTPM

Paneth cells	19.5 nTPM
Small intestine	30.0 nTPM
Rectum	18.6 nTPM
Colon	9.9 nTPM

Plasma cells	15.0 nTPM
Adipose tissue	38.8 nTPM
Spleen	15.7 nTPM
Bone marrow	8.2 nTPM
Stomach	6.4 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	38.2 nTPM
Lung	40.8 nTPM
Bronchus	35.7 nTPM

Smooth muscle cells	33.2 nTPM
Heart muscle	78.2 nTPM
Ovary	42.3 nTPM
Prostate	40.7 nTPM
Endometrium	37.4 nTPM
Adipose tissue	33.0 nTPM
Breast	31.3 nTPM
Skeletal muscle	31.2 nTPM
Pancreas	22.2 nTPM
Esophagus	20.1 nTPM
Skin	16.8 nTPM
Bronchus	12.3 nTPM

T-cells	32.5 nTPM
Skeletal muscle	57.7 nTPM
Ovary	51.2 nTPM
Adipose tissue	46.8 nTPM
Esophagus	45.9 nTPM
Bone marrow	42.9 nTPM
Endometrium	41.0 nTPM
Stomach	38.7 nTPM
Spleen	37.7 nTPM
Breast	34.1 nTPM
Prostate	28.4 nTPM
Liver	23.8 nTPM
Lymph node	22.6 nTPM
PBMC	18.8 nTPM
Lung	18.2 nTPM
Kidney	17.8 nTPM
Colon	14.2 nTPM
Skin	13.3 nTPM

Basal keratinocytes	12.2 nTPM
Skin	12.2 nTPM

Basal prostatic cells	77.7 nTPM
Prostate	77.7 nTPM

Basal respiratory cells	11.5 nTPM
Bronchus	11.5 nTPM

Basal squamous epithelial cells	38.1 nTPM
Esophagus	38.1 nTPM

Undifferentiated cells	23.4 nTPM
Colon	27.1 nTPM
Small intestine	23.5 nTPM
Rectum	19.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC