Single cell type - PLA2G12A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLA2G12A
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipase A2 group XIIA
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLA2G12A is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FNTB	Farnesyltransferase, CAAX box, beta	0.8066	51
TNFSF4	TNF superfamily member 4	0.7692	51
GP1BA	Glycoprotein Ib platelet subunit alpha	0.6752	51
SLC35D3	Solute carrier family 35 member D3	0.6742	51
TUBB1	Tubulin beta 1 class VI	0.6729	51
PF4	Platelet factor 4	0.6726	51
HBG1	Hemoglobin subunit gamma 1	0.6725	51
TREML1	Triggering receptor expressed on myeloid cells like 1	0.6719	51
LY6G6F	Lymphocyte antigen 6 family member G6F	0.6695	51
PPBP	Pro-platelet basic protein	0.6686	51
GP9	Glycoprotein IX platelet	0.6685	51
ALOX12	Arachidonate 12-lipoxygenase, 12S type	0.6665	51
SCGB1C1	Secretoglobin family 1C member 1	0.6611	51
DCLRE1A	DNA cross-link repair 1A	0.6590	51
RGS18	Regulator of G protein signaling 18	0.6566	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Adipose tissue	12.4 nTPM
Breast	11.1 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	21.8 nTPM
Lung	21.8 nTPM

Astrocytes	14.4 nTPM
Brain	14.4 nTPM

B-cells	11.7 nTPM
Liver	29.4 nTPM
Colon	17.6 nTPM
Spleen	13.9 nTPM
Stomach	10.5 nTPM
Lymph node	10.3 nTPM
PBMC	9.9 nTPM
Bone marrow	9.8 nTPM
Breast	9.4 nTPM
Adipose tissue	6.0 nTPM
Kidney	0.0 nTPM

Dendritic cells	8.3 nTPM
PBMC	12.0 nTPM
Breast	6.9 nTPM
Adipose tissue	5.9 nTPM

Endothelial cells	17.1 nTPM
Liver	44.9 nTPM
Eye	26.7 nTPM
Testis	25.8 nTPM
Skin	18.4 nTPM
Skeletal muscle	18.0 nTPM
Esophagus	18.0 nTPM
Heart muscle	14.7 nTPM
Prostate	14.6 nTPM
Breast	14.1 nTPM
Placenta	13.7 nTPM
Ovary	11.8 nTPM
Endometrium	11.3 nTPM
Pancreas	7.7 nTPM
Lung	0.0 nTPM

Enteroendocrine cells	107.7 nTPM
Colon	120.8 nTPM
Rectum	94.7 nTPM

Fibroblasts	29.3 nTPM
Lung	60.3 nTPM
Heart muscle	44.1 nTPM
Esophagus	34.6 nTPM
Skeletal muscle	33.6 nTPM
Placenta	28.6 nTPM
Ovary	23.8 nTPM
Skin	23.2 nTPM
Stomach	22.3 nTPM
Adipose tissue	18.4 nTPM
Breast	17.3 nTPM
Prostate	16.3 nTPM

Intestinal goblet cells	52.8 nTPM
Rectum	66.5 nTPM
Small intestine	59.6 nTPM
Colon	32.2 nTPM

Macrophages	64.6 nTPM
PBMC	845.7 nTPM
Prostate	29.8 nTPM
Esophagus	14.2 nTPM
Spleen	12.5 nTPM
Skeletal muscle	12.0 nTPM
Testis	11.7 nTPM
Ovary	8.8 nTPM
Pancreas	7.7 nTPM
Breast	5.4 nTPM
Lung	5.0 nTPM
Kidney	4.6 nTPM
Adipose tissue	4.5 nTPM
Bone marrow	3.7 nTPM
Endometrium	3.0 nTPM
Stomach	0.0 nTPM

Paneth cells	38.9 nTPM
Rectum	62.5 nTPM
Small intestine	37.6 nTPM
Colon	16.5 nTPM

Plasma cells	20.6 nTPM
Spleen	31.8 nTPM
Stomach	25.3 nTPM
Esophagus	24.6 nTPM
Bone marrow	14.8 nTPM
Adipose tissue	6.4 nTPM

Respiratory ciliated cells	16.4 nTPM
Bronchus	21.1 nTPM
Lung	11.7 nTPM

Smooth muscle cells	21.1 nTPM
Heart muscle	45.6 nTPM
Esophagus	27.9 nTPM
Skeletal muscle	26.5 nTPM
Ovary	22.8 nTPM
Skin	22.0 nTPM
Prostate	21.6 nTPM
Adipose tissue	19.1 nTPM
Breast	16.4 nTPM
Pancreas	12.1 nTPM
Endometrium	9.4 nTPM
Bronchus	8.4 nTPM

Basal keratinocytes	36.7 nTPM
Skin	36.7 nTPM

Basal prostatic cells	36.3 nTPM
Prostate	36.3 nTPM

Basal respiratory cells	39.7 nTPM
Bronchus	39.7 nTPM

Basal squamous epithelial cells	25.0 nTPM
Esophagus	25.0 nTPM

T-cells	14.3 nTPM
PBMC	32.4 nTPM
Esophagus	26.2 nTPM
Prostate	23.6 nTPM
Skeletal muscle	17.9 nTPM
Lymph node	17.5 nTPM
Spleen	16.5 nTPM
Liver	16.4 nTPM
Bone marrow	14.0 nTPM
Skin	13.3 nTPM
Colon	12.8 nTPM
Stomach	10.8 nTPM
Breast	10.2 nTPM
Kidney	8.2 nTPM
Endometrium	7.8 nTPM
Adipose tissue	6.5 nTPM
Lung	6.1 nTPM
Ovary	2.2 nTPM

Undifferentiated cells	58.9 nTPM
Rectum	76.1 nTPM
Small intestine	62.5 nTPM
Colon	38.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC