Single cell type - ATP8A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP8A1
Gene descriptionⁱ Full gene name according to HGNC.	ATPase phospholipid transporting 8A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AN3-CA, Daudi, HEL, REH, SH-SY5Y)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP8A1 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MVB12B	Multivesicular body subunit 12B	0.7813	42
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.7776	42
HS3ST5	Heparan sulfate-glucosamine 3-sulfotransferase 5	0.7717	42
DPYD	Dihydropyrimidine dehydrogenase	0.7666	42
OTUD7A	OTU deubiquitinase 7A	0.7504	42
MAN2A1	Mannosidase alpha class 2A member 1	0.7471	42
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.7461	42
SLC5A11	Solute carrier family 5 member 11	0.7447	42
PEX5L	Peroxisomal biogenesis factor 5 like	0.7433	42
MAP6D1	MAP6 domain containing 1	0.7365	42
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.7356	42
ABCA2	ATP binding cassette subfamily A member 2	0.7317	42
TRIM59	Tripartite motif containing 59	0.7289	42
ST18	ST18 C2H2C-type zinc finger transcription factor	0.7286	42
ERMN	Ermin	0.7277	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.1 nTPM
Adipose tissue	29.1 nTPM
Breast	23.1 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	80.1 nTPM
Lung	80.1 nTPM

Astrocytes	136.1 nTPM
Brain	136.1 nTPM

B-cells	23.3 nTPM
Bone marrow	42.5 nTPM
Stomach	39.1 nTPM
Spleen	36.4 nTPM
Lymph node	30.1 nTPM
Adipose tissue	22.1 nTPM
PBMC	20.0 nTPM
Colon	16.0 nTPM
Breast	13.4 nTPM
Liver	9.0 nTPM
Kidney	4.8 nTPM

Dendritic cells	52.9 nTPM
Adipose tissue	71.3 nTPM
PBMC	55.8 nTPM
Breast	31.7 nTPM

Endothelial cells	13.6 nTPM
Heart muscle	38.0 nTPM
Esophagus	24.4 nTPM
Skeletal muscle	22.2 nTPM
Breast	18.7 nTPM
Endometrium	15.4 nTPM
Skin	13.8 nTPM
Lung	12.5 nTPM
Eye	11.3 nTPM
Testis	10.1 nTPM
Ovary	6.8 nTPM
Placenta	6.2 nTPM
Prostate	4.8 nTPM
Pancreas	3.9 nTPM
Liver	2.7 nTPM

Fibroblasts	4.8 nTPM
Stomach	13.4 nTPM
Lung	7.8 nTPM
Esophagus	7.4 nTPM
Heart muscle	7.0 nTPM
Skeletal muscle	3.7 nTPM
Ovary	3.7 nTPM
Skin	3.6 nTPM
Adipose tissue	2.5 nTPM
Prostate	1.5 nTPM
Breast	1.3 nTPM
Placenta	0.4 nTPM

Intestinal goblet cells	28.6 nTPM
Small intestine	31.8 nTPM
Rectum	29.9 nTPM
Colon	24.3 nTPM

Macrophages	8.9 nTPM
Ovary	21.4 nTPM
Stomach	17.6 nTPM
Bone marrow	13.8 nTPM
Spleen	13.5 nTPM
Adipose tissue	10.4 nTPM
Skeletal muscle	9.8 nTPM
Breast	9.4 nTPM
Kidney	9.1 nTPM
Testis	6.9 nTPM
Lung	5.4 nTPM
Endometrium	5.4 nTPM
Esophagus	4.8 nTPM
Prostate	3.4 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	10.2 nTPM
Rectum	19.9 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	37.6 nTPM
Adipose tissue	76.2 nTPM
Stomach	42.8 nTPM
Spleen	30.2 nTPM
Bone marrow	26.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	0.3 nTPM
Bronchus	0.7 nTPM
Lung	0.0 nTPM

Smooth muscle cells	2.7 nTPM
Ovary	9.1 nTPM
Heart muscle	8.0 nTPM
Esophagus	4.6 nTPM
Breast	2.4 nTPM
Skin	2.1 nTPM
Endometrium	1.7 nTPM
Adipose tissue	0.7 nTPM
Prostate	0.4 nTPM
Skeletal muscle	0.3 nTPM
Pancreas	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	51.6 nTPM
Stomach	176.4 nTPM
Spleen	101.0 nTPM
Lymph node	79.2 nTPM
Bone marrow	76.8 nTPM
Colon	60.8 nTPM
Esophagus	58.9 nTPM
Adipose tissue	54.5 nTPM
Skeletal muscle	42.0 nTPM
Endometrium	38.4 nTPM
Breast	38.2 nTPM
Ovary	33.3 nTPM
Liver	31.2 nTPM
Prostate	23.6 nTPM
PBMC	21.6 nTPM
Kidney	17.8 nTPM
Lung	12.2 nTPM
Skin	11.9 nTPM

Basal prostatic cells	1.8 nTPM
Prostate	1.8 nTPM

Basal respiratory cells	0.6 nTPM
Bronchus	0.6 nTPM

Basal squamous epithelial cells	2.2 nTPM
Esophagus	2.2 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Undifferentiated cells	25.0 nTPM
Rectum	28.7 nTPM
Colon	24.5 nTPM
Small intestine	22.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC