Single cell type - SNRPC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNRPC
Gene descriptionⁱ Full gene name according to HGNC.	Small nuclear ribonucleoprotein polypeptide C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNRPC is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TIMM23	Translocase of inner mitochondrial membrane 23	0.6702	66
C16orf95	Chromosome 16 open reading frame 95	0.6147	66
RANBP3	RAN binding protein 3	0.6003	66
SPRYD7	SPRY domain containing 7	0.5926	66
FBXO25	F-box protein 25	0.5807	66
CSTF1	Cleavage stimulation factor subunit 1	0.5783	66
GJA8	Gap junction protein alpha 8	0.5777	66
SLC25A2	Solute carrier family 25 member 2	0.5760	66
FAM170A	Family with sequence similarity 170 member A	0.5721	66
ZC2HC1C	Zinc finger C2HC-type containing 1C	0.5696	66
PCDHB8	Protocadherin beta 8	0.5646	66
RNF20	Ring finger protein 20	0.5629	66
PRKACG	Protein kinase cAMP-activated catalytic subunit gamma	0.5627	66
CCDC42	Coiled-coil domain containing 42	0.5579	66
CETN1	Centrin 1	0.5537	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.6 nTPM
Breast	46.4 nTPM
Adipose tissue	40.9 nTPM

Alveolar cells type 1	121.8 nTPM
Lung	121.8 nTPM

Alveolar cells type 2	107.9 nTPM
Lung	107.9 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	70.5 nTPM
Liver	150.8 nTPM
PBMC	92.7 nTPM
Bone marrow	77.6 nTPM
Colon	67.1 nTPM
Kidney	66.6 nTPM
Spleen	64.7 nTPM
Stomach	63.6 nTPM
Lymph node	48.5 nTPM
Adipose tissue	43.7 nTPM
Breast	29.4 nTPM

Dendritic cells	69.0 nTPM
PBMC	79.7 nTPM
Adipose tissue	70.4 nTPM
Breast	56.9 nTPM

Endothelial cells	74.3 nTPM
Placenta	163.2 nTPM
Pancreas	115.9 nTPM
Heart muscle	108.5 nTPM
Lung	93.6 nTPM
Ovary	80.9 nTPM
Esophagus	63.7 nTPM
Testis	62.2 nTPM
Skin	61.3 nTPM
Endometrium	56.6 nTPM
Liver	49.5 nTPM
Skeletal muscle	49.4 nTPM
Prostate	48.4 nTPM
Breast	46.0 nTPM
Eye	41.2 nTPM

Enteroendocrine cells	90.7 nTPM
Rectum	106.8 nTPM
Colon	74.6 nTPM

Fibroblasts	72.3 nTPM
Placenta	175.8 nTPM
Heart muscle	109.0 nTPM
Lung	106.1 nTPM
Ovary	99.2 nTPM
Adipose tissue	52.5 nTPM
Esophagus	50.4 nTPM
Skin	45.0 nTPM
Stomach	44.6 nTPM
Breast	40.7 nTPM
Skeletal muscle	39.0 nTPM
Prostate	33.2 nTPM

Intestinal goblet cells	92.6 nTPM
Colon	109.3 nTPM
Rectum	92.1 nTPM
Small intestine	76.5 nTPM

Macrophages	75.4 nTPM
Pancreas	171.0 nTPM
Kidney	129.4 nTPM
Lung	119.2 nTPM
Testis	95.9 nTPM
Ovary	93.3 nTPM
Endometrium	69.7 nTPM
Bone marrow	68.7 nTPM
Prostate	67.6 nTPM
Esophagus	58.3 nTPM
Spleen	55.0 nTPM
Breast	54.2 nTPM
Adipose tissue	50.7 nTPM
Skeletal muscle	44.0 nTPM
Stomach	41.0 nTPM
PBMC	13.6 nTPM

Paneth cells	66.7 nTPM
Rectum	95.0 nTPM
Small intestine	78.9 nTPM
Colon	26.4 nTPM

Plasma cells	116.6 nTPM
Spleen	196.1 nTPM
Bone marrow	169.7 nTPM
Stomach	117.7 nTPM
Esophagus	61.7 nTPM
Adipose tissue	38.0 nTPM

Respiratory ciliated cells	127.4 nTPM
Lung	142.8 nTPM
Bronchus	111.9 nTPM

Smooth muscle cells	82.8 nTPM
Heart muscle	217.0 nTPM
Pancreas	212.4 nTPM
Ovary	82.2 nTPM
Skeletal muscle	63.8 nTPM
Skin	63.5 nTPM
Esophagus	49.6 nTPM
Bronchus	45.8 nTPM
Breast	45.2 nTPM
Prostate	44.4 nTPM
Endometrium	43.9 nTPM
Adipose tissue	43.7 nTPM

Basal prostatic cells	76.0 nTPM
Prostate	76.0 nTPM

Basal respiratory cells	178.6 nTPM
Bronchus	178.6 nTPM

Basal squamous epithelial cells	72.8 nTPM
Esophagus	72.8 nTPM

Cholangiocytes	82.9 nTPM
Liver	82.9 nTPM

T-cells	70.7 nTPM
Lung	120.0 nTPM
Liver	101.2 nTPM
PBMC	99.2 nTPM
Kidney	98.5 nTPM
Stomach	82.3 nTPM
Bone marrow	73.5 nTPM
Colon	70.3 nTPM
Spleen	67.0 nTPM
Lymph node	66.3 nTPM
Skin	64.9 nTPM
Ovary	64.5 nTPM
Endometrium	57.2 nTPM
Prostate	56.8 nTPM
Adipose tissue	55.1 nTPM
Skeletal muscle	47.5 nTPM
Breast	44.8 nTPM
Esophagus	32.8 nTPM

Undifferentiated cells	109.6 nTPM
Colon	111.5 nTPM
Small intestine	110.6 nTPM
Rectum	106.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC