Expression of MT2A in glioma - The Human Protein Atlas

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

MT2A is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 313.35

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

3-year survival highⁱ N/A

3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

505.4

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	2713.3
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	2375.9
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	2353.1
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	2147.1
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	2008.3
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	1577.4
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	1446.7
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	1361.1
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	1309.4
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	1282.3
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	1210.5
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	1173.7
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	1131.5
TCGA-14-1034-01A	60 years, female, dead, 485 days	1084.8
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	1084.5
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	1062.4
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	971.8
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	964.0
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	960.9
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	946.8
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	940.2
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	921.8
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	861.0
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	847.0
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	821.6
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	818.1
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	768.1
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	766.0
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	763.9
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	731.7
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	725.7
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	721.7
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	703.3
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	695.3
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	691.7
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	686.2
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	683.8
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	679.4
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	610.4
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	600.1
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	599.6
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	599.3
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	592.1
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	564.7
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	564.2
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	557.1
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	555.5
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	527.2
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	517.7
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	516.9
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	486.2
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	483.6
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	481.8
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	467.8
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	460.5
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	460.4
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	460.3
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	451.1
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	449.9
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	447.5
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	447.1
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	446.2
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	432.4
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	430.2
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	426.9
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	422.5
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	409.8
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	409.4
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	395.5
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	392.4
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	391.6
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	388.3
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	386.7
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	385.7
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	364.4
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	363.2
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	354.1
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	351.3
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	350.9
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	337.5
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	334.8
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	333.3
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	323.8
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	320.4
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	314.1
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	312.6
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	311.8
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	310.3
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	303.9
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	300.9
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	286.3
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	285.8
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	283.8
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	264.9
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	264.8
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	260.2
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	259.0
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	258.9
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	255.8
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	254.8
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	253.3
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	250.4
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	249.6
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	246.1
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	244.6
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	242.4
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	238.2
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	238.2
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	236.8
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	235.8
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	228.4
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	219.9
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	216.3
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	215.9
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	209.5
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	209.1
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	208.7
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	204.8
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	201.0
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	200.6
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	198.4
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	196.6
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	196.5
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	194.2
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	193.2
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	188.9
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	184.4
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	176.3
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	174.4
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	170.6
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	170.3
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	166.7
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	159.3
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	158.1
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	147.8
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	146.4
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	145.3
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	142.6
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	140.0
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	135.0
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	131.4
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	128.6
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	117.7
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	115.4
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	111.4
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	101.6
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	99.1
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	98.2
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	80.1
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	79.1
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	74.8
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	49.0
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	32.4
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GLIOMA - Protein expressionⁱ

Pending cancer tissue analysis