Single cell type - PPDPF - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPDPF
Gene descriptionⁱ Full gene name according to HGNC.	Pancreatic progenitor cell differentiation and proliferation factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Proximal enterocytes, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Proximal enterocytes, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PPDPF is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAB25	RAB25, member RAS oncogene family	0.5547	61
CNFN	Cornifelin	0.5460	61
S100A14	S100 calcium binding protein A14	0.5132	61
CLDN8	Claudin 8	0.5078	53
CRABP2	Cellular retinoic acid binding protein 2	0.5064	61
FAM83F	Family with sequence similarity 83 member F	0.5061	25
ARF5	ADP ribosylation factor 5	0.5054	61
TMEM61	Transmembrane protein 61	0.5048	27
WNK4	WNK lysine deficient protein kinase 4	0.5040	39
SRARP	Steroid receptor associated and regulated protein	0.4850	39
TMEM134	Transmembrane protein 134	0.4818	16
COX6A1	Cytochrome c oxidase subunit 6A1	0.4758	39
PRR15L	Proline rich 15 like	0.4741	45
DSC2	Desmocollin 2	0.4740	61
HIGD1A	HIG1 hypoxia inducible domain family member 1A	0.4739	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	328.1 nTPM
Breast	417.5 nTPM
Adipose tissue	238.6 nTPM

Alveolar cells type 1	314.1 nTPM
Lung	314.1 nTPM

Alveolar cells type 2	220.3 nTPM
Lung	220.3 nTPM

Astrocytes	15.7 nTPM
Brain	15.7 nTPM

B-cells	462.8 nTPM
Adipose tissue	606.5 nTPM
PBMC	551.0 nTPM
Bone marrow	504.3 nTPM
Spleen	497.0 nTPM
Stomach	490.9 nTPM
Breast	448.0 nTPM
Kidney	447.5 nTPM
Lymph node	424.9 nTPM
Colon	396.2 nTPM
Liver	261.7 nTPM

Basal squamous epithelial cells	375.6 nTPM
Esophagus	375.6 nTPM

Dendritic cells	422.5 nTPM
Breast	516.5 nTPM
Adipose tissue	492.0 nTPM
PBMC	259.0 nTPM

Distal enterocytes	2528.3 nTPM
Rectum	3030.2 nTPM
Colon	2026.3 nTPM

Endothelial cells	294.2 nTPM
Skin	623.4 nTPM
Placenta	533.8 nTPM
Breast	529.2 nTPM
Esophagus	392.2 nTPM
Liver	379.7 nTPM
Prostate	273.1 nTPM
Pancreas	270.2 nTPM
Skeletal muscle	229.1 nTPM
Testis	219.2 nTPM
Endometrium	211.0 nTPM
Ovary	175.9 nTPM
Lung	131.0 nTPM
Eye	128.7 nTPM
Heart muscle	22.2 nTPM

Enteroendocrine cells	796.4 nTPM
Rectum	885.8 nTPM
Colon	707.1 nTPM

Erythroid cells	399.0 nTPM
Liver	518.8 nTPM
Bone marrow	279.1 nTPM

Fibroblasts	430.8 nTPM
Placenta	864.5 nTPM
Skin	619.3 nTPM
Esophagus	619.1 nTPM
Breast	601.4 nTPM
Adipose tissue	545.7 nTPM
Stomach	409.8 nTPM
Ovary	388.5 nTPM
Prostate	258.3 nTPM
Skeletal muscle	200.5 nTPM
Lung	200.0 nTPM
Heart muscle	31.2 nTPM

Intestinal goblet cells	1549.5 nTPM
Colon	1767.4 nTPM
Rectum	1739.9 nTPM
Small intestine	1141.3 nTPM

Macrophages	366.4 nTPM
PBMC	954.9 nTPM
Ovary	604.6 nTPM
Kidney	523.3 nTPM
Pancreas	423.6 nTPM
Adipose tissue	379.6 nTPM
Prostate	362.3 nTPM
Breast	340.5 nTPM
Spleen	321.4 nTPM
Testis	278.2 nTPM
Bone marrow	266.1 nTPM
Esophagus	262.8 nTPM
Endometrium	223.5 nTPM
Stomach	205.2 nTPM
Skeletal muscle	196.3 nTPM
Lung	154.0 nTPM

Paneth cells	2752.7 nTPM
Colon	3336.6 nTPM
Small intestine	3014.8 nTPM
Rectum	1906.6 nTPM

Cholangiocytes	906.5 nTPM
Liver	906.5 nTPM

Collecting duct cells	960.0 nTPM
Kidney	960.0 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Cytotrophoblasts	428.4 nTPM
Placenta	428.4 nTPM

Plasma cells	280.4 nTPM
Stomach	386.3 nTPM
Adipose tissue	338.7 nTPM
Esophagus	332.5 nTPM
Spleen	189.5 nTPM
Bone marrow	155.0 nTPM

Respiratory ciliated cells	542.0 nTPM
Bronchus	763.4 nTPM
Lung	320.7 nTPM

Smooth muscle cells	541.5 nTPM
Esophagus	1055.9 nTPM
Skin	868.6 nTPM
Pancreas	777.3 nTPM
Breast	655.9 nTPM
Prostate	610.2 nTPM
Adipose tissue	517.6 nTPM
Bronchus	422.3 nTPM
Skeletal muscle	380.5 nTPM
Ovary	361.9 nTPM
Endometrium	291.5 nTPM
Heart muscle	15.6 nTPM

T-cells	541.7 nTPM
Skin	1188.5 nTPM
Adipose tissue	709.1 nTPM
Breast	675.0 nTPM
Spleen	652.5 nTPM
Kidney	619.5 nTPM
Stomach	595.9 nTPM
PBMC	592.5 nTPM
Bone marrow	564.8 nTPM
Colon	535.0 nTPM
Lymph node	522.2 nTPM
Esophagus	517.5 nTPM
Liver	456.1 nTPM
Skeletal muscle	428.1 nTPM
Prostate	374.0 nTPM
Endometrium	325.5 nTPM
Ovary	264.7 nTPM
Lung	188.3 nTPM

Undifferentiated cells	1132.9 nTPM
Colon	1309.8 nTPM
Rectum	1239.6 nTPM
Small intestine	849.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC