Single cell type - PLAGL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLAGL2
Gene descriptionⁱ Full gene name according to HGNC.	PLAG1 like zinc finger 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids, Glandular and luminal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids, Glandular and luminal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLAGL2 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPM1G	Protein phosphatase, Mg2+/Mn2+ dependent 1G	0.6997	31
POLDIP3	DNA polymerase delta interacting protein 3	0.6797	31
ZNF628	Zinc finger protein 628	0.6696	31
CCHCR1	Coiled-coil alpha-helical rod protein 1	0.6691	44
LIG3	DNA ligase 3	0.6490	31
ATXN3L	Ataxin 3 like	0.6410	31
C11orf71	Chromosome 11 open reading frame 71	0.6397	31
HSPB9	Heat shock protein family B (small) member 9	0.6377	31
C16orf72	Chromosome 16 open reading frame 72	0.6315	31
ARL9	ADP ribosylation factor like GTPase 9	0.6291	31
SPZ1	Spermatogenic leucine zipper 1	0.6289	31
ARMS2	Age-related maculopathy susceptibility 2	0.6272	31
C9orf50	Chromosome 9 open reading frame 50	0.6265	31
ASB12	Ankyrin repeat and SOCS box containing 12	0.6215	31
CCDC70	Coiled-coil domain containing 70	0.6208	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.3 nTPM
Adipose tissue	6.2 nTPM
Breast	2.5 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	21.1 nTPM
Lung	21.1 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	6.0 nTPM
Adipose tissue	9.6 nTPM
Kidney	9.5 nTPM
Colon	8.0 nTPM
Spleen	7.6 nTPM
Stomach	6.8 nTPM
Liver	5.9 nTPM
Lymph node	4.2 nTPM
Bone marrow	3.2 nTPM
PBMC	2.8 nTPM
Breast	2.6 nTPM

Dendritic cells	8.1 nTPM
Adipose tissue	9.9 nTPM
PBMC	8.0 nTPM
Breast	6.5 nTPM

Endothelial cells	5.2 nTPM
Lung	12.5 nTPM
Liver	8.2 nTPM
Endometrium	6.1 nTPM
Skeletal muscle	5.7 nTPM
Prostate	5.6 nTPM
Testis	5.4 nTPM
Ovary	5.4 nTPM
Esophagus	5.1 nTPM
Eye	4.1 nTPM
Pancreas	3.9 nTPM
Breast	3.8 nTPM
Skin	3.5 nTPM
Heart muscle	2.9 nTPM
Placenta	0.6 nTPM

Fibroblasts	5.7 nTPM
Lung	11.1 nTPM
Stomach	7.4 nTPM
Skeletal muscle	7.0 nTPM
Heart muscle	6.4 nTPM
Adipose tissue	6.1 nTPM
Prostate	5.9 nTPM
Ovary	5.2 nTPM
Skin	4.0 nTPM
Placenta	3.7 nTPM
Breast	3.6 nTPM
Esophagus	2.8 nTPM

Intestinal goblet cells	12.4 nTPM
Colon	13.6 nTPM
Rectum	12.8 nTPM
Small intestine	10.7 nTPM

Macrophages	11.9 nTPM
Spleen	36.3 nTPM
Bone marrow	33.8 nTPM
Kidney	18.9 nTPM
Adipose tissue	15.0 nTPM
Endometrium	11.6 nTPM
Skeletal muscle	11.3 nTPM
Lung	8.8 nTPM
Esophagus	7.9 nTPM
Prostate	6.9 nTPM
Breast	6.6 nTPM
Testis	6.4 nTPM
Stomach	5.9 nTPM
Pancreas	5.1 nTPM
Ovary	4.4 nTPM
PBMC	0.0 nTPM

Paneth cells	8.9 nTPM
Rectum	16.8 nTPM
Colon	9.9 nTPM
Small intestine	0.0 nTPM

Plasma cells	7.9 nTPM
Bone marrow	11.5 nTPM
Spleen	11.0 nTPM
Adipose tissue	10.3 nTPM
Stomach	6.8 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	6.8 nTPM
Bronchus	9.3 nTPM
Lung	4.4 nTPM

Smooth muscle cells	4.1 nTPM
Bronchus	8.6 nTPM
Ovary	7.2 nTPM
Endometrium	6.0 nTPM
Adipose tissue	5.4 nTPM
Prostate	5.3 nTPM
Breast	3.6 nTPM
Skin	3.2 nTPM
Skeletal muscle	3.1 nTPM
Pancreas	2.9 nTPM
Heart muscle	0.6 nTPM
Esophagus	0.0 nTPM

T-cells	7.4 nTPM
Adipose tissue	16.3 nTPM
Colon	11.9 nTPM
Spleen	11.3 nTPM
Stomach	11.1 nTPM
Endometrium	10.9 nTPM
Lung	9.1 nTPM
Breast	8.5 nTPM
PBMC	7.0 nTPM
Skeletal muscle	6.7 nTPM
Esophagus	6.6 nTPM
Bone marrow	6.2 nTPM
Lymph node	5.6 nTPM
Prostate	4.7 nTPM
Skin	4.1 nTPM
Liver	3.0 nTPM
Ovary	2.2 nTPM
Kidney	0.7 nTPM

Basal keratinocytes	7.5 nTPM
Skin	7.5 nTPM

Basal prostatic cells	13.5 nTPM
Prostate	13.5 nTPM

Basal squamous epithelial cells	10.8 nTPM
Esophagus	10.8 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Undifferentiated cells	16.7 nTPM
Rectum	18.0 nTPM
Colon	17.6 nTPM
Small intestine	14.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC