Single cell type - PSMB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMB2
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome 20S subunit beta 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PSMB2 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PSMB3	Proteasome 20S subunit beta 3	0.9103	10
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.8617	10
GSTA5	Glutathione S-transferase alpha 5	0.8578	10
ANGPTL6	Angiopoietin like 6	0.8494	10
FCF1	FCF1 rRNA-processing protein	0.8456	10
PSMA5	Proteasome 20S subunit alpha 5	0.8345	10
NUTF2	Nuclear transport factor 2	0.8287	10
PARL	Presenilin associated rhomboid like	0.8222	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.8194	10
ZMAT5	Zinc finger matrin-type 5	0.8118	10
ESD	Esterase D	0.8113	10
TMEM60	Transmembrane protein 60	0.8112	10
PSMB6	Proteasome 20S subunit beta 6	0.8085	10
POTEM	POTE ankyrin domain family member M	0.8064	10
PSMB5	Proteasome 20S subunit beta 5	0.7988	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	110.8 nTPM
Breast	135.5 nTPM
Adipose tissue	86.1 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	68.9 nTPM
Lung	68.9 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	80.4 nTPM
Liver	241.2 nTPM
Kidney	76.1 nTPM
Colon	75.1 nTPM
Stomach	71.8 nTPM
Spleen	66.5 nTPM
Breast	64.1 nTPM
PBMC	62.8 nTPM
Adipose tissue	60.2 nTPM
Lymph node	43.4 nTPM
Bone marrow	42.5 nTPM

Dendritic cells	83.6 nTPM
PBMC	95.6 nTPM
Breast	78.0 nTPM
Adipose tissue	77.1 nTPM

Endothelial cells	115.9 nTPM
Pancreas	262.5 nTPM
Prostate	193.4 nTPM
Placenta	186.4 nTPM
Ovary	138.8 nTPM
Testis	100.8 nTPM
Liver	97.3 nTPM
Eye	95.5 nTPM
Endometrium	90.7 nTPM
Breast	88.0 nTPM
Skeletal muscle	84.4 nTPM
Heart muscle	78.8 nTPM
Lung	77.9 nTPM
Skin	70.5 nTPM
Esophagus	57.8 nTPM

Fibroblasts	101.3 nTPM
Placenta	164.7 nTPM
Prostate	163.1 nTPM
Ovary	128.6 nTPM
Adipose tissue	112.2 nTPM
Breast	93.4 nTPM
Stomach	87.6 nTPM
Lung	81.5 nTPM
Heart muscle	74.5 nTPM
Skeletal muscle	73.8 nTPM
Esophagus	69.0 nTPM
Skin	65.5 nTPM

Intestinal goblet cells	96.9 nTPM
Colon	125.0 nTPM
Small intestine	86.2 nTPM
Rectum	79.6 nTPM

Macrophages	94.1 nTPM
Kidney	142.2 nTPM
Pancreas	135.2 nTPM
Prostate	120.3 nTPM
Lung	101.8 nTPM
Ovary	101.0 nTPM
Testis	97.6 nTPM
Stomach	96.7 nTPM
Endometrium	88.5 nTPM
PBMC	81.8 nTPM
Adipose tissue	81.1 nTPM
Breast	80.6 nTPM
Spleen	75.7 nTPM
Bone marrow	72.4 nTPM
Esophagus	70.8 nTPM
Skeletal muscle	65.0 nTPM

Paneth cells	76.6 nTPM
Small intestine	101.4 nTPM
Rectum	82.4 nTPM
Colon	46.1 nTPM

Plasma cells	141.7 nTPM
Spleen	255.3 nTPM
Bone marrow	209.3 nTPM
Stomach	129.2 nTPM
Esophagus	74.0 nTPM
Adipose tissue	40.7 nTPM

Respiratory ciliated cells	126.8 nTPM
Bronchus	179.3 nTPM
Lung	74.4 nTPM

Smooth muscle cells	291.4 nTPM
Bronchus	2101.6 nTPM
Pancreas	288.1 nTPM
Ovary	150.3 nTPM
Prostate	128.8 nTPM
Breast	107.4 nTPM
Skeletal muscle	90.3 nTPM
Adipose tissue	82.4 nTPM
Endometrium	70.3 nTPM
Heart muscle	67.7 nTPM
Skin	63.8 nTPM
Esophagus	54.3 nTPM

T-cells	81.4 nTPM
Kidney	128.7 nTPM
Ovary	124.6 nTPM
Liver	99.3 nTPM
Prostate	89.9 nTPM
Stomach	87.5 nTPM
Colon	86.5 nTPM
Spleen	81.4 nTPM
PBMC	80.8 nTPM
Skin	80.6 nTPM
Adipose tissue	80.3 nTPM
Bone marrow	75.1 nTPM
Skeletal muscle	65.4 nTPM
Endometrium	65.2 nTPM
Breast	65.2 nTPM
Lung	63.8 nTPM
Esophagus	58.9 nTPM
Lymph node	50.0 nTPM

Basal keratinocytes	111.1 nTPM
Skin	111.1 nTPM

Basal prostatic cells	145.2 nTPM
Prostate	145.2 nTPM

Basal respiratory cells	298.5 nTPM
Bronchus	298.5 nTPM

Basal squamous epithelial cells	50.7 nTPM
Esophagus	50.7 nTPM

Undifferentiated cells	111.7 nTPM
Colon	132.5 nTPM
Small intestine	120.3 nTPM
Rectum	82.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC