Single cell type - UBA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBA2
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin like modifier activating enzyme 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Sertoli cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Sertoli cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBA2 is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GJC1	Gap junction protein gamma 1	0.7942	48
REM1	RRAD and GEM like GTPase 1	0.6936	48
GPR20	G protein-coupled receptor 20	0.6752	48
COX4I2	Cytochrome c oxidase subunit 4I2	0.6714	48
RERGL	RERG like	0.6700	48
NMD3	NMD3 ribosome export adaptor	0.6689	10
GJA4	Gap junction protein alpha 4	0.6652	48
NOTCH3	Notch receptor 3	0.6634	48
RGS5	Regulator of G protein signaling 5	0.6576	48
HIGD1B	HIG1 hypoxia inducible domain family member 1B	0.6515	48
MYH11	Myosin heavy chain 11	0.6481	48
CSPG4	Chondroitin sulfate proteoglycan 4	0.6409	48
NGF	Nerve growth factor	0.6338	10
NT5DC2	5'-nucleotidase domain containing 2	0.6223	48
MCAM	Melanoma cell adhesion molecule	0.6215	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	58.9 nTPM
Breast	70.9 nTPM
Adipose tissue	46.9 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	35.3 nTPM
Lung	35.3 nTPM

Astrocytes	25.5 nTPM
Brain	25.5 nTPM

B-cells	62.1 nTPM
Lymph node	86.1 nTPM
Spleen	83.0 nTPM
Stomach	80.4 nTPM
Bone marrow	68.7 nTPM
Liver	63.8 nTPM
Adipose tissue	54.6 nTPM
PBMC	52.9 nTPM
Colon	49.5 nTPM
Kidney	47.6 nTPM
Breast	34.7 nTPM

Dendritic cells	53.3 nTPM
Breast	66.3 nTPM
Adipose tissue	57.7 nTPM
PBMC	35.8 nTPM

Endothelial cells	55.9 nTPM
Eye	106.0 nTPM
Prostate	86.1 nTPM
Pancreas	65.6 nTPM
Skeletal muscle	58.6 nTPM
Breast	57.1 nTPM
Skin	54.0 nTPM
Testis	53.0 nTPM
Ovary	51.8 nTPM
Lung	49.9 nTPM
Endometrium	47.4 nTPM
Esophagus	41.7 nTPM
Heart muscle	40.2 nTPM
Placenta	39.8 nTPM
Liver	31.2 nTPM

Fibroblasts	56.4 nTPM
Prostate	91.8 nTPM
Ovary	76.4 nTPM
Adipose tissue	63.7 nTPM
Stomach	62.4 nTPM
Placenta	60.4 nTPM
Skin	52.2 nTPM
Skeletal muscle	47.5 nTPM
Esophagus	44.7 nTPM
Lung	43.6 nTPM
Breast	39.1 nTPM
Heart muscle	38.9 nTPM

Intestinal goblet cells	32.8 nTPM
Rectum	37.5 nTPM
Small intestine	34.5 nTPM
Colon	26.4 nTPM

Macrophages	40.4 nTPM
Adipose tissue	57.6 nTPM
Stomach	55.7 nTPM
Testis	54.6 nTPM
Ovary	48.3 nTPM
Bone marrow	45.0 nTPM
Skeletal muscle	42.6 nTPM
Spleen	41.4 nTPM
Prostate	41.3 nTPM
Esophagus	40.9 nTPM
Breast	40.5 nTPM
Lung	38.5 nTPM
Endometrium	36.6 nTPM
Kidney	31.8 nTPM
Pancreas	30.7 nTPM
PBMC	0.0 nTPM

Paneth cells	23.9 nTPM
Rectum	39.4 nTPM
Small intestine	22.5 nTPM
Colon	9.9 nTPM

Plasma cells	74.5 nTPM
Spleen	121.3 nTPM
Bone marrow	108.8 nTPM
Stomach	84.5 nTPM
Adipose tissue	39.4 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	29.7 nTPM
Lung	32.1 nTPM
Bronchus	27.2 nTPM

Smooth muscle cells	206.5 nTPM
Skeletal muscle	264.5 nTPM
Adipose tissue	264.0 nTPM
Bronchus	262.0 nTPM
Skin	240.7 nTPM
Breast	235.0 nTPM
Heart muscle	228.2 nTPM
Esophagus	227.9 nTPM
Prostate	198.1 nTPM
Ovary	157.6 nTPM
Endometrium	126.0 nTPM
Pancreas	67.4 nTPM

T-cells	58.6 nTPM
Stomach	85.1 nTPM
Lymph node	84.9 nTPM
Ovary	84.5 nTPM
Spleen	73.9 nTPM
Bone marrow	69.4 nTPM
PBMC	67.6 nTPM
Skeletal muscle	62.0 nTPM
Colon	59.4 nTPM
Skin	59.4 nTPM
Adipose tissue	57.7 nTPM
Breast	57.1 nTPM
Kidney	45.8 nTPM
Liver	42.9 nTPM
Esophagus	39.3 nTPM
Endometrium	38.9 nTPM
Prostate	37.9 nTPM
Lung	30.4 nTPM

Basal keratinocytes	87.1 nTPM
Skin	87.1 nTPM

Basal prostatic cells	72.5 nTPM
Prostate	72.5 nTPM

Basal respiratory cells	36.4 nTPM
Bronchus	36.4 nTPM

Basal squamous epithelial cells	59.7 nTPM
Esophagus	59.7 nTPM

Undifferentiated cells	45.4 nTPM
Small intestine	48.9 nTPM
Colon	44.2 nTPM
Rectum	42.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC