Single cell type - ORMDL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ORMDL1
Gene descriptionⁱ Full gene name according to HGNC.	ORMDL sphingolipid biosynthesis regulator 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ORMDL1 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLF1	SMC5-SMC6 complex localization factor 1	0.5609	13
ZSWIM7	Zinc finger SWIM-type containing 7	0.5354	39
LRPAP1	LDL receptor related protein associated protein 1	0.5237	47
MED6	Mediator complex subunit 6	0.5122	52
ZFYVE19	Zinc finger FYVE-type containing 19	0.5106	47
ZNF7	Zinc finger protein 7	0.5096	52
SLC7A6OS	Solute carrier family 7 member 6 opposite strand	0.5032	52
TEX264	Testis expressed 264, ER-phagy receptor	0.5015	13
ESCO1	Establishment of sister chromatid cohesion N-acetyltransferase 1	0.4938	52
RAD1	RAD1 checkpoint DNA exonuclease	0.4929	47
SDF2	Stromal cell derived factor 2	0.4916	26
AASDH	Aminoadipate-semialdehyde dehydrogenase	0.4858	52
DNMT1	DNA methyltransferase 1	0.4851	47
RBAK-RBAKDN	RBAK-RBAKDN readthrough	0.4786	20
SAP25	Sin3A associated protein 25	0.4778	20

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	80.4 nTPM
Breast	107.3 nTPM
Adipose tissue	53.6 nTPM

Alveolar cells type 1	80.1 nTPM
Lung	80.1 nTPM

Alveolar cells type 2	50.2 nTPM
Lung	50.2 nTPM

Astrocytes	41.4 nTPM
Brain	41.4 nTPM

B-cells	90.9 nTPM
Breast	149.7 nTPM
PBMC	127.0 nTPM
Adipose tissue	114.8 nTPM
Kidney	104.8 nTPM
Colon	92.6 nTPM
Liver	92.4 nTPM
Spleen	68.9 nTPM
Lymph node	66.2 nTPM
Bone marrow	47.4 nTPM
Stomach	45.0 nTPM

Dendritic cells	141.2 nTPM
Breast	179.7 nTPM
Adipose tissue	152.2 nTPM
PBMC	91.6 nTPM

Endothelial cells	61.8 nTPM
Pancreas	96.5 nTPM
Prostate	92.5 nTPM
Lung	77.9 nTPM
Placenta	77.9 nTPM
Breast	74.7 nTPM
Ovary	65.9 nTPM
Eye	61.5 nTPM
Testis	57.8 nTPM
Skin	50.8 nTPM
Endometrium	50.7 nTPM
Skeletal muscle	44.2 nTPM
Liver	42.2 nTPM
Heart muscle	41.4 nTPM
Esophagus	30.4 nTPM

Fibroblasts	58.1 nTPM
Prostate	86.9 nTPM
Breast	86.4 nTPM
Ovary	79.5 nTPM
Placenta	75.5 nTPM
Adipose tissue	63.9 nTPM
Heart muscle	57.4 nTPM
Skin	48.0 nTPM
Skeletal muscle	45.6 nTPM
Lung	44.6 nTPM
Esophagus	35.0 nTPM
Stomach	16.3 nTPM

Intestinal goblet cells	37.2 nTPM
Small intestine	38.5 nTPM
Colon	37.1 nTPM
Rectum	35.9 nTPM

Macrophages	83.3 nTPM
Ovary	160.3 nTPM
Testis	125.4 nTPM
Prostate	114.6 nTPM
Breast	112.8 nTPM
Pancreas	109.7 nTPM
Adipose tissue	91.0 nTPM
Skeletal muscle	76.5 nTPM
Kidney	70.4 nTPM
Lung	66.4 nTPM
Bone marrow	66.2 nTPM
Spleen	65.3 nTPM
Stomach	64.5 nTPM
Endometrium	63.9 nTPM
Esophagus	34.6 nTPM
PBMC	27.3 nTPM

Paneth cells	48.3 nTPM
Small intestine	56.3 nTPM
Rectum	52.6 nTPM
Colon	36.2 nTPM

Plasma cells	83.5 nTPM
Spleen	97.6 nTPM
Adipose tissue	95.5 nTPM
Esophagus	86.2 nTPM
Bone marrow	69.2 nTPM
Stomach	68.7 nTPM

Respiratory ciliated cells	66.3 nTPM
Lung	68.5 nTPM
Bronchus	64.1 nTPM

Smooth muscle cells	63.8 nTPM
Ovary	118.0 nTPM
Pancreas	95.1 nTPM
Heart muscle	93.5 nTPM
Breast	81.5 nTPM
Adipose tissue	58.2 nTPM
Prostate	51.9 nTPM
Skin	51.6 nTPM
Endometrium	51.3 nTPM
Skeletal muscle	46.3 nTPM
Esophagus	29.4 nTPM
Bronchus	25.4 nTPM

T-cells	104.5 nTPM
Ovary	175.7 nTPM
Breast	164.8 nTPM
Colon	137.3 nTPM
PBMC	136.2 nTPM
Adipose tissue	133.5 nTPM
Kidney	112.9 nTPM
Skeletal muscle	109.7 nTPM
Skin	102.7 nTPM
Lymph node	98.6 nTPM
Lung	94.2 nTPM
Spleen	91.5 nTPM
Liver	90.8 nTPM
Prostate	85.2 nTPM
Bone marrow	71.0 nTPM
Endometrium	68.4 nTPM
Stomach	64.6 nTPM
Esophagus	39.3 nTPM

Basal prostatic cells	55.1 nTPM
Prostate	55.1 nTPM

Basal respiratory cells	95.6 nTPM
Bronchus	95.6 nTPM

Basal squamous epithelial cells	26.7 nTPM
Esophagus	26.7 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Undifferentiated cells	46.3 nTPM
Small intestine	51.6 nTPM
Colon	45.2 nTPM
Rectum	42.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC