Single cell type - ARPP19 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARPP19
Gene descriptionⁱ Full gene name according to HGNC.	CAMP regulated phosphoprotein 19
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ARPP19 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM187B	Family with sequence similarity 187 member B	0.8800	31
PRM1	Protamine 1	0.8656	31
PRM3	Protamine 3	0.8574	31
PRH2	Proline rich protein HaeIII subfamily 2	0.8557	31
C20orf141	Chromosome 20 open reading frame 141	0.8536	31
C11orf42	Chromosome 11 open reading frame 42	0.8491	31
RABIF	RAB interacting factor	0.8491	31
TSACC	TSSK6 activating cochaperone	0.8479	31
ARL9	ADP ribosylation factor like GTPase 9	0.8476	31
SPANXD	SPANX family member D	0.8425	31
CYLC1	Cylicin 1	0.8396	31
SLC6A5	Solute carrier family 6 member 5	0.8385	31
KRT74	Keratin 74	0.8378	31
DGCR6	DiGeorge syndrome critical region gene 6	0.8354	31
CT83	Cancer/testis antigen 83	0.8349	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	90.8 nTPM
Adipose tissue	104.0 nTPM
Breast	77.6 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	59.4 nTPM
Lung	59.4 nTPM

Astrocytes	33.6 nTPM
Brain	33.6 nTPM

B-cells	93.9 nTPM
Adipose tissue	188.5 nTPM
Colon	151.8 nTPM
Stomach	108.1 nTPM
Liver	87.6 nTPM
Spleen	87.2 nTPM
Lymph node	67.7 nTPM
Bone marrow	67.0 nTPM
Kidney	61.9 nTPM
PBMC	61.4 nTPM
Breast	57.5 nTPM

Dendritic cells	100.3 nTPM
Adipose tissue	146.6 nTPM
Breast	78.7 nTPM
PBMC	75.7 nTPM

Endothelial cells	83.0 nTPM
Skin	143.9 nTPM
Prostate	117.1 nTPM
Heart muscle	115.4 nTPM
Breast	101.5 nTPM
Eye	81.7 nTPM
Ovary	77.9 nTPM
Endometrium	72.7 nTPM
Placenta	71.6 nTPM
Skeletal muscle	70.5 nTPM
Esophagus	68.3 nTPM
Testis	67.3 nTPM
Liver	64.2 nTPM
Lung	59.3 nTPM
Pancreas	50.2 nTPM

Fibroblasts	73.7 nTPM
Prostate	132.8 nTPM
Heart muscle	106.4 nTPM
Skin	99.3 nTPM
Lung	90.4 nTPM
Adipose tissue	69.0 nTPM
Breast	62.4 nTPM
Placenta	56.2 nTPM
Stomach	53.4 nTPM
Ovary	52.7 nTPM
Skeletal muscle	45.1 nTPM
Esophagus	42.7 nTPM

Intestinal goblet cells	45.6 nTPM
Rectum	51.6 nTPM
Small intestine	44.6 nTPM
Colon	40.7 nTPM

Macrophages	73.4 nTPM
Prostate	137.5 nTPM
Adipose tissue	124.4 nTPM
Testis	107.5 nTPM
Kidney	86.2 nTPM
Ovary	76.7 nTPM
Spleen	68.5 nTPM
PBMC	68.2 nTPM
Endometrium	59.8 nTPM
Esophagus	58.3 nTPM
Breast	58.3 nTPM
Bone marrow	56.3 nTPM
Lung	52.1 nTPM
Pancreas	51.0 nTPM
Skeletal muscle	48.8 nTPM
Stomach	46.9 nTPM

Paneth cells	38.1 nTPM
Colon	56.0 nTPM
Rectum	47.1 nTPM
Small intestine	11.3 nTPM

Plasma cells	94.8 nTPM
Spleen	119.3 nTPM
Adipose tissue	118.7 nTPM
Stomach	107.0 nTPM
Esophagus	67.8 nTPM
Bone marrow	61.0 nTPM

Respiratory ciliated cells	62.7 nTPM
Bronchus	90.5 nTPM
Lung	35.0 nTPM

Smooth muscle cells	131.1 nTPM
Bronchus	598.0 nTPM
Heart muscle	138.0 nTPM
Prostate	130.7 nTPM
Skin	102.2 nTPM
Esophagus	85.3 nTPM
Adipose tissue	77.9 nTPM
Breast	68.0 nTPM
Pancreas	63.0 nTPM
Endometrium	62.7 nTPM
Skeletal muscle	59.3 nTPM
Ovary	57.5 nTPM

T-cells	95.0 nTPM
Skin	213.7 nTPM
Adipose tissue	196.1 nTPM
Colon	133.0 nTPM
Prostate	118.3 nTPM
Stomach	101.0 nTPM
Breast	90.5 nTPM
Kidney	85.6 nTPM
Endometrium	78.2 nTPM
Ovary	77.9 nTPM
Spleen	77.7 nTPM
Liver	75.1 nTPM
Skeletal muscle	71.7 nTPM
Esophagus	65.5 nTPM
Bone marrow	63.4 nTPM
Lung	59.2 nTPM
Lymph node	56.9 nTPM
PBMC	51.4 nTPM

Basal keratinocytes	215.7 nTPM
Skin	215.7 nTPM

Basal prostatic cells	190.7 nTPM
Prostate	190.7 nTPM

Basal respiratory cells	142.2 nTPM
Bronchus	142.2 nTPM

Basal squamous epithelial cells	55.8 nTPM
Esophagus	55.8 nTPM

Undifferentiated cells	43.4 nTPM
Colon	44.9 nTPM
Rectum	43.5 nTPM
Small intestine	41.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC