Single cell type - RNASE1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNASE1
Gene descriptionⁱ Full gene name according to HGNC.	Ribonuclease A family member 1, pancreatic
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Alveolar cells type 1, Adipocytes, Gastric mucus-secreting cells, Alveolar cells type 2, Intestinal goblet cells, Hepatic stellate cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (myeloid DC, classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HUVEC TERT2, OE19, RT4, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Alveolar cells type 1, Adipocytes, Gastric mucus-secreting cells, Alveolar cells type 2, Intestinal goblet cells, Hepatic stellate cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RNASE1 is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LILRB5	Leukocyte immunoglobulin like receptor B5	0.7853	4
CD209	CD209 molecule	0.7821	4
STAB1	Stabilin 1	0.7555	4
FOLR2	Folate receptor beta	0.7485	4
SIGLEC1	Sialic acid binding Ig like lectin 1	0.7393	4
FCGR2B	Fc fragment of IgG receptor IIb	0.7323	4
CD163	CD163 molecule	0.7273	4
MS4A4A	Membrane spanning 4-domains A4A	0.7234	4
C1QC	Complement C1q C chain	0.7187	4
GPR34	G protein-coupled receptor 34	0.7166	4
MS4A4E	Membrane spanning 4-domains A4E	0.7068	4
C1QA	Complement C1q A chain	0.7044	4
ADPRH	ADP-ribosylarginine hydrolase	0.6938	4
C1QB	Complement C1q B chain	0.6730	4
CSF1R	Colony stimulating factor 1 receptor	0.6728	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	11.1 nTPM
Kidney	47.6 nTPM
Breast	17.3 nTPM
Colon	16.0 nTPM
Liver	13.8 nTPM
Stomach	10.9 nTPM
Adipose tissue	2.5 nTPM
Lymph node	2.2 nTPM
Spleen	0.7 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	35.6 nTPM
Skin	35.6 nTPM

Basal prostatic cells	1.0 nTPM
Prostate	1.0 nTPM

Basal respiratory cells	1.9 nTPM
Bronchus	1.9 nTPM

Adipocytes	826.6 nTPM
Breast	968.1 nTPM
Adipose tissue	685.1 nTPM

Dendritic cells	5.7 nTPM
Breast	10.2 nTPM
Adipose tissue	6.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	581.7 nTPM
Liver	1233.6 nTPM
Heart muscle	1203.7 nTPM
Skeletal muscle	949.3 nTPM
Placenta	897.0 nTPM
Esophagus	706.8 nTPM
Testis	570.9 nTPM
Ovary	507.1 nTPM
Breast	462.6 nTPM
Endometrium	444.8 nTPM
Prostate	357.1 nTPM
Eye	330.9 nTPM
Skin	244.8 nTPM
Lung	162.2 nTPM
Pancreas	73.4 nTPM

Fibroblasts	58.4 nTPM
Ovary	230.4 nTPM
Stomach	123.3 nTPM
Heart muscle	106.6 nTPM
Lung	54.7 nTPM
Placenta	43.2 nTPM
Skin	31.3 nTPM
Esophagus	14.9 nTPM
Skeletal muscle	13.2 nTPM
Breast	10.0 nTPM
Prostate	7.6 nTPM
Adipose tissue	7.1 nTPM

Intestinal goblet cells	663.8 nTPM
Rectum	805.5 nTPM
Colon	783.3 nTPM
Small intestine	402.6 nTPM

Macrophages	632.8 nTPM
Esophagus	4122.8 nTPM
Testis	1514.5 nTPM
Adipose tissue	1242.9 nTPM
Skeletal muscle	1138.9 nTPM
Breast	498.0 nTPM
Ovary	373.2 nTPM
Prostate	214.4 nTPM
Stomach	96.7 nTPM
Kidney	91.5 nTPM
Lung	73.7 nTPM
Spleen	52.9 nTPM
Endometrium	31.8 nTPM
Bone marrow	30.0 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	246.7 nTPM
Colon	619.3 nTPM
Rectum	87.0 nTPM
Small intestine	33.8 nTPM

Plasma cells	7.5 nTPM
Stomach	13.0 nTPM
Esophagus	12.3 nTPM
Adipose tissue	12.2 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	34.9 nTPM
Lung	64.1 nTPM
Bronchus	5.7 nTPM

Smooth muscle cells	31.4 nTPM
Heart muscle	188.5 nTPM
Breast	38.2 nTPM
Skeletal muscle	31.9 nTPM
Ovary	24.8 nTPM
Skin	21.7 nTPM
Esophagus	12.4 nTPM
Adipose tissue	10.6 nTPM
Pancreas	6.9 nTPM
Bronchus	5.6 nTPM
Endometrium	3.6 nTPM
Prostate	1.5 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Collecting duct cells	16.5 nTPM
Kidney	16.5 nTPM

Cytotrophoblasts	12.9 nTPM
Placenta	12.9 nTPM

Distal enterocytes	261.8 nTPM
Colon	287.1 nTPM
Rectum	236.6 nTPM

T-cells	10.6 nTPM
Lung	77.5 nTPM
Skin	27.6 nTPM
Skeletal muscle	19.9 nTPM
Kidney	11.6 nTPM
Breast	11.5 nTPM
Colon	8.1 nTPM
Liver	7.5 nTPM
Stomach	6.6 nTPM
Endometrium	4.2 nTPM
Adipose tissue	4.0 nTPM
Lymph node	2.0 nTPM
Bone marrow	0.1 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	162.9 nTPM
Rectum	193.4 nTPM
Small intestine	184.2 nTPM
Colon	111.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC