Single cell type - MAP7D3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAP7D3
Gene descriptionⁱ Full gene name according to HGNC.	MAP7 domain containing 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids, Spermatogonia)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids, Spermatogonia)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAP7D3 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRRX1	Paired related homeobox 1	0.6643	50
FAM76A	Family with sequence similarity 76 member A	0.6611	50
PALM2AKAP2	PALM2 and AKAP2 fusion	0.5864	50
TMA16	Translation machinery associated 16 homolog	0.5611	66
MXRA8	Matrix remodeling associated 8	0.5560	50
LHFPL6	LHFPL tetraspan subfamily member 6	0.5546	50
C5orf58	Chromosome 5 open reading frame 58	0.5416	50
TMDD1	Transmembrane and death domain 1	0.5399	50
CCN5	Cellular communication network factor 5	0.5375	50
NID1	Nidogen 1	0.5298	36
DENND2B	DENN domain containing 2B	0.5284	50
CCN2	Cellular communication network factor 2	0.5273	50
VGLL3	Vestigial like family member 3	0.5271	38
SEPTIN10	Septin 10	0.5259	24
GASK1A	Golgi associated kinase 1A	0.5254	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.6 nTPM
Adipose tissue	46.9 nTPM
Breast	26.2 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	6.7 nTPM
Lung	6.7 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	18.5 nTPM
Liver	25.6 nTPM
PBMC	24.3 nTPM
Spleen	22.2 nTPM
Bone marrow	22.1 nTPM
Adipose tissue	20.6 nTPM
Kidney	19.0 nTPM
Lymph node	15.9 nTPM
Breast	14.7 nTPM
Stomach	14.5 nTPM
Colon	6.4 nTPM

Dendritic cells	13.8 nTPM
Adipose tissue	15.3 nTPM
Breast	14.2 nTPM
PBMC	12.0 nTPM

Endothelial cells	24.9 nTPM
Liver	48.6 nTPM
Lung	46.8 nTPM
Pancreas	46.4 nTPM
Breast	31.2 nTPM
Esophagus	23.7 nTPM
Endometrium	23.2 nTPM
Skeletal muscle	23.1 nTPM
Heart muscle	19.9 nTPM
Testis	17.7 nTPM
Ovary	17.3 nTPM
Prostate	15.2 nTPM
Skin	15.1 nTPM
Placenta	12.5 nTPM
Eye	8.1 nTPM

Fibroblasts	46.5 nTPM
Adipose tissue	160.2 nTPM
Heart muscle	55.3 nTPM
Breast	54.9 nTPM
Skeletal muscle	51.2 nTPM
Esophagus	35.5 nTPM
Placenta	31.3 nTPM
Stomach	31.2 nTPM
Lung	30.1 nTPM
Skin	26.9 nTPM
Ovary	19.2 nTPM
Prostate	15.2 nTPM

Intestinal goblet cells	2.8 nTPM
Colon	4.3 nTPM
Small intestine	2.2 nTPM
Rectum	2.0 nTPM

Macrophages	15.0 nTPM
Stomach	23.5 nTPM
Pancreas	23.0 nTPM
Endometrium	21.9 nTPM
Testis	21.5 nTPM
Kidney	21.1 nTPM
Lung	19.6 nTPM
Spleen	17.6 nTPM
Skeletal muscle	14.8 nTPM
Adipose tissue	14.1 nTPM
Breast	12.6 nTPM
Bone marrow	11.3 nTPM
Ovary	9.8 nTPM
Esophagus	7.9 nTPM
Prostate	6.9 nTPM
PBMC	0.0 nTPM

Paneth cells	14.1 nTPM
Colon	19.7 nTPM
Small intestine	15.0 nTPM
Rectum	7.7 nTPM

Plasma cells	10.0 nTPM
Stomach	16.2 nTPM
Adipose tissue	13.6 nTPM
Spleen	12.0 nTPM
Bone marrow	8.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	6.5 nTPM
Lung	7.3 nTPM
Bronchus	5.7 nTPM

Smooth muscle cells	61.5 nTPM
Adipose tissue	134.0 nTPM
Heart muscle	100.4 nTPM
Skeletal muscle	86.9 nTPM
Breast	78.2 nTPM
Esophagus	69.8 nTPM
Endometrium	60.3 nTPM
Skin	57.9 nTPM
Pancreas	38.1 nTPM
Prostate	35.1 nTPM
Ovary	15.2 nTPM
Bronchus	0.9 nTPM

T-cells	18.6 nTPM
Adipose tissue	31.8 nTPM
PBMC	27.9 nTPM
Lung	27.4 nTPM
Liver	26.8 nTPM
Kidney	26.7 nTPM
Endometrium	23.3 nTPM
Skeletal muscle	20.6 nTPM
Colon	19.0 nTPM
Breast	15.6 nTPM
Spleen	15.4 nTPM
Bone marrow	15.0 nTPM
Stomach	14.3 nTPM
Ovary	13.4 nTPM
Lymph node	13.4 nTPM
Skin	9.7 nTPM
Prostate	9.5 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	7.1 nTPM
Skin	7.1 nTPM

Basal prostatic cells	7.2 nTPM
Prostate	7.2 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Undifferentiated cells	3.3 nTPM
Rectum	3.6 nTPM
Colon	3.4 nTPM
Small intestine	2.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC