Single cell type - EXOSC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EXOSC2
Gene descriptionⁱ Full gene name according to HGNC.	Exosome component 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EXOSC2 is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
WDR4	WD repeat domain 4	0.6397	39
BCL2L12	BCL2 like 12	0.6054	12
TK1	Thymidine kinase 1	0.5935	12
PAICS	Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	0.5910	12
SUV39H1	Suppressor of variegation 3-9 homolog 1	0.5695	38
RFC2	Replication factor C subunit 2	0.5686	12
GRWD1	Glutamate rich WD repeat containing 1	0.5667	39
IGHV2-70	Immunoglobulin heavy variable 2-70	0.5587	55
AURKB	Aurora kinase B	0.5563	12
TOMM40	Translocase of outer mitochondrial membrane 40	0.5559	39
CDK4	Cyclin dependent kinase 4	0.5489	39
SRM	Spermidine synthase	0.5430	55
RRM2	Ribonucleotide reductase regulatory subunit M2	0.5359	12
IGHV1-45	Immunoglobulin heavy variable 1-45	0.5349	55
MCM3	Minichromosome maintenance complex component 3	0.5299	12

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.6 nTPM
Breast	7.8 nTPM
Adipose tissue	7.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	20.5 nTPM
Lung	20.5 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	13.5 nTPM
Liver	23.5 nTPM
PBMC	18.6 nTPM
Colon	16.0 nTPM
Spleen	15.3 nTPM
Bone marrow	14.7 nTPM
Stomach	12.7 nTPM
Kidney	9.5 nTPM
Lymph node	9.1 nTPM
Adipose tissue	9.0 nTPM
Breast	6.6 nTPM

Dendritic cells	10.6 nTPM
PBMC	12.0 nTPM
Adipose tissue	10.0 nTPM
Breast	9.9 nTPM

Endothelial cells	8.0 nTPM
Lung	18.7 nTPM
Pancreas	11.6 nTPM
Placenta	9.1 nTPM
Skin	8.7 nTPM
Skeletal muscle	8.6 nTPM
Endometrium	8.1 nTPM
Prostate	7.8 nTPM
Testis	7.4 nTPM
Esophagus	7.3 nTPM
Ovary	7.0 nTPM
Heart muscle	5.7 nTPM
Breast	5.7 nTPM
Eye	4.1 nTPM
Liver	2.7 nTPM

Fibroblasts	9.8 nTPM
Ovary	16.6 nTPM
Lung	13.4 nTPM
Placenta	12.8 nTPM
Prostate	10.5 nTPM
Adipose tissue	9.6 nTPM
Skeletal muscle	8.9 nTPM
Breast	7.6 nTPM
Heart muscle	7.5 nTPM
Stomach	7.4 nTPM
Esophagus	7.3 nTPM
Skin	6.6 nTPM

Intestinal goblet cells	7.9 nTPM
Colon	9.3 nTPM
Small intestine	8.7 nTPM
Rectum	5.8 nTPM

Macrophages	7.8 nTPM
Pancreas	15.3 nTPM
Kidney	12.9 nTPM
Bone marrow	11.3 nTPM
Testis	10.5 nTPM
Lung	8.4 nTPM
Esophagus	7.9 nTPM
Breast	7.6 nTPM
Spleen	7.2 nTPM
Prostate	6.9 nTPM
Endometrium	6.5 nTPM
Ovary	6.5 nTPM
Stomach	5.9 nTPM
Skeletal muscle	5.6 nTPM
Adipose tissue	4.4 nTPM
PBMC	0.0 nTPM

Paneth cells	2.7 nTPM
Rectum	8.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	13.7 nTPM
Spleen	20.1 nTPM
Adipose tissue	15.5 nTPM
Bone marrow	14.8 nTPM
Esophagus	12.3 nTPM
Stomach	5.7 nTPM

Respiratory ciliated cells	6.7 nTPM
Lung	10.2 nTPM
Bronchus	3.2 nTPM

Smooth muscle cells	10.2 nTPM
Pancreas	25.2 nTPM
Prostate	15.0 nTPM
Heart muscle	11.9 nTPM
Skeletal muscle	10.9 nTPM
Skin	9.5 nTPM
Ovary	8.8 nTPM
Endometrium	8.2 nTPM
Adipose tissue	7.9 nTPM
Breast	7.6 nTPM
Esophagus	4.6 nTPM
Bronchus	2.8 nTPM

T-cells	10.1 nTPM
Lung	19.7 nTPM
PBMC	14.9 nTPM
Colon	14.7 nTPM
Liver	11.6 nTPM
Bone marrow	11.5 nTPM
Kidney	10.9 nTPM
Prostate	9.5 nTPM
Skeletal muscle	9.2 nTPM
Spleen	9.2 nTPM
Endometrium	9.1 nTPM
Adipose tissue	9.1 nTPM
Stomach	8.6 nTPM
Lymph node	7.2 nTPM
Breast	7.0 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Skin	6.0 nTPM

Basal prostatic cells	12.6 nTPM
Prostate	12.6 nTPM

Basal respiratory cells	7.7 nTPM
Bronchus	7.7 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Undifferentiated cells	10.0 nTPM
Small intestine	12.3 nTPM
Rectum	9.7 nTPM
Colon	8.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC