Single cell type - RRP8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRP8
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal RNA processing 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RRP8 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GCDH	Glutaryl-CoA dehydrogenase	0.5069	67
DECR2	2,4-dienoyl-CoA reductase 2	0.4706	67
ZNF30	Zinc finger protein 30	0.4675	62
SLC25A21	Solute carrier family 25 member 21	0.4534	6
GADD45GIP1	GADD45G interacting protein 1	0.4500	39
COA4	Cytochrome c oxidase assembly factor 4 homolog	0.4476	39
DDX18	DEAD-box helicase 18	0.4437	39
RIC8B	RIC8 guanine nucleotide exchange factor B	0.4424	8
TRUB2	TruB pseudouridine synthase family member 2	0.4318	39
AFP	Alpha fetoprotein	0.4247	67
DDX10	DEAD-box helicase 10	0.4218	67
RRP15	Ribosomal RNA processing 15 homolog	0.4214	39
PTH2R	Parathyroid hormone 2 receptor	0.4212	46
SLIRP	SRA stem-loop interacting RNA binding protein	0.4193	39
GNL3L	G protein nucleolar 3 like	0.4161	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.0 nTPM
Adipose tissue	18.0 nTPM
Breast	16.0 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	15.0 nTPM
Lung	15.0 nTPM

Astrocytes	37.2 nTPM
Brain	37.2 nTPM

B-cells	19.6 nTPM
PBMC	31.5 nTPM
Adipose tissue	26.6 nTPM
Stomach	22.3 nTPM
Colon	20.8 nTPM
Kidney	19.0 nTPM
Bone marrow	18.8 nTPM
Spleen	18.7 nTPM
Lymph node	14.2 nTPM
Liver	13.8 nTPM
Breast	10.7 nTPM

Dendritic cells	20.7 nTPM
Adipose tissue	28.7 nTPM
Breast	21.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	16.4 nTPM
Lung	18.7 nTPM
Skin	18.7 nTPM
Endometrium	18.6 nTPM
Heart muscle	18.4 nTPM
Placenta	18.2 nTPM
Testis	18.1 nTPM
Ovary	17.3 nTPM
Eye	16.2 nTPM
Pancreas	15.5 nTPM
Prostate	15.3 nTPM
Skeletal muscle	15.3 nTPM
Breast	14.5 nTPM
Esophagus	13.4 nTPM
Liver	11.9 nTPM

Fibroblasts	15.5 nTPM
Lung	20.1 nTPM
Adipose tissue	18.7 nTPM
Prostate	18.2 nTPM
Placenta	16.3 nTPM
Stomach	16.3 nTPM
Skeletal muscle	15.5 nTPM
Skin	15.2 nTPM
Breast	15.1 nTPM
Ovary	13.3 nTPM
Heart muscle	12.6 nTPM
Esophagus	9.6 nTPM

Intestinal goblet cells	16.2 nTPM
Colon	19.3 nTPM
Small intestine	16.3 nTPM
Rectum	12.8 nTPM

Macrophages	13.1 nTPM
Testis	20.9 nTPM
Ovary	16.9 nTPM
Endometrium	16.1 nTPM
Breast	14.9 nTPM
Adipose tissue	14.8 nTPM
Skeletal muscle	14.1 nTPM
Kidney	13.7 nTPM
PBMC	13.6 nTPM
Lung	13.2 nTPM
Pancreas	12.8 nTPM
Prostate	12.6 nTPM
Spleen	10.4 nTPM
Esophagus	9.4 nTPM
Stomach	8.8 nTPM
Bone marrow	3.7 nTPM

Paneth cells	18.2 nTPM
Small intestine	30.0 nTPM
Rectum	14.7 nTPM
Colon	9.9 nTPM

Plasma cells	15.2 nTPM
Spleen	21.4 nTPM
Adipose tissue	18.8 nTPM
Stomach	16.5 nTPM
Bone marrow	13.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	10.3 nTPM
Lung	11.7 nTPM
Bronchus	8.9 nTPM

Smooth muscle cells	20.0 nTPM
Heart muscle	37.3 nTPM
Esophagus	26.4 nTPM
Pancreas	24.2 nTPM
Adipose tissue	22.8 nTPM
Skin	21.3 nTPM
Breast	20.0 nTPM
Prostate	19.1 nTPM
Skeletal muscle	17.5 nTPM
Endometrium	16.2 nTPM
Ovary	13.1 nTPM
Bronchus	2.0 nTPM

T-cells	17.7 nTPM
Kidney	30.7 nTPM
Lung	28.8 nTPM
Adipose tissue	25.3 nTPM
PBMC	22.5 nTPM
Bone marrow	21.1 nTPM
Liver	20.3 nTPM
Endometrium	19.5 nTPM
Stomach	18.9 nTPM
Colon	16.6 nTPM
Breast	16.0 nTPM
Skeletal muscle	15.7 nTPM
Skin	15.2 nTPM
Spleen	15.1 nTPM
Esophagus	13.1 nTPM
Lymph node	11.5 nTPM
Ovary	11.1 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	23.2 nTPM
Skin	23.2 nTPM

Basal prostatic cells	18.5 nTPM
Prostate	18.5 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	17.3 nTPM
Colon	21.0 nTPM
Rectum	16.3 nTPM
Small intestine	14.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC