Single cell type - ZMYM5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZMYM5
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger MYM-type containing 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZMYM5 is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C12orf65	Chromosome 12 open reading frame 65	0.6458	7
RSRP1	Arginine and serine rich protein 1	0.6110	7
KRIT1	KRIT1 ankyrin repeat containing	0.5572	13
CLASRP	CLK4 associating serine/arginine rich protein	0.5568	13
ZNF250	Zinc finger protein 250	0.5512	7
ZNF800	Zinc finger protein 800	0.5498	59
IQCB1	IQ motif containing B1	0.5470	13
SENP1	SUMO specific peptidase 1	0.5358	13
ZNF92	Zinc finger protein 92	0.5355	57
DPH7	Diphthamide biosynthesis 7	0.5295	13
FUS	FUS RNA binding protein	0.5228	7
PXT1	Peroxisomal testis enriched protein 1	0.5207	13
BRD2	Bromodomain containing 2	0.5176	7
MDC1	Mediator of DNA damage checkpoint 1	0.5174	13
WDR75	WD repeat domain 75	0.5088	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.1 nTPM
Breast	39.5 nTPM
Adipose tissue	28.7 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	17.3 nTPM
Lung	17.3 nTPM

Astrocytes	33.0 nTPM
Brain	33.0 nTPM

B-cells	35.7 nTPM
Lymph node	75.7 nTPM
Bone marrow	52.3 nTPM
Spleen	51.5 nTPM
Adipose tissue	42.2 nTPM
Stomach	39.1 nTPM
Breast	37.5 nTPM
Colon	25.5 nTPM
PBMC	21.4 nTPM
Liver	12.1 nTPM
Kidney	0.0 nTPM

Dendritic cells	32.4 nTPM
Breast	43.8 nTPM
Adipose tissue	37.6 nTPM
PBMC	16.0 nTPM

Endothelial cells	21.3 nTPM
Esophagus	34.0 nTPM
Heart muscle	33.8 nTPM
Breast	27.3 nTPM
Endometrium	26.6 nTPM
Skeletal muscle	26.3 nTPM
Prostate	23.5 nTPM
Testis	22.2 nTPM
Lung	21.8 nTPM
Ovary	20.9 nTPM
Skin	16.5 nTPM
Eye	15.4 nTPM
Liver	11.9 nTPM
Placenta	9.7 nTPM
Pancreas	7.7 nTPM

Fibroblasts	24.4 nTPM
Prostate	39.7 nTPM
Breast	34.3 nTPM
Lung	29.0 nTPM
Esophagus	28.4 nTPM
Adipose tissue	25.1 nTPM
Skin	23.8 nTPM
Skeletal muscle	23.6 nTPM
Placenta	17.7 nTPM
Stomach	16.3 nTPM
Heart muscle	16.0 nTPM
Ovary	13.9 nTPM

Intestinal goblet cells	11.9 nTPM
Colon	14.3 nTPM
Rectum	10.9 nTPM
Small intestine	10.4 nTPM

Macrophages	23.9 nTPM
Esophagus	51.9 nTPM
Breast	40.0 nTPM
Adipose tissue	32.6 nTPM
PBMC	27.3 nTPM
Skeletal muscle	25.5 nTPM
Spleen	24.9 nTPM
Prostate	24.1 nTPM
Bone marrow	21.2 nTPM
Lung	20.8 nTPM
Endometrium	20.1 nTPM
Ovary	19.3 nTPM
Testis	18.0 nTPM
Stomach	17.6 nTPM
Kidney	8.3 nTPM
Pancreas	7.7 nTPM

Paneth cells	16.9 nTPM
Small intestine	30.0 nTPM
Colon	13.2 nTPM
Rectum	7.3 nTPM

Plasma cells	20.7 nTPM
Adipose tissue	29.1 nTPM
Stomach	24.0 nTPM
Bone marrow	19.8 nTPM
Spleen	18.5 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	10.4 nTPM
Bronchus	12.2 nTPM
Lung	8.7 nTPM

Smooth muscle cells	24.7 nTPM
Endometrium	35.2 nTPM
Breast	35.0 nTPM
Heart muscle	29.9 nTPM
Esophagus	26.4 nTPM
Adipose tissue	25.6 nTPM
Skin	25.5 nTPM
Ovary	25.5 nTPM
Prostate	25.0 nTPM
Skeletal muscle	23.7 nTPM
Pancreas	13.8 nTPM
Bronchus	6.5 nTPM

T-cells	38.3 nTPM
Lymph node	70.8 nTPM
Breast	60.6 nTPM
Ovary	53.4 nTPM
Spleen	42.6 nTPM
Adipose tissue	42.5 nTPM
Bone marrow	42.4 nTPM
Skin	40.1 nTPM
Colon	34.7 nTPM
Skeletal muscle	34.5 nTPM
Stomach	33.6 nTPM
Prostate	33.1 nTPM
Lung	30.4 nTPM
Endometrium	30.0 nTPM
Kidney	29.4 nTPM
PBMC	28.6 nTPM
Liver	25.2 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	24.3 nTPM
Skin	24.3 nTPM

Basal respiratory cells	20.3 nTPM
Bronchus	20.3 nTPM

Basal squamous epithelial cells	43.9 nTPM
Esophagus	43.9 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Undifferentiated cells	11.4 nTPM
Colon	13.6 nTPM
Small intestine	11.4 nTPM
Rectum	9.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC