Single cell type - SBF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SBF2
Gene descriptionⁱ Full gene name according to HGNC.	SET binding factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Microglial cells, Excitatory neurons, Oligodendrocytes, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (non-classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Microglial cells, Excitatory neurons, Oligodendrocytes, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SBF2 is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 0.99
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KCNIP1	Potassium voltage-gated channel interacting protein 1	0.6711	8
MAML3	Mastermind like transcriptional coactivator 3	0.6586	8
POLA1	DNA polymerase alpha 1, catalytic subunit	0.6483	8
MACROD2	Mono-ADP ribosylhydrolase 2	0.6458	8
MTMR7	Myotubularin related protein 7	0.6119	8
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.6058	8
HIVEP3	HIVEP zinc finger 3	0.6024	8
GRPR	Gastrin releasing peptide receptor	0.6006	8
EXT1	Exostosin glycosyltransferase 1	0.5999	8
FAM168A	Family with sequence similarity 168 member A	0.5987	8
EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1	0.5984	8
SLC6A1	Solute carrier family 6 member 1	0.5983	8
TAS2R10	Taste 2 receptor member 10	0.5973	8
CNTNAP5	Contactin associated protein family member 5	0.5962	8
RGS7BP	Regulator of G protein signaling 7 binding protein	0.5931	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.2 nTPM
Adipose tissue	63.0 nTPM
Breast	37.5 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	83.9 nTPM
Lung	83.9 nTPM

B-cells	16.4 nTPM
Spleen	21.8 nTPM
Breast	21.3 nTPM
Stomach	20.9 nTPM
Lymph node	19.3 nTPM
PBMC	18.6 nTPM
Bone marrow	18.0 nTPM
Adipose tissue	16.5 nTPM
Liver	10.6 nTPM
Kidney	9.5 nTPM
Colon	8.0 nTPM

Basal keratinocytes	25.5 nTPM
Skin	25.5 nTPM

Dendritic cells	14.6 nTPM
Breast	21.5 nTPM
Adipose tissue	18.3 nTPM
PBMC	4.0 nTPM

Endothelial cells	40.9 nTPM
Lung	77.9 nTPM
Skeletal muscle	62.7 nTPM
Prostate	58.0 nTPM
Heart muscle	47.0 nTPM
Ovary	38.4 nTPM
Skin	38.0 nTPM
Placenta	36.9 nTPM
Liver	35.7 nTPM
Eye	35.6 nTPM
Esophagus	35.2 nTPM
Breast	33.8 nTPM
Testis	30.8 nTPM
Endometrium	27.0 nTPM
Pancreas	15.5 nTPM

Fibroblasts	40.0 nTPM
Stomach	57.9 nTPM
Adipose tissue	50.9 nTPM
Skeletal muscle	48.1 nTPM
Heart muscle	44.7 nTPM
Lung	42.4 nTPM
Esophagus	40.8 nTPM
Prostate	38.6 nTPM
Skin	35.5 nTPM
Breast	30.4 nTPM
Ovary	28.4 nTPM
Placenta	22.7 nTPM

Intestinal goblet cells	16.2 nTPM
Rectum	19.7 nTPM
Small intestine	18.1 nTPM
Colon	10.7 nTPM

Macrophages	44.8 nTPM
Lung	96.3 nTPM
Spleen	74.6 nTPM
Bone marrow	72.4 nTPM
Adipose tissue	66.1 nTPM
Stomach	52.7 nTPM
Skeletal muscle	51.9 nTPM
Ovary	47.4 nTPM
Esophagus	36.2 nTPM
Prostate	35.5 nTPM
Testis	33.7 nTPM
Kidney	31.8 nTPM
Breast	28.6 nTPM
Pancreas	23.0 nTPM
Endometrium	21.5 nTPM
PBMC	0.0 nTPM

Paneth cells	21.2 nTPM
Small intestine	26.3 nTPM
Rectum	24.1 nTPM
Colon	13.2 nTPM

Plasma cells	9.5 nTPM
Adipose tissue	13.0 nTPM
Spleen	12.0 nTPM
Bone marrow	11.5 nTPM
Esophagus	6.1 nTPM
Stomach	4.9 nTPM

Respiratory ciliated cells	38.3 nTPM
Lung	42.3 nTPM
Bronchus	34.4 nTPM

Smooth muscle cells	34.8 nTPM
Adipose tissue	64.7 nTPM
Skeletal muscle	49.7 nTPM
Prostate	46.9 nTPM
Esophagus	38.8 nTPM
Heart muscle	35.1 nTPM
Ovary	34.1 nTPM
Breast	30.6 nTPM
Skin	29.7 nTPM
Endometrium	28.4 nTPM
Bronchus	16.1 nTPM
Pancreas	8.6 nTPM

T-cells	20.6 nTPM
Liver	51.7 nTPM
Lung	51.6 nTPM
Skeletal muscle	34.5 nTPM
Breast	33.7 nTPM
PBMC	28.7 nTPM
Adipose tissue	19.8 nTPM
Bone marrow	18.5 nTPM
Endometrium	18.2 nTPM
Spleen	16.9 nTPM
Skin	15.7 nTPM
Lymph node	15.0 nTPM
Ovary	13.4 nTPM
Stomach	8.7 nTPM
Kidney	7.5 nTPM
Esophagus	6.6 nTPM
Colon	4.7 nTPM
Prostate	4.7 nTPM

Astrocytes	224.6 nTPM
Brain	224.6 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Cone photoreceptor cells	75.0 nTPM
Eye	75.0 nTPM

Cytotrophoblasts	13.8 nTPM
Placenta	13.8 nTPM

Undifferentiated cells	20.1 nTPM
Rectum	27.0 nTPM
Small intestine	17.9 nTPM
Colon	15.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC