Single cell type - DPF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DPF2
Gene descriptionⁱ Full gene name according to HGNC.	Double PHD fingers 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatogonia & Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DPF2 is part of cluster 20 Spermatogonia & Spermatocytes - Spermatogenesis with confidenceⁱ 1
181 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF559	Zinc finger protein 559	0.5388	52
SYNC	Syncoilin, intermediate filament protein	0.5258	62
TTF1	Transcription termination factor 1	0.5190	6
NHLRC3	NHL repeat containing 3	0.5154	52
ATF6B	Activating transcription factor 6 beta	0.5131	40
YY2	YY2 transcription factor	0.5116	20
RBAK-RBAKDN	RBAK-RBAKDN readthrough	0.5071	20
MAGEB16	MAGE family member B16	0.4994	20
MPHOSPH8	M-phase phosphoprotein 8	0.4942	52
TSPY4	Testis specific protein Y-linked 4	0.4930	20
MED28	Mediator complex subunit 28	0.4908	10
RNASE10	Ribonuclease A family member 10 (inactive)	0.4880	20
RHOXF2	Rhox homeobox family member 2	0.4848	20
PAGE2B	PAGE family member 2B	0.4843	20
MED19	Mediator complex subunit 19	0.4825	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.2 nTPM
Breast	22.6 nTPM
Adipose tissue	15.8 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	10.1 nTPM
Lung	10.1 nTPM

Astrocytes	14.0 nTPM
Brain	14.0 nTPM

B-cells	35.7 nTPM
Kidney	66.6 nTPM
Bone marrow	47.4 nTPM
PBMC	44.2 nTPM
Stomach	34.5 nTPM
Adipose tissue	32.6 nTPM
Spleen	32.2 nTPM
Colon	28.7 nTPM
Breast	25.5 nTPM
Lymph node	22.9 nTPM
Liver	22.8 nTPM

Dendritic cells	42.0 nTPM
Adipose tissue	49.8 nTPM
PBMC	43.8 nTPM
Breast	32.4 nTPM

Endothelial cells	24.2 nTPM
Placenta	33.5 nTPM
Testis	30.8 nTPM
Prostate	29.6 nTPM
Liver	29.3 nTPM
Skin	28.6 nTPM
Pancreas	27.0 nTPM
Eye	24.2 nTPM
Endometrium	23.3 nTPM
Skeletal muscle	22.6 nTPM
Esophagus	22.3 nTPM
Ovary	21.9 nTPM
Breast	20.3 nTPM
Heart muscle	13.4 nTPM
Lung	12.5 nTPM

Fibroblasts	27.2 nTPM
Prostate	41.8 nTPM
Esophagus	36.0 nTPM
Placenta	33.2 nTPM
Breast	30.3 nTPM
Ovary	30.1 nTPM
Skin	27.8 nTPM
Skeletal muscle	25.9 nTPM
Adipose tissue	23.4 nTPM
Stomach	19.3 nTPM
Lung	15.7 nTPM
Heart muscle	15.6 nTPM

Intestinal goblet cells	16.8 nTPM
Small intestine	21.0 nTPM
Rectum	18.6 nTPM
Colon	10.7 nTPM

Macrophages	16.9 nTPM
Kidney	24.9 nTPM
Spleen	22.8 nTPM
Ovary	22.6 nTPM
Testis	20.3 nTPM
Adipose tissue	18.8 nTPM
Breast	18.6 nTPM
Bone marrow	17.5 nTPM
Esophagus	15.8 nTPM
Endometrium	15.7 nTPM
Pancreas	15.3 nTPM
Skeletal muscle	15.2 nTPM
PBMC	13.6 nTPM
Prostate	12.6 nTPM
Lung	11.7 nTPM
Stomach	8.8 nTPM

Paneth cells	8.6 nTPM
Rectum	15.0 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	21.6 nTPM
Adipose tissue	41.9 nTPM
Stomach	20.4 nTPM
Bone marrow	19.8 nTPM
Spleen	19.8 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	19.3 nTPM
Bronchus	31.4 nTPM
Lung	7.3 nTPM

Smooth muscle cells	32.2 nTPM
Bronchus	79.6 nTPM
Skin	33.8 nTPM
Breast	31.6 nTPM
Heart muscle	30.9 nTPM
Ovary	29.7 nTPM
Skeletal muscle	27.2 nTPM
Endometrium	27.1 nTPM
Prostate	26.3 nTPM
Pancreas	25.3 nTPM
Adipose tissue	22.6 nTPM
Esophagus	20.1 nTPM

T-cells	30.6 nTPM
Colon	57.5 nTPM
Prostate	47.3 nTPM
Adipose tissue	43.3 nTPM
Skin	36.8 nTPM
PBMC	36.5 nTPM
Kidney	36.3 nTPM
Liver	34.1 nTPM
Bone marrow	30.3 nTPM
Ovary	28.9 nTPM
Stomach	28.9 nTPM
Breast	28.6 nTPM
Endometrium	26.5 nTPM
Lymph node	22.7 nTPM
Spleen	21.9 nTPM
Skeletal muscle	17.2 nTPM
Esophagus	13.1 nTPM
Lung	10.6 nTPM

Basal prostatic cells	21.8 nTPM
Prostate	21.8 nTPM

Basal respiratory cells	41.7 nTPM
Bronchus	41.7 nTPM

Basal squamous epithelial cells	23.9 nTPM
Esophagus	23.9 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Undifferentiated cells	17.9 nTPM
Small intestine	20.8 nTPM
Rectum	16.8 nTPM
Colon	16.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC