Single cell type - COX16 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COX16
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome c oxidase assembly factor COX16
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal respiratory cells, Ionocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal respiratory cells, Ionocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

COX16 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PGLYRP4	Peptidoglycan recognition protein 4	0.8257	26
SERPINB4	Serpin family B member 4	0.8171	26
SPRR2D	Small proline rich protein 2D	0.8146	26
CCL20	C-C motif chemokine ligand 20	0.8086	26
SERPINB3	Serpin family B member 3	0.8068	26
PI3	Peptidase inhibitor 3	0.8060	26
IL36G	Interleukin 36 gamma	0.8039	26
IL17C	Interleukin 17C	0.8027	26
ATP12A	ATPase H+/K+ transporting non-gastric alpha2 subunit	0.8007	26
NMB	Neuromedin B	0.7983	26
CXCL1	C-X-C motif chemokine ligand 1	0.7967	26
FAM83A	Family with sequence similarity 83 member A	0.7863	26
TMEM45A	Transmembrane protein 45A	0.7843	26
SDR16C5	Short chain dehydrogenase/reductase family 16C member 5	0.7805	26
PORCN	Porcupine O-acyltransferase	0.7762	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.0 nTPM
Adipose tissue	33.1 nTPM
Breast	10.9 nTPM

Alveolar cells type 1	51.3 nTPM
Lung	51.3 nTPM

Alveolar cells type 2	53.9 nTPM
Lung	53.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	45.0 nTPM
Spleen	97.6 nTPM
Stomach	91.3 nTPM
Bone marrow	83.4 nTPM
Lymph node	68.0 nTPM
Liver	35.7 nTPM
Adipose tissue	21.6 nTPM
PBMC	17.1 nTPM
Kidney	14.3 nTPM
Colon	11.2 nTPM
Breast	9.4 nTPM

Dendritic cells	22.9 nTPM
PBMC	35.8 nTPM
Adipose tissue	21.3 nTPM
Breast	11.7 nTPM

Endothelial cells	28.5 nTPM
Skin	102.4 nTPM
Esophagus	66.9 nTPM
Pancreas	42.5 nTPM
Lung	28.1 nTPM
Placenta	26.7 nTPM
Breast	24.5 nTPM
Endometrium	23.6 nTPM
Liver	21.1 nTPM
Testis	20.7 nTPM
Skeletal muscle	14.9 nTPM
Prostate	9.3 nTPM
Ovary	9.2 nTPM
Heart muscle	6.4 nTPM
Eye	3.3 nTPM

Fibroblasts	36.0 nTPM
Skin	98.6 nTPM
Esophagus	75.5 nTPM
Lung	65.9 nTPM
Stomach	59.4 nTPM
Adipose tissue	28.9 nTPM
Breast	23.4 nTPM
Skeletal muscle	15.6 nTPM
Placenta	13.9 nTPM
Heart muscle	5.4 nTPM
Ovary	5.3 nTPM
Prostate	4.6 nTPM

Intestinal goblet cells	35.8 nTPM
Rectum	45.5 nTPM
Small intestine	40.5 nTPM
Colon	21.5 nTPM

Macrophages	40.0 nTPM
Spleen	108.9 nTPM
Lung	84.8 nTPM
Bone marrow	83.7 nTPM
Stomach	79.1 nTPM
Esophagus	75.5 nTPM
Kidney	26.5 nTPM
Endometrium	24.6 nTPM
Pancreas	23.0 nTPM
Testis	20.3 nTPM
Adipose tissue	19.2 nTPM
Skeletal muscle	15.4 nTPM
PBMC	13.6 nTPM
Breast	10.1 nTPM
Prostate	8.1 nTPM
Ovary	7.8 nTPM

Paneth cells	27.0 nTPM
Rectum	44.6 nTPM
Small intestine	26.3 nTPM
Colon	9.9 nTPM

Plasma cells	99.3 nTPM
Stomach	149.4 nTPM
Spleen	145.1 nTPM
Bone marrow	113.8 nTPM
Esophagus	74.0 nTPM
Adipose tissue	14.2 nTPM

Respiratory ciliated cells	137.1 nTPM
Bronchus	189.7 nTPM
Lung	84.5 nTPM

Smooth muscle cells	27.5 nTPM
Bronchus	96.0 nTPM
Skin	54.4 nTPM
Esophagus	48.0 nTPM
Pancreas	38.6 nTPM
Adipose tissue	17.7 nTPM
Endometrium	14.4 nTPM
Skeletal muscle	13.5 nTPM
Breast	6.7 nTPM
Ovary	6.2 nTPM
Prostate	4.1 nTPM
Heart muscle	3.2 nTPM

T-cells	39.8 nTPM
Skin	92.5 nTPM
Spleen	86.6 nTPM
Bone marrow	80.2 nTPM
Stomach	74.9 nTPM
Lymph node	69.2 nTPM
Lung	62.3 nTPM
Esophagus	58.9 nTPM
Liver	25.8 nTPM
Kidney	21.2 nTPM
Endometrium	20.1 nTPM
PBMC	20.0 nTPM
Adipose tissue	18.0 nTPM
Colon	15.7 nTPM
Skeletal muscle	13.4 nTPM
Prostate	9.5 nTPM
Breast	8.7 nTPM
Ovary	0.0 nTPM

Basal keratinocytes	84.4 nTPM
Skin	84.4 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Collecting duct cells	23.9 nTPM
Kidney	23.9 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Undifferentiated cells	39.4 nTPM
Rectum	45.9 nTPM
Small intestine	45.6 nTPM
Colon	26.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC