Single cell type - UBAC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBAC2
Gene descriptionⁱ Full gene name according to HGNC.	UBA domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UBAC2 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM110A	Family with sequence similarity 110 member A	0.6657	51
NRGN	Neurogranin	0.6622	51
MMD	Monocyte to macrophage differentiation associated	0.6566	51
CCND3	Cyclin D3	0.6324	51
MAX	MYC associated factor X	0.6216	51
RGS10	Regulator of G protein signaling 10	0.6206	51
ZGLP1	Zinc finger GATA like protein 1	0.6131	51
RUFY1	RUN and FYVE domain containing 1	0.6108	51
CMTM5	CKLF like MARVEL transmembrane domain containing 5	0.6089	51
RGS18	Regulator of G protein signaling 18	0.6081	51
HBG1	Hemoglobin subunit gamma 1	0.6079	51
ALOX12	Arachidonate 12-lipoxygenase, 12S type	0.6076	51
GRAP2	GRB2 related adaptor protein 2	0.6072	51
GP9	Glycoprotein IX platelet	0.6044	51
LAT	Linker for activation of T cells	0.6040	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	28.7 nTPM
Breast	37.1 nTPM
Adipose tissue	20.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	19.1 nTPM
Lung	19.1 nTPM

Astrocytes	58.8 nTPM
Brain	58.8 nTPM

B-cells	45.3 nTPM
Lymph node	73.8 nTPM
Spleen	72.3 nTPM
Bone marrow	57.2 nTPM
Colon	52.7 nTPM
Stomach	52.6 nTPM
PBMC	44.2 nTPM
Breast	37.5 nTPM
Adipose tissue	26.1 nTPM
Kidney	19.0 nTPM
Liver	17.5 nTPM

Dendritic cells	48.5 nTPM
Breast	69.9 nTPM
PBMC	39.8 nTPM
Adipose tissue	35.8 nTPM

Endothelial cells	26.4 nTPM
Pancreas	38.6 nTPM
Testis	35.3 nTPM
Eye	33.2 nTPM
Breast	29.8 nTPM
Prostate	27.3 nTPM
Esophagus	26.3 nTPM
Ovary	25.7 nTPM
Placenta	25.0 nTPM
Skin	25.0 nTPM
Endometrium	23.3 nTPM
Skeletal muscle	22.6 nTPM
Liver	22.0 nTPM
Heart muscle	19.4 nTPM
Lung	15.6 nTPM

Fibroblasts	31.6 nTPM
Breast	41.0 nTPM
Placenta	38.9 nTPM
Adipose tissue	37.6 nTPM
Ovary	37.0 nTPM
Skin	34.9 nTPM
Esophagus	32.6 nTPM
Prostate	31.3 nTPM
Skeletal muscle	30.1 nTPM
Stomach	28.2 nTPM
Heart muscle	24.5 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	30.1 nTPM
Rectum	34.0 nTPM
Small intestine	28.4 nTPM
Colon	27.9 nTPM

Macrophages	88.4 nTPM
PBMC	450.1 nTPM
Breast	98.0 nTPM
Prostate	90.5 nTPM
Stomach	85.0 nTPM
Skeletal muscle	81.2 nTPM
Endometrium	80.3 nTPM
Adipose tissue	77.2 nTPM
Ovary	68.8 nTPM
Testis	52.3 nTPM
Kidney	49.1 nTPM
Spleen	48.8 nTPM
Esophagus	44.1 nTPM
Bone marrow	38.8 nTPM
Pancreas	35.7 nTPM
Lung	26.5 nTPM

Paneth cells	32.6 nTPM
Rectum	43.6 nTPM
Small intestine	37.6 nTPM
Colon	16.5 nTPM

Plasma cells	11.7 nTPM
Adipose tissue	25.2 nTPM
Bone marrow	14.8 nTPM
Stomach	7.7 nTPM
Esophagus	6.1 nTPM
Spleen	4.8 nTPM

Respiratory ciliated cells	31.6 nTPM
Bronchus	35.5 nTPM
Lung	27.7 nTPM

Smooth muscle cells	32.1 nTPM
Bronchus	78.7 nTPM
Ovary	40.5 nTPM
Skeletal muscle	33.2 nTPM
Pancreas	32.0 nTPM
Breast	29.9 nTPM
Heart muscle	26.5 nTPM
Skin	24.4 nTPM
Prostate	23.7 nTPM
Esophagus	23.3 nTPM
Adipose tissue	21.1 nTPM
Endometrium	19.7 nTPM

T-cells	66.0 nTPM
Stomach	104.2 nTPM
Colon	98.8 nTPM
Lymph node	90.9 nTPM
Spleen	89.5 nTPM
Ovary	86.7 nTPM
Breast	83.7 nTPM
PBMC	74.2 nTPM
Bone marrow	71.2 nTPM
Liver	69.8 nTPM
Esophagus	65.5 nTPM
Kidney	54.0 nTPM
Adipose tissue	49.1 nTPM
Skeletal muscle	48.0 nTPM
Skin	44.7 nTPM
Endometrium	35.1 nTPM
Prostate	33.1 nTPM
Lung	22.8 nTPM

Basal keratinocytes	27.1 nTPM
Skin	27.1 nTPM

Basal prostatic cells	26.0 nTPM
Prostate	26.0 nTPM

Basal respiratory cells	41.7 nTPM
Bronchus	41.7 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	39.1 nTPM
Small intestine	42.2 nTPM
Rectum	40.4 nTPM
Colon	34.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC