Single cell type - PSAT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSAT1
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoserine aminotransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Hepatocytes, Glandular and luminal cells, Basal squamous epithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTCEpi, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Hepatocytes, Glandular and luminal cells, Basal squamous epithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PSAT1 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
WDR72	WD repeat domain 72	0.7820	67
UGT2B7	UDP glucuronosyltransferase family 2 member B7	0.7817	67
SLC22A2	Solute carrier family 22 member 2	0.7161	67
SLC17A3	Solute carrier family 17 member 3	0.7119	67
SLC3A1	Solute carrier family 3 member 1	0.7119	67
SLC22A8	Solute carrier family 22 member 8	0.7103	67
FCAMR	Fc fragment of IgA and IgM receptor	0.7083	67
CLTRN	Collectrin, amino acid transport regulator	0.7081	67
SLC34A1	Solute carrier family 34 member 1	0.7037	67
PTH1R	Parathyroid hormone 1 receptor	0.7015	67
FREM2	FRAS1 related extracellular matrix 2	0.7014	44
NAT8	N-acetyltransferase 8 (putative)	0.7012	67
PRODH2	Proline dehydrogenase 2	0.6989	67
CCDC198	Coiled-coil domain containing 198	0.6985	67
PAX8	Paired box 8	0.6916	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.4 nTPM
Breast	0.5 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	70.2 nTPM
Brain	70.2 nTPM

B-cells	11.0 nTPM
Liver	41.5 nTPM
Kidney	33.4 nTPM
Breast	20.0 nTPM
Spleen	4.9 nTPM
Stomach	2.7 nTPM
Bone marrow	1.7 nTPM
Colon	1.6 nTPM
Adipose tissue	1.5 nTPM
Lymph node	1.5 nTPM
PBMC	1.4 nTPM

Basal squamous epithelial cells	115.5 nTPM
Esophagus	115.5 nTPM

Dendritic cells	2.2 nTPM
Breast	4.3 nTPM
Adipose tissue	2.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	3.7 nTPM
Endometrium	18.0 nTPM
Ovary	10.8 nTPM
Placenta	4.6 nTPM
Pancreas	3.9 nTPM
Liver	3.7 nTPM
Prostate	3.3 nTPM
Testis	2.4 nTPM
Skin	2.3 nTPM
Skeletal muscle	1.0 nTPM
Breast	1.0 nTPM
Heart muscle	0.4 nTPM
Eye	0.0 nTPM
Lung	0.0 nTPM
Esophagus	0.0 nTPM

Fibroblasts	4.2 nTPM
Ovary	23.9 nTPM
Stomach	4.4 nTPM
Placenta	4.2 nTPM
Prostate	2.7 nTPM
Skin	2.6 nTPM
Breast	2.2 nTPM
Heart muscle	1.7 nTPM
Esophagus	1.5 nTPM
Skeletal muscle	1.4 nTPM
Lung	1.2 nTPM
Adipose tissue	0.1 nTPM

Intestinal goblet cells	4.8 nTPM
Colon	6.5 nTPM
Small intestine	6.3 nTPM
Rectum	1.6 nTPM

Macrophages	3.4 nTPM
Kidney	28.0 nTPM
Endometrium	7.2 nTPM
Esophagus	4.8 nTPM
Pancreas	2.5 nTPM
Testis	2.3 nTPM
Skeletal muscle	1.6 nTPM
Prostate	1.2 nTPM
Spleen	1.0 nTPM
Breast	1.0 nTPM
Lung	0.6 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	29.1 nTPM
Spleen	46.7 nTPM
Stomach	35.6 nTPM
Esophagus	30.7 nTPM
Bone marrow	28.0 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	3.8 nTPM
Bronchus	4.6 nTPM
Lung	2.9 nTPM

Smooth muscle cells	14.3 nTPM
Pancreas	141.0 nTPM
Esophagus	4.6 nTPM
Endometrium	3.4 nTPM
Bronchus	2.8 nTPM
Skin	1.4 nTPM
Ovary	1.0 nTPM
Prostate	0.9 nTPM
Breast	0.7 nTPM
Heart muscle	0.6 nTPM
Adipose tissue	0.4 nTPM
Skeletal muscle	0.3 nTPM

Cytotrophoblasts	32.0 nTPM
Placenta	32.0 nTPM

Endometrial stromal cells	10.3 nTPM
Endometrium	10.3 nTPM

Excitatory neurons	7.3 nTPM
Brain	7.3 nTPM

Exocrine glandular cells	48.4 nTPM
Pancreas	48.4 nTPM

T-cells	8.6 nTPM
Kidney	30.2 nTPM
Esophagus	19.7 nTPM
Ovary	15.6 nTPM
Bone marrow	14.0 nTPM
Lymph node	10.0 nTPM
Endometrium	9.3 nTPM
Spleen	8.8 nTPM
Stomach	6.9 nTPM
Liver	6.3 nTPM
Colon	5.2 nTPM
Skin	5.0 nTPM
Prostate	4.7 nTPM
Breast	3.1 nTPM
PBMC	3.0 nTPM
Skeletal muscle	2.3 nTPM
Adipose tissue	1.9 nTPM
Lung	0.0 nTPM

Undifferentiated cells	4.2 nTPM
Small intestine	5.7 nTPM
Colon	5.2 nTPM
Rectum	1.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC