Single cell type - TES - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TES
Gene descriptionⁱ Full gene name according to HGNC.	Testin LIM domain protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Glandular and luminal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (EFO-21, hTCEpi, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Glandular and luminal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TES is part of cluster 41 Macrophages - Immune response with confidenceⁱ 0.99
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRB3	Proline rich protein BstNI subfamily 3	0.6712	29
DDX52	DExD-box helicase 52	0.6113	44
NT5DC4	5'-nucleotidase domain containing 4	0.5687	29
LATS2	Large tumor suppressor kinase 2	0.5639	44
RIPK2	Receptor interacting serine/threonine kinase 2	0.5549	41
ZBTB43	Zinc finger and BTB domain containing 43	0.5431	44
CAST	Calpastatin	0.5344	34
ARL14EPL	ADP ribosylation factor like GTPase 14 effector protein like	0.5305	29
PNPLA8	Patatin like phospholipase domain containing 8	0.5293	41
NOCT	Nocturnin	0.5280	41
NEDD9	Neural precursor cell expressed, developmentally down-regulated 9	0.5243	44
IDO2	Indoleamine 2,3-dioxygenase 2	0.5148	44
ZNF707	Zinc finger protein 707	0.5111	29
CWC25	CWC25 spliceosome associated protein homolog	0.5037	52
TRIM11	Tripartite motif containing 11	0.4933	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.8 nTPM
Adipose tissue	55.9 nTPM
Breast	25.8 nTPM

Alveolar cells type 1	243.6 nTPM
Lung	243.6 nTPM

Alveolar cells type 2	47.0 nTPM
Lung	47.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	60.4 nTPM
Adipose tissue	112.7 nTPM
Colon	68.7 nTPM
PBMC	67.1 nTPM
Lymph node	64.4 nTPM
Bone marrow	63.0 nTPM
Spleen	60.2 nTPM
Liver	59.4 nTPM
Stomach	54.5 nTPM
Kidney	28.5 nTPM
Breast	25.5 nTPM

Dendritic cells	121.3 nTPM
Adipose tissue	245.8 nTPM
Breast	106.1 nTPM
PBMC	12.0 nTPM

Endothelial cells	49.0 nTPM
Endometrium	101.2 nTPM
Esophagus	89.0 nTPM
Skin	76.7 nTPM
Pancreas	65.6 nTPM
Prostate	57.3 nTPM
Breast	54.9 nTPM
Heart muscle	44.6 nTPM
Skeletal muscle	42.9 nTPM
Ovary	38.0 nTPM
Testis	26.1 nTPM
Eye	25.1 nTPM
Placenta	25.0 nTPM
Liver	21.1 nTPM
Lung	18.7 nTPM

Fibroblasts	23.6 nTPM
Skeletal muscle	34.3 nTPM
Stomach	34.1 nTPM
Heart muscle	33.8 nTPM
Skin	32.3 nTPM
Lung	30.1 nTPM
Placenta	26.0 nTPM
Adipose tissue	25.4 nTPM
Prostate	13.3 nTPM
Esophagus	12.5 nTPM
Breast	9.4 nTPM
Ovary	7.9 nTPM

Intestinal goblet cells	100.7 nTPM
Colon	182.2 nTPM
Rectum	60.7 nTPM
Small intestine	59.2 nTPM

Macrophages	78.0 nTPM
Adipose tissue	340.6 nTPM
Stomach	96.7 nTPM
Spleen	88.1 nTPM
Endometrium	86.7 nTPM
Prostate	80.2 nTPM
Bone marrow	76.2 nTPM
Lung	75.6 nTPM
Esophagus	73.9 nTPM
Testis	69.8 nTPM
Kidney	67.3 nTPM
Skeletal muscle	63.8 nTPM
Breast	26.6 nTPM
Ovary	13.9 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	112.1 nTPM
Colon	233.8 nTPM
Rectum	64.8 nTPM
Small intestine	37.6 nTPM

Plasma cells	76.3 nTPM
Adipose tissue	165.1 nTPM
Stomach	57.0 nTPM
Esophagus	55.5 nTPM
Spleen	53.0 nTPM
Bone marrow	51.1 nTPM

Respiratory ciliated cells	68.1 nTPM
Lung	91.9 nTPM
Bronchus	44.5 nTPM

Smooth muscle cells	42.3 nTPM
Bronchus	129.0 nTPM
Ovary	76.8 nTPM
Endometrium	45.5 nTPM
Adipose tissue	45.3 nTPM
Skeletal muscle	39.2 nTPM
Pancreas	37.6 nTPM
Heart muscle	35.1 nTPM
Prostate	23.1 nTPM
Skin	16.0 nTPM
Esophagus	9.3 nTPM
Breast	8.9 nTPM

T-cells	79.2 nTPM
Adipose tissue	166.2 nTPM
Lung	136.7 nTPM
Prostate	127.8 nTPM
PBMC	116.4 nTPM
Endometrium	106.3 nTPM
Bone marrow	99.5 nTPM
Spleen	83.0 nTPM
Liver	76.1 nTPM
Lymph node	69.4 nTPM
Kidney	61.6 nTPM
Stomach	56.1 nTPM
Skeletal muscle	53.5 nTPM
Colon	50.4 nTPM
Esophagus	45.9 nTPM
Breast	38.2 nTPM
Skin	29.9 nTPM
Ovary	28.9 nTPM

Basal keratinocytes	200.4 nTPM
Skin	200.4 nTPM

Basal prostatic cells	196.2 nTPM
Prostate	196.2 nTPM

Basal squamous epithelial cells	60.3 nTPM
Esophagus	60.3 nTPM

Cholangiocytes	47.1 nTPM
Liver	47.1 nTPM

Undifferentiated cells	79.7 nTPM
Colon	141.2 nTPM
Small intestine	51.1 nTPM
Rectum	46.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC