Single cell type - KRT7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KRT7
Gene descriptionⁱ Full gene name according to HGNC.	Keratin 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells, Extravillous trophoblasts, Ductal cells, Prostatic glandular cells, Exocrine glandular cells, Urothelial cells, Cytotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (A549, BEWO, HBEC3-KT, hTERT-HME1, RT4, SiHa, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells, Extravillous trophoblasts, Ductal cells, Prostatic glandular cells, Exocrine glandular cells, Urothelial cells, Cytotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KRT7 is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha	0.7986	16
S100A11	S100 calcium binding protein A11	0.7478	16
KRT18	Keratin 18	0.7361	1
RFLNA	Refilin A	0.7360	16
AL049629.2	Novel protein	0.7335	16
MUCL3	Mucin like 3	0.7239	16
AC008687.4	Novel protein	0.7231	16
HMGA1	High mobility group AT-hook 1	0.7133	16
ANXA3	Annexin A3	0.7125	16
WNT7A	Wnt family member 7A	0.7118	38
JPT1	Jupiter microtubule associated homolog 1	0.7070	7
LAMC2	Laminin subunit gamma 2	0.7044	16
KPNA7	Karyopherin subunit alpha 7	0.6919	16
ANXA10	Annexin A10	0.6725	16
CRCT1	Cysteine rich C-terminal 1	0.6703	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.1 nTPM
Adipose tissue	8.2 nTPM
Breast	7.9 nTPM

Alveolar cells type 1	653.9 nTPM
Lung	653.9 nTPM

Alveolar cells type 2	109.4 nTPM
Lung	109.4 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	2.5 nTPM
Breast	20.0 nTPM
Kidney	4.8 nTPM
Liver	0.4 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	8.9 nTPM
Breast	26.6 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	30.6 nTPM
Prostate	200.6 nTPM
Breast	85.4 nTPM
Placenta	47.7 nTPM
Pancreas	30.9 nTPM
Skeletal muscle	14.8 nTPM
Lung	12.5 nTPM
Skin	11.0 nTPM
Esophagus	10.8 nTPM
Endometrium	7.3 nTPM
Heart muscle	6.0 nTPM
Ovary	1.1 nTPM
Eye	0.0 nTPM
Liver	0.0 nTPM
Testis	0.0 nTPM

Fibroblasts	29.9 nTPM
Prostate	155.0 nTPM
Placenta	107.9 nTPM
Stomach	20.8 nTPM
Breast	19.5 nTPM
Lung	11.1 nTPM
Heart muscle	6.1 nTPM
Skin	6.1 nTPM
Esophagus	0.8 nTPM
Skeletal muscle	0.6 nTPM
Adipose tissue	0.6 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	3.5 nTPM
Colon	5.8 nTPM
Small intestine	3.5 nTPM
Rectum	1.4 nTPM

Macrophages	11.0 nTPM
Prostate	53.9 nTPM
Pancreas	53.7 nTPM
Breast	16.0 nTPM
Endometrium	14.0 nTPM
Lung	10.0 nTPM
Stomach	5.9 nTPM
Skeletal muscle	3.4 nTPM
Kidney	3.0 nTPM
Bone marrow	2.5 nTPM
Esophagus	1.6 nTPM
Adipose tissue	0.7 nTPM
Testis	0.6 nTPM
Ovary	0.3 nTPM
PBMC	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	0.9 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	1.4 nTPM
Esophagus	6.1 nTPM
Stomach	0.9 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	249.2 nTPM
Bronchus	360.0 nTPM
Lung	138.5 nTPM

Smooth muscle cells	72.1 nTPM
Pancreas	340.5 nTPM
Bronchus	267.1 nTPM
Prostate	144.1 nTPM
Breast	13.7 nTPM
Ovary	11.8 nTPM
Endometrium	10.2 nTPM
Skin	4.9 nTPM
Heart muscle	0.6 nTPM
Skeletal muscle	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	9.2 nTPM
Prostate	47.3 nTPM
Breast	29.6 nTPM
Lung	24.3 nTPM
Endometrium	23.7 nTPM
Skin	15.7 nTPM
Kidney	11.6 nTPM
Colon	1.9 nTPM
Liver	0.7 nTPM
Skeletal muscle	0.5 nTPM
Adipose tissue	0.5 nTPM
Bone marrow	0.1 nTPM
Stomach	0.1 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	3.6 nTPM
Skin	3.6 nTPM

Basal prostatic cells	1172.6 nTPM
Prostate	1172.6 nTPM

Basal respiratory cells	173.6 nTPM
Bronchus	173.6 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Undifferentiated cells	4.4 nTPM
Colon	11.7 nTPM
Rectum	0.8 nTPM
Small intestine	0.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC