Single cell type - KLHL36 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KLHL36
Gene descriptionⁱ Full gene name according to HGNC.	Kelch like family member 36
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KLHL36 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARTN	Artemin	0.5585	22
TAF7	TATA-box binding protein associated factor 7	0.5518	22
RNF39	Ring finger protein 39	0.5426	22
MAP2K7	Mitogen-activated protein kinase kinase 7	0.5382	52
ZNF274	Zinc finger protein 274	0.5379	52
GJB4	Gap junction protein beta 4	0.5342	22
KRTAP4-12	Keratin associated protein 4-12	0.5296	22
KRT17	Keratin 17	0.5236	22
LRRC8A	Leucine rich repeat containing 8 VRAC subunit A	0.5233	22
PADI3	Peptidyl arginine deiminase 3	0.5223	22
CLDN4	Claudin 4	0.5212	22
C6orf47	Chromosome 6 open reading frame 47	0.5211	22
RNASE7	Ribonuclease A family member 7	0.5143	22
ZNF836	Zinc finger protein 836	0.5099	22
PHLDA3	Pleckstrin homology like domain family A member 3	0.5097	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.5 nTPM
Adipose tissue	19.6 nTPM
Breast	17.5 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	16.2 nTPM
Lung	16.2 nTPM

Astrocytes	8.5 nTPM
Brain	8.5 nTPM

B-cells	24.6 nTPM
PBMC	38.6 nTPM
Colon	36.7 nTPM
Spleen	25.6 nTPM
Lymph node	24.4 nTPM
Stomach	24.1 nTPM
Breast	24.1 nTPM
Bone marrow	22.1 nTPM
Adipose tissue	19.1 nTPM
Liver	17.1 nTPM
Kidney	14.3 nTPM

Dendritic cells	19.3 nTPM
Breast	24.1 nTPM
Adipose tissue	21.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	19.6 nTPM
Prostate	39.8 nTPM
Eye	34.8 nTPM
Liver	28.4 nTPM
Skin	23.5 nTPM
Skeletal muscle	23.2 nTPM
Breast	20.2 nTPM
Heart muscle	19.7 nTPM
Esophagus	15.5 nTPM
Testis	15.4 nTPM
Endometrium	15.0 nTPM
Ovary	14.8 nTPM
Lung	12.5 nTPM
Placenta	11.9 nTPM
Pancreas	0.0 nTPM

Fibroblasts	20.9 nTPM
Prostate	52.8 nTPM
Skeletal muscle	26.0 nTPM
Adipose tissue	23.5 nTPM
Skin	21.7 nTPM
Ovary	19.0 nTPM
Heart muscle	17.2 nTPM
Esophagus	16.8 nTPM
Breast	16.8 nTPM
Lung	14.5 nTPM
Placenta	12.5 nTPM
Stomach	8.9 nTPM

Intestinal goblet cells	23.3 nTPM
Small intestine	27.4 nTPM
Colon	21.5 nTPM
Rectum	21.0 nTPM

Macrophages	18.0 nTPM
Prostate	43.5 nTPM
Ovary	28.2 nTPM
Breast	20.8 nTPM
Pancreas	20.4 nTPM
Testis	20.3 nTPM
Skeletal muscle	19.4 nTPM
Adipose tissue	18.6 nTPM
Spleen	18.6 nTPM
Stomach	17.6 nTPM
Kidney	16.6 nTPM
Esophagus	14.2 nTPM
Lung	13.7 nTPM
Endometrium	13.7 nTPM
Bone marrow	5.0 nTPM
PBMC	0.0 nTPM

Paneth cells	20.0 nTPM
Rectum	27.2 nTPM
Small intestine	26.3 nTPM
Colon	6.5 nTPM

Plasma cells	10.8 nTPM
Adipose tissue	16.7 nTPM
Esophagus	12.3 nTPM
Spleen	10.4 nTPM
Bone marrow	8.2 nTPM
Stomach	6.3 nTPM

Respiratory ciliated cells	16.3 nTPM
Bronchus	21.0 nTPM
Lung	11.7 nTPM

Smooth muscle cells	24.9 nTPM
Adipose tissue	46.7 nTPM
Prostate	36.9 nTPM
Skeletal muscle	35.3 nTPM
Heart muscle	33.1 nTPM
Breast	23.9 nTPM
Ovary	21.7 nTPM
Skin	20.9 nTPM
Esophagus	18.6 nTPM
Endometrium	17.7 nTPM
Pancreas	14.4 nTPM
Bronchus	4.7 nTPM

T-cells	26.8 nTPM
Ovary	48.9 nTPM
PBMC	40.1 nTPM
Colon	38.0 nTPM
Breast	30.2 nTPM
Adipose tissue	28.5 nTPM
Prostate	28.4 nTPM
Liver	28.2 nTPM
Lymph node	27.6 nTPM
Skeletal muscle	27.1 nTPM
Skin	24.0 nTPM
Spleen	23.5 nTPM
Endometrium	21.9 nTPM
Stomach	20.6 nTPM
Kidney	20.5 nTPM
Bone marrow	19.6 nTPM
Lung	15.2 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	15.9 nTPM
Skin	15.9 nTPM

Basal prostatic cells	45.3 nTPM
Prostate	45.3 nTPM

Basal squamous epithelial cells	15.9 nTPM
Esophagus	15.9 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Undifferentiated cells	21.3 nTPM
Rectum	24.5 nTPM
Small intestine	23.4 nTPM
Colon	16.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC