Single cell type - MPHOSPH6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPHOSPH6
Gene descriptionⁱ Full gene name according to HGNC.	M-phase phosphoprotein 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPHOSPH6 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CYP24A1	Cytochrome P450 family 24 subfamily A member 1	0.6126	26
KYNU	Kynureninase	0.5987	26
CXCL3	C-X-C motif chemokine ligand 3	0.5839	26
ADORA2B	Adenosine A2b receptor	0.5785	26
PGK1	Phosphoglycerate kinase 1	0.5759	26
PTHLH	Parathyroid hormone like hormone	0.5750	26
SERPINB4	Serpin family B member 4	0.5697	26
CCL20	C-C motif chemokine ligand 20	0.5650	26
ATP12A	ATPase H+/K+ transporting non-gastric alpha2 subunit	0.5556	26
IL36G	Interleukin 36 gamma	0.5498	26
SPRR2D	Small proline rich protein 2D	0.5480	26
FAM83A	Family with sequence similarity 83 member A	0.5429	26
VMO1	Vitelline membrane outer layer 1 homolog	0.5404	26
MRGPRX3	MAS related GPR family member X3	0.5402	26
NMB	Neuromedin B	0.5395	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.2 nTPM
Adipose tissue	13.2 nTPM
Breast	13.2 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	38.3 nTPM
Lung	38.3 nTPM

Astrocytes	20.5 nTPM
Brain	20.5 nTPM

B-cells	22.9 nTPM
Liver	42.3 nTPM
Colon	30.3 nTPM
Spleen	26.9 nTPM
Kidney	23.8 nTPM
PBMC	21.4 nTPM
Stomach	18.6 nTPM
Lymph node	17.5 nTPM
Bone marrow	17.2 nTPM
Adipose tissue	15.6 nTPM
Breast	14.7 nTPM

Dendritic cells	23.0 nTPM
Breast	25.5 nTPM
Adipose tissue	23.5 nTPM
PBMC	20.0 nTPM

Endothelial cells	19.3 nTPM
Lung	40.6 nTPM
Placenta	39.3 nTPM
Heart muscle	29.6 nTPM
Breast	18.9 nTPM
Skin	18.6 nTPM
Ovary	17.4 nTPM
Pancreas	15.5 nTPM
Skeletal muscle	14.9 nTPM
Prostate	14.8 nTPM
Testis	14.2 nTPM
Endometrium	13.3 nTPM
Liver	11.9 nTPM
Esophagus	10.8 nTPM
Eye	10.5 nTPM

Fibroblasts	31.4 nTPM
Placenta	85.9 nTPM
Lung	61.4 nTPM
Heart muscle	42.6 nTPM
Ovary	24.2 nTPM
Stomach	23.7 nTPM
Skin	19.9 nTPM
Adipose tissue	19.7 nTPM
Breast	19.5 nTPM
Esophagus	16.9 nTPM
Prostate	16.7 nTPM
Skeletal muscle	15.2 nTPM

Intestinal goblet cells	20.7 nTPM
Small intestine	28.9 nTPM
Rectum	18.2 nTPM
Colon	15.0 nTPM

Macrophages	55.9 nTPM
Adipose tissue	156.1 nTPM
Lung	126.2 nTPM
Pancreas	120.0 nTPM
Kidney	70.4 nTPM
Stomach	64.5 nTPM
Prostate	55.1 nTPM
Skeletal muscle	39.6 nTPM
Spleen	34.2 nTPM
Testis	33.1 nTPM
Endometrium	28.4 nTPM
Bone marrow	27.5 nTPM
Ovary	27.2 nTPM
Breast	24.1 nTPM
Esophagus	18.9 nTPM
PBMC	13.6 nTPM

Paneth cells	28.4 nTPM
Colon	32.9 nTPM
Small intestine	30.0 nTPM
Rectum	22.4 nTPM

Plasma cells	22.3 nTPM
Spleen	33.8 nTPM
Bone marrow	31.3 nTPM
Esophagus	24.6 nTPM
Stomach	12.0 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	32.7 nTPM
Lung	37.9 nTPM
Bronchus	27.5 nTPM

Smooth muscle cells	30.1 nTPM
Heart muscle	77.7 nTPM
Pancreas	62.5 nTPM
Bronchus	37.6 nTPM
Skin	26.2 nTPM
Ovary	22.5 nTPM
Esophagus	21.7 nTPM
Skeletal muscle	19.6 nTPM
Adipose tissue	17.0 nTPM
Prostate	16.8 nTPM
Breast	15.0 nTPM
Endometrium	14.0 nTPM

T-cells	27.4 nTPM
Lung	45.6 nTPM
Kidney	43.8 nTPM
PBMC	38.2 nTPM
Stomach	31.4 nTPM
Ovary	28.9 nTPM
Liver	28.3 nTPM
Breast	28.0 nTPM
Lymph node	26.8 nTPM
Colon	25.6 nTPM
Skin	25.4 nTPM
Adipose tissue	25.4 nTPM
Spleen	24.9 nTPM
Bone marrow	23.1 nTPM
Skeletal muscle	21.4 nTPM
Endometrium	19.9 nTPM
Esophagus	19.7 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	38.7 nTPM
Skin	38.7 nTPM

Basal prostatic cells	40.3 nTPM
Prostate	40.3 nTPM

Basal respiratory cells	123.9 nTPM
Bronchus	123.9 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Undifferentiated cells	34.0 nTPM
Colon	40.0 nTPM
Small intestine	35.1 nTPM
Rectum	27.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC