Single cell type - GCC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GCC2
Gene descriptionⁱ Full gene name according to HGNC.	GRIP and coiled-coil domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GCC2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANKZF1	Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1	0.5602	52
ZNF764	Zinc finger protein 764	0.5515	24
TUBGCP2	Tubulin gamma complex associated protein 2	0.5511	49
ODF2L	Outer dense fiber of sperm tails 2 like	0.5385	49
N4BP2L2	NEDD4 binding protein 2 like 2	0.5225	52
SP140L	SP140 nuclear body protein like	0.5143	7
MIA3	MIA SH3 domain ER export factor 3	0.5143	52
SCAF11	SR-related CTD associated factor 11	0.5105	52
POLR2B	RNA polymerase II subunit B	0.5088	52
ZNF33A	Zinc finger protein 33A	0.5082	52
RCAN3	RCAN family member 3	0.4951	24
CASP8	Caspase 8	0.4856	24
SLC25A45	Solute carrier family 25 member 45	0.4803	63
SYF2	SYF2 pre-mRNA splicing factor	0.4782	63
PIK3IP1	Phosphoinositide-3-kinase interacting protein 1	0.4769	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	92.6 nTPM
Adipose tissue	96.8 nTPM
Breast	88.4 nTPM

Alveolar cells type 1	150.6 nTPM
Lung	150.6 nTPM

Alveolar cells type 2	103.3 nTPM
Lung	103.3 nTPM

Astrocytes	44.1 nTPM
Brain	44.1 nTPM

B-cells	125.2 nTPM
Adipose tissue	259.2 nTPM
PBMC	178.5 nTPM
Colon	166.1 nTPM
Stomach	147.2 nTPM
Bone marrow	102.2 nTPM
Lymph node	90.5 nTPM
Kidney	90.4 nTPM
Spleen	89.0 nTPM
Breast	72.2 nTPM
Liver	56.3 nTPM

Dendritic cells	157.6 nTPM
Adipose tissue	243.7 nTPM
PBMC	131.5 nTPM
Breast	97.7 nTPM

Endothelial cells	68.1 nTPM
Heart muscle	126.6 nTPM
Eye	115.7 nTPM
Testis	85.9 nTPM
Ovary	85.9 nTPM
Liver	78.0 nTPM
Skeletal muscle	76.3 nTPM
Endometrium	64.0 nTPM
Lung	56.1 nTPM
Breast	54.1 nTPM
Pancreas	54.0 nTPM
Esophagus	49.5 nTPM
Prostate	43.2 nTPM
Placenta	31.8 nTPM
Skin	31.7 nTPM

Fibroblasts	74.2 nTPM
Heart muscle	138.7 nTPM
Lung	134.0 nTPM
Adipose tissue	95.4 nTPM
Skeletal muscle	74.0 nTPM
Breast	71.9 nTPM
Prostate	70.9 nTPM
Ovary	56.3 nTPM
Stomach	52.0 nTPM
Esophagus	50.4 nTPM
Placenta	39.9 nTPM
Skin	32.4 nTPM

Intestinal goblet cells	152.6 nTPM
Colon	177.3 nTPM
Small intestine	145.7 nTPM
Rectum	134.7 nTPM

Macrophages	66.0 nTPM
Lung	149.5 nTPM
Ovary	104.2 nTPM
Adipose tissue	101.0 nTPM
Breast	86.7 nTPM
Skeletal muscle	74.2 nTPM
Testis	69.2 nTPM
Endometrium	63.2 nTPM
Kidney	56.0 nTPM
Esophagus	55.1 nTPM
Bone marrow	52.4 nTPM
Prostate	50.4 nTPM
Stomach	41.0 nTPM
Spleen	37.4 nTPM
Pancreas	35.7 nTPM
PBMC	13.6 nTPM

Paneth cells	125.2 nTPM
Colon	151.5 nTPM
Small intestine	120.2 nTPM
Rectum	103.9 nTPM

Plasma cells	108.7 nTPM
Adipose tissue	301.3 nTPM
Stomach	95.2 nTPM
Esophagus	55.5 nTPM
Spleen	54.9 nTPM
Bone marrow	36.2 nTPM

Respiratory ciliated cells	259.7 nTPM
Lung	332.3 nTPM
Bronchus	187.1 nTPM

Smooth muscle cells	66.2 nTPM
Heart muscle	130.5 nTPM
Adipose tissue	100.3 nTPM
Skeletal muscle	88.7 nTPM
Ovary	87.3 nTPM
Breast	61.9 nTPM
Endometrium	61.5 nTPM
Esophagus	48.0 nTPM
Pancreas	45.9 nTPM
Prostate	40.0 nTPM
Skin	33.1 nTPM
Bronchus	31.3 nTPM

T-cells	139.1 nTPM
Adipose tissue	287.7 nTPM
PBMC	273.4 nTPM
Skeletal muscle	170.4 nTPM
Lung	162.5 nTPM
Colon	154.9 nTPM
Ovary	144.6 nTPM
Kidney	141.0 nTPM
Breast	134.3 nTPM
Lymph node	134.1 nTPM
Endometrium	130.3 nTPM
Prostate	118.3 nTPM
Bone marrow	115.1 nTPM
Spleen	115.1 nTPM
Stomach	109.7 nTPM
Liver	81.9 nTPM
Skin	71.8 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	23.8 nTPM
Skin	23.8 nTPM

Basal prostatic cells	68.6 nTPM
Prostate	68.6 nTPM

Basal respiratory cells	54.8 nTPM
Bronchus	54.8 nTPM

Basal squamous epithelial cells	29.6 nTPM
Esophagus	29.6 nTPM

Undifferentiated cells	88.3 nTPM
Colon	115.2 nTPM
Rectum	78.7 nTPM
Small intestine	71.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC