Single cell type - DRAM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DRAM1
Gene descriptionⁱ Full gene name according to HGNC.	DNA damage regulated autophagy modulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Alveolar cells - Smell perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 2, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (BJ hTERT+)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 2, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DRAM1 is part of cluster 11 Alveolar cells - Smell perception with confidenceⁱ 1
281 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SFTPD	Surfactant protein D	0.6565	11
AGTR2	Angiotensin II receptor type 2	0.6544	11
SLC22A31	Solute carrier family 22 member 31	0.6537	11
SFTPA1	Surfactant protein A1	0.6529	11
SFTPA2	Surfactant protein A2	0.6502	11
NAPSA	Napsin A aspartic peptidase	0.6483	11
SFTPC	Surfactant protein C	0.6469	11
AL592490.1	Novel protein	0.6440	11
VEPH1	Ventricular zone expressed PH domain containing 1	0.6425	11
SFTPB	Surfactant protein B	0.6419	11
SERTM2	Serine rich and transmembrane domain containing 2	0.6403	11
AL132671.2	Novel protein, GOPC-ROS1 readthrough	0.6366	11
OR51M1	Olfactory receptor family 51 subfamily M member 1	0.6297	11
MS4A15	Membrane spanning 4-domains A15	0.6255	11
NKX2-1	NK2 homeobox 1	0.6178	11

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.2 nTPM
Adipose tissue	18.6 nTPM
Breast	15.8 nTPM

Alveolar cells type 1	54.5 nTPM
Lung	54.5 nTPM

Astrocytes	4.9 nTPM
Brain	4.9 nTPM

B-cells	10.7 nTPM
Colon	25.5 nTPM
Liver	19.4 nTPM
Stomach	16.4 nTPM
Lymph node	11.8 nTPM
Spleen	10.0 nTPM
Adipose tissue	9.6 nTPM
PBMC	5.7 nTPM
Bone marrow	4.9 nTPM
Breast	4.0 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	20.9 nTPM
Skin	20.9 nTPM

Dendritic cells	5.0 nTPM
Adipose tissue	10.7 nTPM
Breast	4.3 nTPM
PBMC	0.0 nTPM

Endothelial cells	16.5 nTPM
Prostate	25.7 nTPM
Esophagus	22.7 nTPM
Skeletal muscle	21.9 nTPM
Pancreas	19.3 nTPM
Endometrium	19.0 nTPM
Placenta	18.8 nTPM
Heart muscle	18.1 nTPM
Skin	16.8 nTPM
Eye	16.2 nTPM
Lung	15.6 nTPM
Breast	11.2 nTPM
Ovary	10.9 nTPM
Liver	9.2 nTPM
Testis	5.9 nTPM

Fibroblasts	30.5 nTPM
Prostate	81.3 nTPM
Stomach	40.1 nTPM
Skin	37.0 nTPM
Skeletal muscle	28.2 nTPM
Adipose tissue	28.1 nTPM
Lung	27.9 nTPM
Esophagus	26.8 nTPM
Placenta	19.2 nTPM
Breast	18.6 nTPM
Ovary	17.1 nTPM
Heart muscle	10.8 nTPM

Intestinal goblet cells	1.6 nTPM
Rectum	3.7 nTPM
Colon	0.7 nTPM
Small intestine	0.4 nTPM

Macrophages	51.9 nTPM
Prostate	122.7 nTPM
Pancreas	112.3 nTPM
Stomach	79.1 nTPM
Spleen	62.2 nTPM
Bone marrow	53.7 nTPM
Kidney	50.6 nTPM
Endometrium	48.5 nTPM
Adipose tissue	48.2 nTPM
Lung	45.0 nTPM
Testis	40.1 nTPM
Skeletal muscle	27.8 nTPM
PBMC	27.3 nTPM
Ovary	23.9 nTPM
Esophagus	20.4 nTPM
Breast	16.5 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	30.9 nTPM
Spleen	51.3 nTPM
Bone marrow	39.5 nTPM
Stomach	37.7 nTPM
Adipose tissue	13.6 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	7.4 nTPM
Bronchus	7.4 nTPM
Lung	7.3 nTPM

Smooth muscle cells	9.9 nTPM
Pancreas	37.9 nTPM
Endometrium	11.9 nTPM
Ovary	11.5 nTPM
Esophagus	10.9 nTPM
Prostate	9.1 nTPM
Skin	8.3 nTPM
Skeletal muscle	7.7 nTPM
Adipose tissue	4.3 nTPM
Breast	4.1 nTPM
Heart muscle	2.4 nTPM
Bronchus	1.0 nTPM

T-cells	6.4 nTPM
Lung	16.7 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM
Skin	7.8 nTPM
Colon	7.1 nTPM
Endometrium	7.0 nTPM
Adipose tissue	6.1 nTPM
Spleen	5.5 nTPM
Lymph node	5.3 nTPM
Stomach	5.3 nTPM
Ovary	4.5 nTPM
Skeletal muscle	4.4 nTPM
Breast	4.2 nTPM
Bone marrow	4.1 nTPM
Kidney	3.4 nTPM
Liver	2.8 nTPM
PBMC	2.2 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Distal enterocytes	1.3 nTPM
Colon	1.3 nTPM
Rectum	1.3 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Endometrial stromal cells	30.8 nTPM
Endometrium	30.8 nTPM

Undifferentiated cells	1.2 nTPM
Colon	1.9 nTPM
Rectum	1.2 nTPM
Small intestine	0.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC