Single cell type - ITM2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITM2B
Gene descriptionⁱ Full gene name according to HGNC.	Integral membrane protein 2B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HMC-1, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ITM2B is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLN5	CLN5 intracellular trafficking protein	0.6256	26
A4GALT	Alpha 1,4-galactosyltransferase (P blood group)	0.6041	50
LAMP2	Lysosomal associated membrane protein 2	0.5734	26
LAPTM4A	Lysosomal protein transmembrane 4 alpha	0.5580	26
LEPROT	Leptin receptor overlapping transcript	0.5372	14
LBX2	Ladybird homeobox 2	0.5345	67
P4HA1	Prolyl 4-hydroxylase subunit alpha 1	0.5203	26
GPX3	Glutathione peroxidase 3	0.4953	67
RRAGA	Ras related GTP binding A	0.4942	26
UGT2B7	UDP glucuronosyltransferase family 2 member B7	0.4923	67
WDR72	WD repeat domain 72	0.4899	67
TNFSF10	TNF superfamily member 10	0.4896	67
C1GALT1C1	C1GALT1 specific chaperone 1	0.4881	26
SCPEP1	Serine carboxypeptidase 1	0.4881	26
OR6C6	Olfactory receptor family 6 subfamily C member 6	0.4871	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1380.0 nTPM
Adipose tissue	1523.7 nTPM
Breast	1236.3 nTPM

Alveolar cells type 1	695.5 nTPM
Lung	695.5 nTPM

Alveolar cells type 2	300.4 nTPM
Lung	300.4 nTPM

Astrocytes	174.6 nTPM
Brain	174.6 nTPM

B-cells	408.6 nTPM
Kidney	642.8 nTPM
Adipose tissue	482.7 nTPM
Breast	421.3 nTPM
PBMC	405.4 nTPM
Stomach	391.5 nTPM
Lymph node	377.3 nTPM
Spleen	362.7 nTPM
Liver	353.7 nTPM
Bone marrow	335.2 nTPM
Colon	313.1 nTPM

Basal squamous epithelial cells	1006.2 nTPM
Esophagus	1006.2 nTPM

Dendritic cells	448.2 nTPM
Adipose tissue	628.0 nTPM
Breast	545.2 nTPM
PBMC	171.4 nTPM

Distal enterocytes	754.2 nTPM
Rectum	1031.2 nTPM
Colon	477.3 nTPM

Endothelial cells	1166.2 nTPM
Esophagus	1980.3 nTPM
Placenta	1830.9 nTPM
Eye	1538.2 nTPM
Prostate	1452.3 nTPM
Skeletal muscle	1351.4 nTPM
Breast	1139.1 nTPM
Skin	1127.2 nTPM
Liver	1073.1 nTPM
Testis	1036.2 nTPM
Pancreas	849.4 nTPM
Heart muscle	807.6 nTPM
Endometrium	753.7 nTPM
Lung	701.8 nTPM
Ovary	685.5 nTPM

Enteroendocrine cells	283.3 nTPM
Colon	294.9 nTPM
Rectum	271.8 nTPM

Erythroid cells	307.0 nTPM
Liver	422.4 nTPM
Bone marrow	191.7 nTPM

Fibroblasts	1334.0 nTPM
Adipose tissue	2832.1 nTPM
Stomach	1868.0 nTPM
Prostate	1802.4 nTPM
Skeletal muscle	1512.0 nTPM
Esophagus	1482.8 nTPM
Breast	1424.9 nTPM
Skin	1038.6 nTPM
Heart muscle	919.2 nTPM
Placenta	690.2 nTPM
Lung	617.8 nTPM
Ovary	486.1 nTPM

Glandular and luminal cells	1177.2 nTPM
Endometrium	1177.2 nTPM

Intestinal goblet cells	503.2 nTPM
Small intestine	520.3 nTPM
Colon	503.1 nTPM
Rectum	486.0 nTPM

Macrophages	1381.5 nTPM
Adipose tissue	1890.8 nTPM
Breast	1823.8 nTPM
Testis	1795.7 nTPM
Esophagus	1732.5 nTPM
Spleen	1651.7 nTPM
Prostate	1641.6 nTPM
Ovary	1622.1 nTPM
Stomach	1295.2 nTPM
Kidney	1269.7 nTPM
PBMC	1241.3 nTPM
Bone marrow	1212.1 nTPM
Skeletal muscle	1020.8 nTPM
Pancreas	990.3 nTPM
Endometrium	907.8 nTPM
Lung	627.1 nTPM

Cholangiocytes	722.0 nTPM
Liver	722.0 nTPM

Collecting duct cells	1991.8 nTPM
Kidney	1991.8 nTPM

Cone photoreceptor cells	187.7 nTPM
Eye	187.7 nTPM

Cytotrophoblasts	1164.3 nTPM
Placenta	1164.3 nTPM

Paneth cells	788.3 nTPM
Small intestine	968.6 nTPM
Colon	823.4 nTPM
Rectum	572.9 nTPM

Plasma cells	445.4 nTPM
Esophagus	640.6 nTPM
Adipose tissue	446.4 nTPM
Spleen	419.7 nTPM
Stomach	414.0 nTPM
Bone marrow	306.5 nTPM

Respiratory ciliated cells	795.6 nTPM
Bronchus	1336.2 nTPM
Lung	255.1 nTPM

Smooth muscle cells	1022.9 nTPM
Bronchus	2475.0 nTPM
Esophagus	1260.6 nTPM
Skeletal muscle	1237.0 nTPM
Adipose tissue	1143.8 nTPM
Prostate	970.5 nTPM
Ovary	863.7 nTPM
Breast	862.6 nTPM
Endometrium	752.0 nTPM
Skin	627.1 nTPM
Heart muscle	607.3 nTPM
Pancreas	451.8 nTPM

T-cells	723.2 nTPM
Kidney	1045.9 nTPM
Ovary	987.7 nTPM
Adipose tissue	912.2 nTPM
Lymph node	852.7 nTPM
Stomach	841.2 nTPM
Skin	796.2 nTPM
Skeletal muscle	793.6 nTPM
Spleen	782.6 nTPM
Breast	753.2 nTPM
Prostate	724.2 nTPM
Bone marrow	719.1 nTPM
PBMC	654.1 nTPM
Liver	589.9 nTPM
Endometrium	573.6 nTPM
Colon	519.4 nTPM
Esophagus	445.4 nTPM
Lung	303.7 nTPM

Undifferentiated cells	440.9 nTPM
Small intestine	482.3 nTPM
Colon	424.3 nTPM
Rectum	416.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC