Single cell type - GYPC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GYPC
Gene descriptionⁱ Full gene name according to HGNC.	Glycophorin C (Gerbich blood group)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Blood group antigen proteins CD markers
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HHSteC, K-562, SK-MEL-30, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GYPC is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 1
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor	0.7483	6
HBA2	Hemoglobin subunit alpha 2	0.7397	6
HBA1	Hemoglobin subunit alpha 1	0.7387	6
HBB	Hemoglobin subunit beta	0.7386	6
IFIT1B	Interferon induced protein with tetratricopeptide repeats 1B	0.7375	6
HBD	Hemoglobin subunit delta	0.7365	6
ALAS2	5'-aminolevulinate synthase 2	0.7354	6
TSPO2	Translocator protein 2	0.7350	6
RHCE	Rh blood group CcEe antigens	0.7329	6
HBM	Hemoglobin subunit mu	0.7306	6
GYPA	Glycophorin A (MNS blood group)	0.7305	6
AHSP	Alpha hemoglobin stabilizing protein	0.7302	6
EPB42	Erythrocyte membrane protein band 4.2	0.7298	6
SLC4A1	Solute carrier family 4 member 1 (Diego blood group)	0.7287	6
GYPB	Glycophorin B (MNS blood group)	0.7265	6

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	260.7 nTPM
Adipose tissue	298.1 nTPM
Breast	223.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	7.7 nTPM
Lung	7.7 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

B-cells	152.7 nTPM
Liver	243.2 nTPM
PBMC	201.3 nTPM
Colon	185.3 nTPM
Adipose tissue	163.9 nTPM
Breast	156.5 nTPM
Spleen	140.5 nTPM
Kidney	128.5 nTPM
Stomach	114.0 nTPM
Lymph node	99.7 nTPM
Bone marrow	94.0 nTPM

Dendritic cells	194.0 nTPM
Adipose tissue	358.6 nTPM
Breast	215.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	157.2 nTPM
Ovary	420.7 nTPM
Pancreas	270.2 nTPM
Prostate	242.5 nTPM
Liver	242.2 nTPM
Skeletal muscle	219.9 nTPM
Breast	177.7 nTPM
Skin	137.4 nTPM
Placenta	101.8 nTPM
Eye	80.1 nTPM
Lung	77.9 nTPM
Testis	70.6 nTPM
Esophagus	65.9 nTPM
Heart muscle	48.2 nTPM
Endometrium	45.7 nTPM

Erythroid cells	1728.6 nTPM
Liver	2973.7 nTPM
Bone marrow	483.4 nTPM

Fibroblasts	170.5 nTPM
Prostate	406.7 nTPM
Adipose tissue	292.3 nTPM
Ovary	192.2 nTPM
Skin	191.4 nTPM
Esophagus	188.0 nTPM
Placenta	174.3 nTPM
Skeletal muscle	168.4 nTPM
Breast	139.3 nTPM
Stomach	75.7 nTPM
Lung	29.0 nTPM
Heart muscle	18.5 nTPM

Intestinal goblet cells	1.1 nTPM
Colon	2.9 nTPM
Rectum	0.3 nTPM
Small intestine	0.0 nTPM

Macrophages	134.9 nTPM
Ovary	704.3 nTPM
Adipose tissue	182.7 nTPM
Esophagus	160.5 nTPM
Prostate	149.0 nTPM
Skeletal muscle	131.0 nTPM
Breast	114.7 nTPM
Pancreas	99.5 nTPM
Kidney	87.0 nTPM
Stomach	79.1 nTPM
Lung	67.3 nTPM
Testis	65.0 nTPM
Bone marrow	61.2 nTPM
Spleen	60.2 nTPM
Endometrium	48.1 nTPM
PBMC	13.6 nTPM

Paneth cells	0.4 nTPM
Rectum	1.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	250.9 nTPM
Stomach	356.0 nTPM
Spleen	260.4 nTPM
Esophagus	221.7 nTPM
Bone marrow	215.9 nTPM
Adipose tissue	200.6 nTPM

Respiratory ciliated cells	1.7 nTPM
Lung	2.9 nTPM
Bronchus	0.5 nTPM

Smooth muscle cells	88.6 nTPM
Pancreas	197.3 nTPM
Prostate	141.0 nTPM
Breast	125.6 nTPM
Adipose tissue	122.0 nTPM
Skin	101.4 nTPM
Skeletal muscle	94.1 nTPM
Ovary	86.0 nTPM
Esophagus	46.5 nTPM
Endometrium	36.6 nTPM
Heart muscle	23.9 nTPM
Bronchus	0.0 nTPM

Basal keratinocytes	38.0 nTPM
Skin	38.0 nTPM

Basal prostatic cells	3.4 nTPM
Prostate	3.4 nTPM

Basal respiratory cells	17.0 nTPM
Bronchus	17.0 nTPM

Basal squamous epithelial cells	43.3 nTPM
Esophagus	43.3 nTPM

T-cells	228.0 nTPM
Adipose tissue	379.3 nTPM
PBMC	332.2 nTPM
Liver	331.9 nTPM
Ovary	289.2 nTPM
Stomach	264.0 nTPM
Skin	260.7 nTPM
Kidney	253.2 nTPM
Colon	250.9 nTPM
Lymph node	235.8 nTPM
Spleen	217.2 nTPM
Esophagus	196.5 nTPM
Bone marrow	194.2 nTPM
Breast	179.7 nTPM
Skeletal muscle	163.7 nTPM
Prostate	137.3 nTPM
Endometrium	124.4 nTPM
Lung	65.3 nTPM

Undifferentiated cells	1.6 nTPM
Colon	4.6 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC