Single cell type - DNAJC1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNAJC1
Gene descriptionⁱ Full gene name according to HGNC.	DnaJ heat shock protein family (Hsp40) member C1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes & Spermatogonia - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DNAJC1 is part of cluster 13 Spermatocytes & Spermatogonia - Spermatogenesis with confidenceⁱ 1
231 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLSPN	Claspin	0.5314	13
RNF34	Ring finger protein 34	0.5228	13
DPH7	Diphthamide biosynthesis 7	0.5200	13
PIGK	Phosphatidylinositol glycan anchor biosynthesis class K	0.5110	13
PXT1	Peroxisomal testis enriched protein 1	0.4980	13
XRN1	5'-3' exoribonuclease 1	0.4965	59
HESX1	HESX homeobox 1	0.4711	13
S100PBP	S100P binding protein	0.4654	13
ARIH2	Ariadne RBR E3 ubiquitin protein ligase 2	0.4652	13
PCGF6	Polycomb group ring finger 6	0.4586	13
SRBD1	S1 RNA binding domain 1	0.4568	52
KRIT1	KRIT1 ankyrin repeat containing	0.4565	13
MTBP	MDM2 binding protein	0.4541	12
FBXO47	F-box protein 47	0.4510	13
CCDC73	Coiled-coil domain containing 73	0.4465	13

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	56.4 nTPM
Breast	64.0 nTPM
Adipose tissue	48.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	26.9 nTPM
Lung	26.9 nTPM

Astrocytes	73.4 nTPM
Brain	73.4 nTPM

B-cells	46.7 nTPM
Liver	142.5 nTPM
Breast	125.8 nTPM
PBMC	37.1 nTPM
Colon	30.3 nTPM
Adipose tissue	30.0 nTPM
Spleen	29.7 nTPM
Stomach	25.0 nTPM
Lymph node	22.7 nTPM
Bone marrow	18.8 nTPM
Kidney	4.8 nTPM

Dendritic cells	92.9 nTPM
Breast	109.7 nTPM
Adipose tissue	105.2 nTPM
PBMC	63.8 nTPM

Endothelial cells	54.7 nTPM
Prostate	89.5 nTPM
Eye	76.1 nTPM
Liver	76.1 nTPM
Ovary	60.2 nTPM
Testis	53.3 nTPM
Esophagus	53.3 nTPM
Skeletal muscle	52.3 nTPM
Endometrium	51.1 nTPM
Pancreas	50.2 nTPM
Skin	49.6 nTPM
Breast	49.4 nTPM
Placenta	45.5 nTPM
Heart muscle	33.8 nTPM
Lung	24.9 nTPM

Fibroblasts	67.4 nTPM
Prostate	167.6 nTPM
Placenta	97.5 nTPM
Skeletal muscle	87.6 nTPM
Adipose tissue	65.5 nTPM
Skin	64.1 nTPM
Stomach	57.9 nTPM
Breast	52.6 nTPM
Esophagus	51.5 nTPM
Heart muscle	44.0 nTPM
Ovary	37.9 nTPM
Lung	14.5 nTPM

Intestinal goblet cells	75.8 nTPM
Colon	103.7 nTPM
Small intestine	72.4 nTPM
Rectum	51.4 nTPM

Macrophages	44.2 nTPM
Ovary	70.9 nTPM
Prostate	62.0 nTPM
Adipose tissue	57.8 nTPM
Stomach	52.7 nTPM
Skeletal muscle	52.6 nTPM
Kidney	52.2 nTPM
Breast	49.9 nTPM
Endometrium	46.5 nTPM
Esophagus	42.5 nTPM
Bone marrow	36.3 nTPM
Testis	36.0 nTPM
Pancreas	33.2 nTPM
Spleen	32.1 nTPM
Lung	25.1 nTPM
PBMC	13.6 nTPM

Paneth cells	49.2 nTPM
Colon	62.6 nTPM
Rectum	51.3 nTPM
Small intestine	33.8 nTPM

Plasma cells	202.7 nTPM
Stomach	318.8 nTPM
Esophagus	233.9 nTPM
Spleen	198.5 nTPM
Bone marrow	141.8 nTPM
Adipose tissue	120.6 nTPM

Respiratory ciliated cells	23.9 nTPM
Bronchus	24.5 nTPM
Lung	23.3 nTPM

Smooth muscle cells	56.7 nTPM
Bronchus	150.5 nTPM
Pancreas	108.5 nTPM
Prostate	73.8 nTPM
Skeletal muscle	47.9 nTPM
Endometrium	46.8 nTPM
Breast	41.0 nTPM
Adipose tissue	40.5 nTPM
Skin	39.4 nTPM
Ovary	37.4 nTPM
Esophagus	27.9 nTPM
Heart muscle	10.0 nTPM

T-cells	81.5 nTPM
Ovary	126.8 nTPM
Prostate	113.7 nTPM
Adipose tissue	113.1 nTPM
Liver	112.4 nTPM
Endometrium	105.4 nTPM
Breast	103.0 nTPM
Colon	98.3 nTPM
Skeletal muscle	96.0 nTPM
Bone marrow	82.8 nTPM
Esophagus	78.6 nTPM
Kidney	71.2 nTPM
Stomach	69.5 nTPM
Spleen	64.4 nTPM
Skin	52.0 nTPM
PBMC	48.2 nTPM
Lymph node	30.0 nTPM
Lung	19.7 nTPM

Basal keratinocytes	38.7 nTPM
Skin	38.7 nTPM

Basal prostatic cells	64.8 nTPM
Prostate	64.8 nTPM

Basal respiratory cells	26.6 nTPM
Bronchus	26.6 nTPM

Basal squamous epithelial cells	30.1 nTPM
Esophagus	30.1 nTPM

Undifferentiated cells	55.8 nTPM
Colon	57.2 nTPM
Small intestine	56.0 nTPM
Rectum	54.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC