Single cell type - STX17 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STX17
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin 17
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STX17 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 1
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
POLI	DNA polymerase iota	0.5602	66
CCDC178	Coiled-coil domain containing 178	0.5216	66
ZNF429	Zinc finger protein 429	0.5151	52
ZNF239	Zinc finger protein 239	0.5086	23
C8orf89	Chromosome 8 open reading frame 89	0.4930	23
ZBED9	Zinc finger BED-type containing 9	0.4921	66
C3orf38	Chromosome 3 open reading frame 38	0.4912	23
C10orf88	Chromosome 10 open reading frame 88	0.4876	23
CYP2R1	Cytochrome P450 family 2 subfamily R member 1	0.4769	23
AGBL3	ATP/GTP binding protein like 3	0.4745	23
MEI4	Meiotic double-stranded break formation protein 4	0.4740	23
CAMK4	Calcium/calmodulin dependent protein kinase IV	0.4717	58
ANKAR	Ankyrin and armadillo repeat containing	0.4704	23
LIPJ	Lipase family member J	0.4699	23
TRMT1L	TRNA methyltransferase 1 like	0.4696	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.1 nTPM
Breast	28.8 nTPM
Adipose tissue	21.5 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	32.6 nTPM
Lung	32.6 nTPM

Astrocytes	35.6 nTPM
Brain	35.6 nTPM

B-cells	26.2 nTPM
Bone marrow	36.0 nTPM
Stomach	34.9 nTPM
Spleen	33.9 nTPM
Lymph node	30.3 nTPM
Colon	25.5 nTPM
Adipose tissue	25.1 nTPM
Kidney	23.8 nTPM
Breast	20.0 nTPM
PBMC	17.1 nTPM
Liver	15.6 nTPM

Dendritic cells	21.5 nTPM
Breast	25.9 nTPM
Adipose tissue	22.6 nTPM
PBMC	16.0 nTPM

Endothelial cells	18.7 nTPM
Lung	31.2 nTPM
Testis	27.2 nTPM
Skeletal muscle	27.1 nTPM
Eye	21.8 nTPM
Esophagus	20.7 nTPM
Breast	20.0 nTPM
Endometrium	19.8 nTPM
Heart muscle	16.9 nTPM
Liver	16.5 nTPM
Prostate	15.8 nTPM
Ovary	15.2 nTPM
Skin	12.5 nTPM
Placenta	9.1 nTPM
Pancreas	7.7 nTPM

Fibroblasts	18.0 nTPM
Esophagus	31.4 nTPM
Breast	25.1 nTPM
Adipose tissue	23.0 nTPM
Skeletal muscle	22.7 nTPM
Prostate	22.2 nTPM
Ovary	17.3 nTPM
Stomach	14.9 nTPM
Placenta	14.1 nTPM
Skin	11.4 nTPM
Heart muscle	11.1 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	15.7 nTPM
Rectum	18.0 nTPM
Small intestine	15.6 nTPM
Colon	13.6 nTPM

Macrophages	17.1 nTPM
Breast	31.0 nTPM
Spleen	22.8 nTPM
Bone marrow	22.5 nTPM
Prostate	21.8 nTPM
Ovary	19.9 nTPM
Testis	19.7 nTPM
Esophagus	18.9 nTPM
Lung	16.9 nTPM
Endometrium	15.7 nTPM
Adipose tissue	15.3 nTPM
Kidney	15.2 nTPM
Skeletal muscle	14.8 nTPM
PBMC	13.6 nTPM
Stomach	5.9 nTPM
Pancreas	2.5 nTPM

Paneth cells	18.1 nTPM
Small intestine	30.0 nTPM
Rectum	17.7 nTPM
Colon	6.5 nTPM

Plasma cells	24.4 nTPM
Esophagus	30.7 nTPM
Spleen	29.0 nTPM
Stomach	28.3 nTPM
Bone marrow	19.8 nTPM
Adipose tissue	14.2 nTPM

Respiratory ciliated cells	19.6 nTPM
Lung	26.2 nTPM
Bronchus	12.9 nTPM

Smooth muscle cells	20.2 nTPM
Esophagus	44.9 nTPM
Heart muscle	27.8 nTPM
Adipose tissue	24.5 nTPM
Breast	24.2 nTPM
Skeletal muscle	21.6 nTPM
Ovary	19.7 nTPM
Endometrium	16.0 nTPM
Prostate	15.7 nTPM
Skin	12.9 nTPM
Pancreas	9.8 nTPM
Bronchus	4.6 nTPM

T-cells	26.6 nTPM
Spleen	45.5 nTPM
Bone marrow	42.8 nTPM
Lymph node	40.2 nTPM
PBMC	38.4 nTPM
Prostate	33.1 nTPM
Stomach	33.0 nTPM
Breast	28.3 nTPM
Lung	27.4 nTPM
Adipose tissue	27.2 nTPM
Skeletal muscle	22.6 nTPM
Endometrium	20.8 nTPM
Liver	20.5 nTPM
Kidney	17.8 nTPM
Colon	14.2 nTPM
Skin	13.8 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	10.6 nTPM
Skin	10.6 nTPM

Basal prostatic cells	19.2 nTPM
Prostate	19.2 nTPM

Basal respiratory cells	13.9 nTPM
Bronchus	13.9 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Undifferentiated cells	16.2 nTPM
Small intestine	19.9 nTPM
Rectum	15.3 nTPM
Colon	13.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC