Single cell type - ARPC5L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARPC5L
Gene descriptionⁱ Full gene name according to HGNC.	Actin related protein 2/3 complex subunit 5 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ARPC5L is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM71E1	Family with sequence similarity 71 member E1	0.6701	34
C10orf82	Chromosome 10 open reading frame 82	0.6691	34
TXNDC8	Thioredoxin domain containing 8	0.6684	34
TNP1	Transition protein 1	0.6672	34
MSMP	Microseminoprotein, prostate associated	0.6663	34
EEF2KMT	Eukaryotic elongation factor 2 lysine methyltransferase	0.6602	34
FBL	Fibrillarin	0.6574	34
HMGB4	High mobility group box 4	0.6566	34
IGHV3OR16-10	Immunoglobulin heavy variable 3/OR16-10 (non-functional)	0.6555	34
C8orf74	Chromosome 8 open reading frame 74	0.6522	34
PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha	0.6520	34
GNG2	G protein subunit gamma 2	0.6486	34
MS4A5	Membrane spanning 4-domains A5	0.6468	34
SLAMF6	SLAM family member 6	0.6460	63
SPATA24	Spermatogenesis associated 24	0.6459	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	79.4 nTPM
Adipose tissue	79.4 nTPM
Breast	79.4 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	64.4 nTPM
Lung	64.4 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	98.7 nTPM
Liver	201.6 nTPM
Kidney	104.8 nTPM
Spleen	104.5 nTPM
Bone marrow	99.7 nTPM
Colon	99.0 nTPM
Lymph node	97.0 nTPM
Breast	81.7 nTPM
Adipose tissue	72.7 nTPM
Stomach	64.9 nTPM
PBMC	61.4 nTPM

Basal squamous epithelial cells	101.3 nTPM
Esophagus	101.3 nTPM

Dendritic cells	143.9 nTPM
Breast	230.7 nTPM
Adipose tissue	137.1 nTPM
PBMC	63.8 nTPM

Endothelial cells	119.5 nTPM
Prostate	345.4 nTPM
Pancreas	216.2 nTPM
Skin	202.8 nTPM
Esophagus	130.1 nTPM
Placenta	129.0 nTPM
Ovary	117.0 nTPM
Endometrium	99.8 nTPM
Lung	74.8 nTPM
Breast	72.1 nTPM
Testis	69.6 nTPM
Skeletal muscle	67.7 nTPM
Liver	57.7 nTPM
Eye	54.2 nTPM
Heart muscle	36.0 nTPM

Fibroblasts	49.0 nTPM
Skin	80.0 nTPM
Prostate	72.7 nTPM
Ovary	71.3 nTPM
Placenta	63.9 nTPM
Lung	53.6 nTPM
Breast	43.9 nTPM
Stomach	41.6 nTPM
Skeletal muscle	32.3 nTPM
Heart muscle	32.1 nTPM
Esophagus	24.2 nTPM
Adipose tissue	23.6 nTPM

Intestinal goblet cells	83.8 nTPM
Colon	131.5 nTPM
Small intestine	61.3 nTPM
Rectum	58.5 nTPM

Macrophages	48.9 nTPM
Stomach	64.5 nTPM
Kidney	62.8 nTPM
Pancreas	58.7 nTPM
Breast	58.6 nTPM
Esophagus	58.3 nTPM
Prostate	57.3 nTPM
Bone marrow	56.3 nTPM
Ovary	54.4 nTPM
Endometrium	50.5 nTPM
Testis	46.4 nTPM
Skeletal muscle	40.3 nTPM
Lung	39.0 nTPM
Adipose tissue	32.9 nTPM
PBMC	27.3 nTPM
Spleen	26.0 nTPM

Paneth cells	92.5 nTPM
Colon	148.2 nTPM
Rectum	65.4 nTPM
Small intestine	63.8 nTPM

Plasma cells	150.8 nTPM
Spleen	241.6 nTPM
Bone marrow	174.7 nTPM
Esophagus	166.4 nTPM
Stomach	110.0 nTPM
Adipose tissue	61.3 nTPM

Respiratory ciliated cells	77.5 nTPM
Bronchus	98.1 nTPM
Lung	56.9 nTPM

Smooth muscle cells	71.1 nTPM
Bronchus	170.8 nTPM
Pancreas	157.6 nTPM
Ovary	99.1 nTPM
Skin	72.5 nTPM
Prostate	57.9 nTPM
Breast	49.4 nTPM
Esophagus	40.3 nTPM
Endometrium	39.3 nTPM
Skeletal muscle	36.9 nTPM
Heart muscle	29.7 nTPM
Adipose tissue	28.4 nTPM

Cholangiocytes	71.4 nTPM
Liver	71.4 nTPM

Collecting duct cells	68.0 nTPM
Kidney	68.0 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	152.2 nTPM
Placenta	152.2 nTPM

T-cells	137.2 nTPM
Liver	256.5 nTPM
Ovary	246.9 nTPM
Skin	191.1 nTPM
Bone marrow	190.5 nTPM
Kidney	186.9 nTPM
Esophagus	163.7 nTPM
Endometrium	123.4 nTPM
Spleen	116.6 nTPM
Skeletal muscle	111.2 nTPM
Breast	110.3 nTPM
Lymph node	106.6 nTPM
PBMC	98.4 nTPM
Adipose tissue	93.2 nTPM
Lung	91.1 nTPM
Prostate	85.2 nTPM
Colon	82.7 nTPM
Stomach	77.6 nTPM

Undifferentiated cells	99.9 nTPM
Colon	147.5 nTPM
Rectum	80.0 nTPM
Small intestine	72.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC