Single cell type - CTDSPL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTDSPL2
Gene descriptionⁱ Full gene name according to HGNC.	CTD small phosphatase like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CTDSPL2 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CEP350	Centrosomal protein 350	0.7827	34
BAG5	BAG cochaperone 5	0.7431	34
GRXCR2	Glutaredoxin and cysteine rich domain containing 2	0.7422	34
HSFY1	Heat shock transcription factor Y-linked 1	0.7368	34
WDR64	WD repeat domain 64	0.7310	34
AKR1E2	Aldo-keto reductase family 1 member E2	0.7117	34
MSANTD1	Myb/SANT DNA binding domain containing 1	0.7105	34
CEP112	Centrosomal protein 112	0.7079	34
NT5C1B-RDH14	NT5C1B-RDH14 readthrough	0.7073	34
TTLL2	Tubulin tyrosine ligase like 2	0.7020	34
C1orf100	Chromosome 1 open reading frame 100	0.6971	34
TFAM	Transcription factor A, mitochondrial	0.6953	34
WDR20	WD repeat domain 20	0.6861	34
PCDHGB1	Protocadherin gamma subfamily B, 1	0.6848	34
TRIM42	Tripartite motif containing 42	0.6780	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.4 nTPM
Adipose tissue	35.7 nTPM
Breast	33.0 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	35.7 nTPM
Lung	35.7 nTPM

Astrocytes	26.4 nTPM
Brain	26.4 nTPM

B-cells	25.4 nTPM
Adipose tissue	46.1 nTPM
Lymph node	35.1 nTPM
Spleen	27.6 nTPM
Colon	25.5 nTPM
Stomach	25.5 nTPM
Kidney	23.8 nTPM
Breast	20.0 nTPM
PBMC	18.6 nTPM
Bone marrow	16.4 nTPM
Liver	15.1 nTPM

Dendritic cells	40.9 nTPM
Adipose tissue	60.8 nTPM
Breast	33.9 nTPM
PBMC	27.9 nTPM

Endothelial cells	27.2 nTPM
Heart muscle	67.4 nTPM
Endometrium	35.8 nTPM
Skeletal muscle	33.5 nTPM
Breast	29.9 nTPM
Esophagus	29.5 nTPM
Ovary	26.2 nTPM
Lung	24.9 nTPM
Skin	24.2 nTPM
Liver	22.0 nTPM
Testis	19.3 nTPM
Eye	18.6 nTPM
Prostate	17.3 nTPM
Placenta	16.5 nTPM
Pancreas	15.5 nTPM

Fibroblasts	30.2 nTPM
Heart muscle	82.6 nTPM
Breast	33.8 nTPM
Adipose tissue	32.8 nTPM
Ovary	27.7 nTPM
Skeletal muscle	27.6 nTPM
Lung	26.8 nTPM
Skin	24.7 nTPM
Esophagus	23.4 nTPM
Stomach	22.3 nTPM
Prostate	16.5 nTPM
Placenta	13.8 nTPM

Intestinal goblet cells	13.9 nTPM
Rectum	15.5 nTPM
Small intestine	13.4 nTPM
Colon	12.9 nTPM

Macrophages	22.1 nTPM
Lung	36.8 nTPM
Adipose tissue	31.9 nTPM
Esophagus	29.9 nTPM
Endometrium	28.7 nTPM
Spleen	27.9 nTPM
Breast	25.5 nTPM
Skeletal muscle	24.6 nTPM
Stomach	23.5 nTPM
Bone marrow	22.5 nTPM
Ovary	22.2 nTPM
Testis	18.6 nTPM
Prostate	16.0 nTPM
Kidney	15.8 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	10.4 nTPM
Rectum	13.7 nTPM
Colon	9.9 nTPM
Small intestine	7.5 nTPM

Plasma cells	24.0 nTPM
Adipose tissue	43.2 nTPM
Esophagus	24.6 nTPM
Spleen	24.0 nTPM
Stomach	15.1 nTPM
Bone marrow	13.2 nTPM

Respiratory ciliated cells	19.5 nTPM
Lung	24.8 nTPM
Bronchus	14.1 nTPM

Smooth muscle cells	34.2 nTPM
Heart muscle	96.5 nTPM
Bronchus	56.7 nTPM
Endometrium	42.2 nTPM
Adipose tissue	35.8 nTPM
Skeletal muscle	29.9 nTPM
Breast	25.1 nTPM
Ovary	23.5 nTPM
Esophagus	20.1 nTPM
Skin	18.8 nTPM
Prostate	14.7 nTPM
Pancreas	12.9 nTPM

T-cells	31.4 nTPM
Adipose tissue	65.1 nTPM
Lung	51.6 nTPM
Endometrium	43.5 nTPM
Breast	36.7 nTPM
Skeletal muscle	35.8 nTPM
Lymph node	34.6 nTPM
Esophagus	32.8 nTPM
PBMC	29.7 nTPM
Colon	28.5 nTPM
Bone marrow	26.2 nTPM
Liver	25.8 nTPM
Spleen	24.4 nTPM
Stomach	23.1 nTPM
Ovary	22.3 nTPM
Skin	21.6 nTPM
Kidney	17.8 nTPM
Prostate	14.2 nTPM

Basal respiratory cells	14.5 nTPM
Bronchus	14.5 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Cytotrophoblasts	18.9 nTPM
Placenta	18.9 nTPM

Distal enterocytes	16.9 nTPM
Colon	17.2 nTPM
Rectum	16.8 nTPM

Undifferentiated cells	15.3 nTPM
Small intestine	16.6 nTPM
Rectum	14.8 nTPM
Colon	14.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC