Single cell type - CNOT6L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CNOT6L
Gene descriptionⁱ Full gene name according to HGNC.	CCR4-NOT transcription complex subunit 6 like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (dendritic cells, T-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (dendritic cells, T-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CNOT6L is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
H2AC15	H2A clustered histone 15	0.9484	24
TAFA1	TAFA chemokine like family member 1	0.9303	24
PLAAT2	Phospholipase A and acyltransferase 2	0.9194	24
H2AC17	H2A clustered histone 17	0.8924	24
RNF125	Ring finger protein 125	0.8900	24
RESF1	Retroelement silencing factor 1	0.8826	24
ZNF831	Zinc finger protein 831	0.8815	24
H3C11	H3 clustered histone 11	0.8739	24
PLAAT4	Phospholipase A and acyltransferase 4	0.8731	24
H1-3	H1.3 linker histone, cluster member	0.8669	24
CEMIP2	Cell migration inducing hyaluronidase 2	0.8652	24
H4C15	H4 clustered histone 15	0.8652	24
ETS1	ETS proto-oncogene 1, transcription factor	0.8650	24
SLA	Src like adaptor	0.8643	24
TARS3	Threonyl-tRNA synthetase 3	0.8630	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	93.0 nTPM
Adipose tissue	125.9 nTPM
Breast	60.1 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	21.0 nTPM
Lung	21.0 nTPM

Astrocytes	34.3 nTPM
Brain	34.3 nTPM

B-cells	101.1 nTPM
Adipose tissue	306.2 nTPM
Colon	143.8 nTPM
Lymph node	103.2 nTPM
Stomach	99.5 nTPM
Spleen	90.7 nTPM
Bone marrow	71.9 nTPM
PBMC	64.2 nTPM
Breast	61.5 nTPM
Liver	37.1 nTPM
Kidney	33.4 nTPM

Dendritic cells	366.6 nTPM
Adipose tissue	862.5 nTPM
Breast	173.5 nTPM
PBMC	63.8 nTPM

Endothelial cells	54.0 nTPM
Skin	99.5 nTPM
Esophagus	78.9 nTPM
Skeletal muscle	78.7 nTPM
Prostate	63.7 nTPM
Ovary	54.9 nTPM
Testis	53.6 nTPM
Breast	52.4 nTPM
Eye	51.8 nTPM
Heart muscle	49.4 nTPM
Endometrium	49.0 nTPM
Liver	46.7 nTPM
Placenta	29.6 nTPM
Lung	28.1 nTPM
Pancreas	19.3 nTPM

Fibroblasts	25.1 nTPM
Heart muscle	44.6 nTPM
Skin	32.8 nTPM
Stomach	28.2 nTPM
Esophagus	26.8 nTPM
Skeletal muscle	24.8 nTPM
Prostate	23.7 nTPM
Breast	23.1 nTPM
Adipose tissue	22.4 nTPM
Ovary	19.6 nTPM
Lung	15.7 nTPM
Placenta	14.2 nTPM

Intestinal goblet cells	29.8 nTPM
Small intestine	39.6 nTPM
Rectum	32.1 nTPM
Colon	17.9 nTPM

Macrophages	50.0 nTPM
Adipose tissue	137.0 nTPM
Spleen	79.9 nTPM
Esophagus	59.8 nTPM
Breast	59.6 nTPM
Bone marrow	53.7 nTPM
Stomach	52.7 nTPM
Prostate	49.2 nTPM
Skeletal muscle	48.5 nTPM
Kidney	42.4 nTPM
Ovary	34.8 nTPM
Testis	31.4 nTPM
Endometrium	29.4 nTPM
PBMC	27.3 nTPM
Lung	26.2 nTPM
Pancreas	17.8 nTPM

Paneth cells	16.1 nTPM
Rectum	26.9 nTPM
Small intestine	15.0 nTPM
Colon	6.5 nTPM

Plasma cells	178.5 nTPM
Adipose tissue	706.3 nTPM
Stomach	55.9 nTPM
Esophagus	49.4 nTPM
Spleen	49.4 nTPM
Bone marrow	31.3 nTPM

Respiratory ciliated cells	17.0 nTPM
Bronchus	17.9 nTPM
Lung	16.0 nTPM

Smooth muscle cells	29.2 nTPM
Skin	40.8 nTPM
Esophagus	38.8 nTPM
Heart muscle	34.9 nTPM
Skeletal muscle	33.5 nTPM
Bronchus	33.1 nTPM
Adipose tissue	32.4 nTPM
Breast	31.6 nTPM
Prostate	27.2 nTPM
Endometrium	25.5 nTPM
Ovary	18.6 nTPM
Pancreas	4.3 nTPM

T-cells	240.0 nTPM
Adipose tissue	1164.7 nTPM
Skin	347.2 nTPM
Colon	345.4 nTPM
Skeletal muscle	300.7 nTPM
Stomach	225.9 nTPM
Breast	224.3 nTPM
Spleen	220.1 nTPM
Lymph node	206.9 nTPM
Endometrium	196.9 nTPM
Prostate	165.6 nTPM
Liver	118.2 nTPM
Ovary	115.7 nTPM
Esophagus	111.4 nTPM
Bone marrow	100.6 nTPM
PBMC	93.9 nTPM
Kidney	82.2 nTPM
Lung	60.7 nTPM

Basal keratinocytes	57.9 nTPM
Skin	57.9 nTPM

Basal prostatic cells	13.3 nTPM
Prostate	13.3 nTPM

Basal respiratory cells	15.9 nTPM
Bronchus	15.9 nTPM

Basal squamous epithelial cells	59.2 nTPM
Esophagus	59.2 nTPM

Undifferentiated cells	24.1 nTPM
Small intestine	28.0 nTPM
Rectum	25.9 nTPM
Colon	18.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC