Single cell type - NDUFA9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA9
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFA9 is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPS25	Mitochondrial ribosomal protein S25	0.7637	31
MORN3	MORN repeat containing 3	0.7605	25
DNAJB8	DnaJ heat shock protein family (Hsp40) member B8	0.7574	25
BCL2L14	BCL2 like 14	0.7485	25
UBQLNL	Ubiquilin like	0.7436	25
HDAC11	Histone deacetylase 11	0.7407	25
UBQLN3	Ubiquilin 3	0.7372	25
PROCA1	Protein interacting with cyclin A1	0.7285	25
UBL4B	Ubiquitin like 4B	0.7270	25
HYAL3	Hyaluronidase 3	0.7252	31
CCDC91	Coiled-coil domain containing 91	0.7235	25
SMCP	Sperm mitochondria associated cysteine rich protein	0.7179	25
LELP1	Late cornified envelope like proline rich 1	0.7177	25
TSPAN16	Tetraspanin 16	0.7149	25
STX8	Syntaxin 8	0.7120	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	37.5 nTPM
Breast	43.9 nTPM
Adipose tissue	31.2 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	32.1 nTPM
Lung	32.1 nTPM

Astrocytes	26.1 nTPM
Brain	26.1 nTPM

B-cells	45.2 nTPM
Liver	103.7 nTPM
Kidney	61.9 nTPM
Stomach	45.9 nTPM
PBMC	44.2 nTPM
Spleen	40.1 nTPM
Colon	36.7 nTPM
Lymph node	36.3 nTPM
Bone marrow	35.1 nTPM
Adipose tissue	27.6 nTPM
Breast	20.0 nTPM

Dendritic cells	45.7 nTPM
PBMC	47.8 nTPM
Breast	47.4 nTPM
Adipose tissue	42.0 nTPM

Endothelial cells	46.4 nTPM
Pancreas	108.1 nTPM
Placenta	75.1 nTPM
Heart muscle	57.6 nTPM
Eye	49.3 nTPM
Ovary	47.6 nTPM
Testis	42.9 nTPM
Lung	40.6 nTPM
Breast	37.7 nTPM
Liver	37.6 nTPM
Skeletal muscle	36.2 nTPM
Skin	35.4 nTPM
Prostate	34.1 nTPM
Endometrium	27.5 nTPM
Esophagus	20.1 nTPM

Fibroblasts	38.5 nTPM
Placenta	56.1 nTPM
Ovary	51.9 nTPM
Heart muscle	51.0 nTPM
Adipose tissue	39.4 nTPM
Breast	38.8 nTPM
Skin	35.8 nTPM
Skeletal muscle	33.9 nTPM
Lung	32.4 nTPM
Esophagus	30.6 nTPM
Stomach	26.7 nTPM
Prostate	26.6 nTPM

Intestinal goblet cells	125.4 nTPM
Colon	182.9 nTPM
Rectum	117.7 nTPM
Small intestine	75.4 nTPM

Macrophages	41.8 nTPM
Pancreas	107.2 nTPM
Kidney	80.1 nTPM
Lung	60.8 nTPM
Testis	47.7 nTPM
Prostate	42.3 nTPM
Ovary	41.1 nTPM
Breast	38.2 nTPM
Bone marrow	35.0 nTPM
Endometrium	34.8 nTPM
Stomach	32.2 nTPM
Adipose tissue	32.1 nTPM
Skeletal muscle	28.7 nTPM
Spleen	27.0 nTPM
Esophagus	20.4 nTPM
PBMC	0.0 nTPM

Paneth cells	83.5 nTPM
Small intestine	112.7 nTPM
Rectum	104.8 nTPM
Colon	32.9 nTPM

Plasma cells	50.8 nTPM
Spleen	79.6 nTPM
Bone marrow	59.4 nTPM
Stomach	54.7 nTPM
Esophagus	36.9 nTPM
Adipose tissue	23.3 nTPM

Respiratory ciliated cells	74.9 nTPM
Bronchus	104.7 nTPM
Lung	45.2 nTPM

Smooth muscle cells	54.8 nTPM
Pancreas	132.9 nTPM
Bronchus	69.7 nTPM
Heart muscle	63.4 nTPM
Ovary	60.2 nTPM
Breast	48.6 nTPM
Prostate	47.8 nTPM
Skeletal muscle	43.6 nTPM
Skin	37.0 nTPM
Adipose tissue	36.9 nTPM
Esophagus	35.7 nTPM
Endometrium	26.8 nTPM

T-cells	43.4 nTPM
Kidney	76.0 nTPM
Ovary	57.8 nTPM
Liver	53.5 nTPM
Lung	53.2 nTPM
Stomach	51.6 nTPM
Skin	51.1 nTPM
Bone marrow	48.9 nTPM
Colon	46.6 nTPM
Spleen	46.0 nTPM
Prostate	42.6 nTPM
Adipose tissue	39.0 nTPM
PBMC	37.1 nTPM
Breast	36.6 nTPM
Lymph node	33.8 nTPM
Skeletal muscle	28.8 nTPM
Endometrium	28.5 nTPM
Esophagus	6.6 nTPM

Basal prostatic cells	63.7 nTPM
Prostate	63.7 nTPM

Basal respiratory cells	199.3 nTPM
Bronchus	199.3 nTPM

Basal squamous epithelial cells	21.6 nTPM
Esophagus	21.6 nTPM

Cholangiocytes	45.8 nTPM
Liver	45.8 nTPM

Undifferentiated cells	147.7 nTPM
Colon	199.0 nTPM
Rectum	125.0 nTPM
Small intestine	119.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC