Single cell type - ACVRL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACVRL1
Gene descriptionⁱ Full gene name according to HGNC.	Activin A receptor like type 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Adipocytes, Endothelial cells, Paneth cells, Hepatic stellate cells, Fibroblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Adipocytes, Endothelial cells, Paneth cells, Hepatic stellate cells, Fibroblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACVRL1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MUC12	Mucin 12, cell surface associated	0.6802	53
C10orf99	Chromosome 10 open reading frame 99	0.6754	53
PDE4C	Phosphodiesterase 4C	0.6675	53
MMP15	Matrix metallopeptidase 15	0.6533	53
ST6GALNAC6	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	0.6449	53
GGT6	Gamma-glutamyltransferase 6	0.6423	53
ETHE1	ETHE1 persulfide dioxygenase	0.6323	53
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.6232	53
PLCD3	Phospholipase C delta 3	0.6231	53
HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2	0.6206	53
HRCT1	Histidine rich carboxyl terminus 1	0.6187	53
GPA33	Glycoprotein A33	0.6173	53
DENND2A	DENN domain containing 2A	0.6150	53
CASP7	Caspase 7	0.6148	53
SHD	Src homology 2 domain containing transforming protein D	0.6108	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	7.9 nTPM
Lung	7.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.6 nTPM
Colon	3.2 nTPM
Breast	1.3 nTPM
Liver	0.9 nTPM
Stomach	0.5 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	5.2 nTPM
Skin	5.2 nTPM

Dendritic cells	0.3 nTPM
Breast	0.7 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	84.7 nTPM
Placenta	152.9 nTPM
Pancreas	150.6 nTPM
Eye	116.5 nTPM
Ovary	104.5 nTPM
Skeletal muscle	102.9 nTPM
Lung	87.4 nTPM
Endometrium	86.2 nTPM
Breast	74.9 nTPM
Esophagus	74.2 nTPM
Heart muscle	65.3 nTPM
Prostate	60.2 nTPM
Liver	43.1 nTPM
Skin	37.9 nTPM
Testis	29.3 nTPM

Fibroblasts	56.0 nTPM
Skeletal muscle	135.9 nTPM
Adipose tissue	111.6 nTPM
Breast	75.3 nTPM
Esophagus	72.0 nTPM
Skin	71.7 nTPM
Stomach	68.3 nTPM
Prostate	26.1 nTPM
Heart muscle	18.9 nTPM
Placenta	18.8 nTPM
Lung	15.7 nTPM
Ovary	1.2 nTPM

Intestinal goblet cells	26.4 nTPM
Rectum	48.1 nTPM
Colon	24.3 nTPM
Small intestine	6.9 nTPM

Macrophages	7.8 nTPM
Pancreas	23.0 nTPM
Lung	18.6 nTPM
Endometrium	11.9 nTPM
Skeletal muscle	11.9 nTPM
Bone marrow	10.0 nTPM
Esophagus	7.9 nTPM
Spleen	7.2 nTPM
Prostate	5.7 nTPM
Adipose tissue	5.2 nTPM
Kidney	4.6 nTPM
Testis	3.5 nTPM
Breast	3.2 nTPM
Stomach	2.9 nTPM
Ovary	1.5 nTPM
PBMC	0.0 nTPM

Paneth cells	74.7 nTPM
Colon	168.0 nTPM
Rectum	56.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	0.1 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	2.8 nTPM
Lung	4.4 nTPM
Bronchus	1.3 nTPM

Smooth muscle cells	18.2 nTPM
Adipose tissue	70.7 nTPM
Skeletal muscle	28.7 nTPM
Prostate	22.6 nTPM
Breast	17.6 nTPM
Heart muscle	16.9 nTPM
Skin	15.3 nTPM
Ovary	9.4 nTPM
Pancreas	7.9 nTPM
Endometrium	6.6 nTPM
Esophagus	4.6 nTPM
Bronchus	0.0 nTPM

T-cells	1.2 nTPM
Skin	9.7 nTPM
Colon	2.9 nTPM
Skeletal muscle	2.5 nTPM
Endometrium	2.1 nTPM
Breast	1.9 nTPM
Liver	0.7 nTPM
Adipose tissue	0.1 nTPM
Bone marrow	0.1 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM

Distal enterocytes	182.7 nTPM
Rectum	220.7 nTPM
Colon	144.8 nTPM

Endometrial stromal cells	19.9 nTPM
Endometrium	19.9 nTPM

Exocrine glandular cells	1.4 nTPM
Pancreas	1.4 nTPM

Undifferentiated cells	49.3 nTPM
Colon	71.8 nTPM
Rectum	68.9 nTPM
Small intestine	7.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC